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Title: "The role of insulin resistance in the treatment of
non-insulin-dependent diabetes mellitus"
Title: "Decreased free insulin levels during euglycemic
hyperinsulinemic clamp in non-insulin-dependent diabetics on insulin
therapy"
Title: "Improvement of lipoprotein lipid composition in type II
diabetic patients with concomitant hyperlipoproteinemia by acipimox
treatment"
Title: "The effect of Acipimox (lipid lowering agent) in
non-insulin-dependent diabetics treated with glipizide"
Title: "Insulin sensitivity and HDL cholesterol levels in
hyperlipemic non-diabetics and non-insulin dependent diabetics"
Title: "The regulation of hypertriglyceridemia improves
peripheral insulin sensitivity"
Title: "Serum paraoxonase and cholinesterase activities in
individuals with lipid and glucose metabolism disorders"
Title: "A review of specific indications in view of the
administration of hypolipemics"
Title: "Apoproteins A1, B and (a) in patients with
hyperlipoproteinemia type II and IV with or without diabetes"
Title: "Main lipoproteins and apoproteins A1 and B in
hyperlipemic patients without and with non-insulin-dependent diabetes
mellitus"
Title: "Increased insulin resistance in moderately hypertensive
and normotensive hyperlipemic subjects as a risk factor of coronary heart
failure"
Title: "High-density lipoproteins and apoproteins A1 and B in
obese hyperlipoproteinemics with and without non-insulin-dependent diabetes
mellitus"
Title: The influence of phenofibrate treatment upon lipoproteins
HDL2 and HDL3 subfractions and A I, A II and B apoproteins in various tzpes
of hyperlipoproteinemia
Title: Improvement of Lipoprotein Lipid Composition in
Hyperlipidemic Type II Diabetes by Acipimox (Olbetam) Treatment - Results
of a Multicenter Trial
Title: Serum paraoxanase and cholinesterase activities in
individuals with lipid and/or glucose metabiolism disorders.
Title: The improvement of peripheral insulin resistance after
pituttarz adenomas removal in acromegalic patients with normal glucose
tolerance
Title: Main lipoproteins and apoproteins A1, B and (a) in
hyperlipemic non-diebetics, newly discovered and chronic
non-insulin-dependent diabetics
Title:
Title: Insulinoms
Title:
Title:
Title: "Euglycemic hyperinsulinemic clamp in the peripheral
insulin resistance assessment in non-insulin-dependent diabetic patients"
Faculty: Medicinski Zagreb
Date of defense: 03/19/91
Language: hrvatski
Number of pages: 58
Summary: The pathophysiology of non-insulin-dependent diabetes
mellitus(NIDDM) involve abnormalities in at least three separate
organsystems. They are as follows: (1) increased basal hepatic
glucoseproduction, (2) various abnormalities in insulin secretion, and(3)
peripheral insulin resistance. The increased hepatic glucoseproduction rate
is primarily due to accelerated gluconeogenesisand is the major factor
leading to fasting hyperglycemia.Impairments in insulin
secretion,particularly in response toglucose stimuli, is differently
manifested in NIDDM patients,thereby confirming heterogeneous nature of the
disorder.Peripheral insulin resistance is a well-known
characteristicfeature in NIDDM, which is especially in combination
withimpaired insulin secretion, the main cause of
postprandialhyperglycemia. This research was aimed at: a) the evaluation
ofthe reliability of euglycemic hyperinsulinemic clamp technique asa method
for the assessment of insulin resistance, b) todetermine the degree of
peripheral insulin resistance as well asthe type of disturbance on the
cellular level in severaldifferently treated groups of NIDDM patients
(diet, oralhypoglycemic agents, insulin), c) to determine the state
ofresistance in the group of patients with secondary failure onoral
hypoglycemic agents therapy, and d) to evaluate the state oflipid
metabolism in NIDDM patients. The results of the studywhich included 56
NIDDM patients and 10 healthy subjects, revealthe following: 1) that the
euglycemic hyperinsulinemic clamp is areliable method for the peripheral
insulin resistance estimation,2) that the differing degrees of increased
insulin resistance arecharacteristic of NIDDM patients, 3) that mostly the
combinedreceptor-postreceptor defect is present and that its
intensityvaries from group to group of patients, depending on the state
ofdiabetes control, insulin secretion impairments and the type ofactual
therapy, as well as that, 4) dislipidemia is very frequentin NIDDM, and is
primarily manifested by hypertriglyceridemia,increased VDLD and decreased
HDL, which not only play animportant role in the development ofvthe
complications of thedisease, but can also intensify insulin resistance.
Keywords: Non-insulin-dependent diabetes mellitus (NIDDM), Peripheral insulin resistance, Diet, Oral hypoglycemic agents, Insulin therapy, Secondary failure of oral hypoglycemic agents, Hyperlipoproteinemia
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