- Type of paper
: Book
Title: Emergencies in cardioangiology
- Editors
- Polić, Stojan (77340)
- Polić, Stojan (77340)
- Lukin, Ajvor
Publisher: Znanstvena jedinica, KB Split
ISBN: 953-96411-1-x
Year: 1995
Number of pages: 380
Language: hrvatski
- Type of paper
: Paper in book
Title: Treatment of congestive heart failure
- Authors:
- Polić, Stojan (77340)
- Editors
- Mirić, Dinko
- Vuković, Ivo
Publisher: Krvatsko kardiološko društvo - ogranak Split
Year: 1994
Pages: from 191 to 202
Number of references: 13
Language: hrvatski
- Type of paper
: Paper in book
Title: Preexcitation syndrome
- Authors:
- Polić, Stojan (77340)
- Editors
- Polić, Stojan (77340)
- Lukin, Ajvor
Publisher: Znanstvena jedinica, KB Split
ISBN: 953-96411-1-x
Year: 1995
Pages: from 101 to 112
Number of references: 10
Language: hrvatski
- Type of paper
: Paper in book
Title: Cardiogenic pulmonary oedema
- Authors:
- Polić, Stojan (77340)
- Editors
- Polić, Stojan (77340)
- Lukin, Ajvor
Publisher: Znanstvena jedinica, KB Split
ISBN: 953-96411-1-x
Year: 1995
Pages: from 215 to 224
Number of references: 11
Language: hrvatski
- Type of paper
: Paper in book
Title: Dissection of aorta
- Authors:
- Polić, Stojan (77340)
- Editors
- Polić, Stojan (77340)
- Lukin, Ajvor
Publisher: Znanstvena jedinica, KB Split
ISBN: 953-96411-1-X
Year: 1995
Pages: from 355 to 366
Number of references: 17
Language: hrvatski
- Type of paper
: Paper in book
Title: Cardiotonic therapy - an up to date review
- Authors:
- Polić, Stojan (77340)
- Editors
- Rumboldt, Zvonko
Publisher: Znanstvena jedinica, KB Split
Year: 1992
Pages: from 172 to 179
Language: hrvatski
- Type of paper
: Paper in book
Title: Patient with atrial fibrillation - a therapeutic approach
- Authors:
- Polić, Stojan (77340)
- Editors
- Rumboldt, Zvonko
Publisher: Znanstvena jedinica, KB Split
Year: 1992
Pages: from 202 to 205
Language: hrvatski
- Type of paper
: Paper in book
Title: Therapeutic approach to preexcitation syndrome
- Authors:
- Polić, Stojan (77340)
- Editors
- Rumboldt, Zvonko
Publisher: Znanstvena jedinica, KB Split
Year: 1992
Pages: from 206 to 208
Language: hrvatski
- Type of paper
: Paper in journal
Title: ACTIONS ..
- Authors:
- Polić, Stojan (77340)
- Bošnjak, Željko
- Marijić, Jure
- Hoffmann, Raymond
- Kampine, John
- Turner, Lawrence
Journal: Anesthesia Analgesia
ISSN: 0033-2999
Volume: 73
Year: 1991
Pages: from 603 to 611
Number of references: 31
Language: engleski
Summary: The effects of halothane, isoflurane, and enflurane on
proximal(false tendon) and distal (apical) canine Purkinje fibers
weremeasured in vitro to assess their comparative effects on
fibersexhibiting characteristically long (proximal) and short
(distal)action potential duration. High- and low-dose anesthetic
effectswere evaluated in three groups of six left ventricularpreparations
and were compared with the changes occuring atidentical times in six
control preparations using analysis ofvariance with repeated measures. It
is concluded that theregional actions of anesthetics on Purkinje fiber
repolarizationmay influence conduction during the relative refractory
periodand the occurence of arrhythmias associated with disparity ofregional
refractory characteristics in the ventricular conductionsystem.
- Type of paper
: Paper in journal
Title: ANESTHETICS ...
- Authors:
- Polić, Stojan (77340)
- Atlee III, John
- Laszlo, Adam
- Kampine, John
- Bošnjak, Željko
Journal: Anesthesiology
ISSN: 0003-3022
Volume: 75
Year: 1991
Pages: from 298 to 304
Number of references: 43
Language: engleski
Summary: Knowledge of anesthetic effects on the automaticity of
dominantand subsidiary cardiac pacemakers is fundamental to anunderstanding
of mechanisms of arrhythmia during anesthesia, aswell as to the management
of patients with sinus node dysfunctionor atrioventricular (AV) conduction
block. How halothane,epinephrine (E), or norepinephrine (NE), alone or in
combination,would effect the relation between the automaticity of the SA
nodeand subsidiary atrialy pacemakers (SAP) was tested using anisolated
perfused canine right atrial preparation. It isconcluded that E or NA
augment the automaticity of SAP more thanthat of the SA node, with or
without halothane. Further, ectopicatrial rhythms with halothane require E
or augmented adrenergictone (NE).
Keywords: ANESTHETICS, ARRHYTHMIAS, SINUS NODE, ELECTROPHYSIOLOGY, EPINEPHRINE, NOREPINEPHRINE
- Type of paper
: Paper in journal
Title: ANESTHETICS ...
- Authors:
- Polić, Stojan (77340)
- Atlee III, John
- Laszlo, Adam
- Kampine, John
- Bošnjak, Željko
Journal: Anesthesiology
ISSN: 0033-3022
Volume: 75
Year: 1991
Pages: from 305 to 312
Number of references: 50
Language: engleski
Summary: Atrial tachyarrhythmias are a common manifestation of
digitalistoxicity. Such arrhythmias could be due to enhanced automaticityof
subsidiary atrial pacemakers (SAP) compared to the sinoatrial(SA) node.
Halothane is known to oppose digitalis-inducedventricular arrhythmias. Its
effect on digitalis-caused atrialarrhythmias is unknown. Therefore, we
tested two hypotheses, asfollows. First,increasing ouabain concentrations
would enhanceautomaticity of SAP compared to the SA node and that
suchenhanced automaticity could explain digitalis-inducedtachyarrhythmias.
Second, halothane would oppose such enhancedautomaticity of SAP, thereby
opposing digitalis-caused atrialtachyarrhythmias.Regardless of pacemaker
location, spontaneousheart rate tended to be increased by ouabainand slowed
byhalothane alone; this tendency was most pronounced for 1X10 (-7)M ouabain
or 2% halothane. In preparations with pacemaker shifts,spontaneous rate was
not different from control. Finally, totalatrial arrest was observed in six
preparations exposed to 1 or 2%halothane with 1X10 (-7) M ouabain. It is
concluded that in theperfused canine right atrial preparation, increasing
ouabain doesnot sufficiently enhance automaticity of SAP or SA node
toaccount for digitalis-caused atrial tachyarrhythmias. Further,borderline
toxic ouabain with halothane favors pacemakers shiftsfrom the SA node to
sites of SAP and in some preparations maycause atrial quiescence.
Keywords: ANESTHETICS, ARRHYTHMIAS, CARDIAC GLYCOZIDES, OUABAIN, ELECTROPHYSIOLOGY
- Type of paper
: Paper in journal
Title: ACTIONS ...
- Authors:
- Lawrence, A
- Turner, Lawrence
- Polić, Stojan (77340)
- Hoffmann, Raymond
- Kampine, John
- Bošnjak, Željko
Journal: Anesthesia Analgesia
ISSN: 0003-2999
Volume: 76
Year: 1993
Pages: from 718 to 725
Number of references: 27
Language: engleski
Summary: The actions of halothane (HAL) and isoflurane (ISO) on
conductionand regional refractoriness were studied in infarcted
caninehearts to compare their effects on reentry in vitro. In
twoanestheticgroups of 8 hearts, high and low dose effects wereassessed
using action potentials recorded from Purkinje fiberslocated in the
nonischemic regions. An extrastimulus techniquewas used to determine the
relationship between delay ofconduction of premature impulses into the more
refractoryischemic region and induction of reentrant responses. Theresults
indicate that the actions of both HAL and ISO onconduction and regional
refractoriness influence reentry and thatthe more prominent effects of HAL
on conduction of prematureimpulses into the infarct are more
"proarrhythmic" than those ofISO.
- Type of paper
: Paper in journal
Title: ELECTROCARDIOGRAPHIC PATTERN OF ACUTE MYOCARDIAL
INFARCTION IN PATIENT WITH FAR ADVANCED HYPERKALEMIA
- Authors:
- Polić, Stojan (77340)
- Rumboldt, Zvonko
- Bagatin, Jugoslav (61246)
Journal: Liječnički Vjesnik
ISSN: 0024-3477
Volume: 115
Year: 1993
Pages: from 40 to 42
Number of references: 14
Language: hrvatski
Summary: We report herein an insulin dependent diabetic with chronic
renalinsufficiency on hemodialysis who developed cardiogenic shock,severe
metabolic acidosis with kalemia of 9 mmol/l duringalimentary intoxication
and who presented with an ECG resemblingan acute myocardial infarction.
Possible pathophysiologic factorsin the development of such
electrocardiographic patterns havebeen outlined. It is concluded that in
far advanced hyperkalemiaan abnormal QRS complex, elevated ST segment and
no visible Pwaves should primarily suggest changes caused by
hyperkalemiarather than myocardial infarction.
Keywords: MYOCARDIAL INFARCTION, HYPERKALEMIA, ELECTROCARDIOGRAPHY
- Type of paper
: Paper in journal
Title: DIURETIC EFFICIENCY OF FUROSEMIDE IN CONTINUOUS
INTRAVENOUS INFUSION VS. BOLUS INJECTION IN CONGESTIVE HEART FAILURE:
RESULTS OF A PILOT STUDY
- Authors:
- Bagatin, Jugoslav (61246)
- Sardelić, Sanda
- Gančević, Ivana
- Rumboldt, Zvonko
- Polić, Stojan (77340)
- Bagatin, Jugoslav (61246)
- Pivac, Nediljko
Journal: Pharmaca
ISSN: 0031-6857
Volume: 31
Year: 1993
Pages: from 279 to 286
Number of references: 21
Language: hrvatski
Summary: In a randomized, single-blind clinical trial, diuretic
efficiencyof furosemide administered in either continuous
intravenousinfusion or conventional bolus injection was compared.
Includedwere 12 patients of both sexes (5 males and 7 females), aged 70.9
+/-6.9 years, with average body weight 75.0+/-15.1 kg, allsuffering from
congestive heart failure. The patients wererandomly assigned to two groups.
After a two-day period ofobservation each examinee received furosemide 40
mg b.i.d. eitheras an intravenous injection (Group A) or as an 1-hour
infusion(Group B), this shedule being reversed the next day. All
patientswere additionally treated with digoxin in an average dose of 0.25mg
o.d. Although the furosemide infusion resulted in greaterproportional
increase in urine output (in comparison withbaseline), there were no
significant differences between the twoways of furosemide administration,
regardless of the order ofapplication. It is concluded that in the
management of refractoryoedema in patients with congestive heart failure,
continuousintravenous infusion of furosemide is marginally more
effectivethan iv. bolus. Larger doses and longer infusion times
arepresumbly required for more pronounced diuresis.
Keywords: FUROSEMIDE, CONGESTIVE HEART FAILURE, INTRAVENOUS INJECTION, DIURESIS
- Type of paper
: Paper in journal
Title: Does amiloride decrease the incidence of digoxin
intoxication. 1st, prospective study.(in press)
- Authors:
- Polić, Stojan (77340)
- Naranča, Mario
- Rumboldt, Zvonko
- Lukin, Ajvor
- Bagatin, Jugoslav (61246)
Journal: Pharmaca
ISSN: 0031-6857
Year: 1995
Number of references: 28
Language: hrvatski
- Type of paper
: Paper in journal
Title:
- Authors:
- Polić, Stojan (77340)
- Naranča, Mario
- Rumboldt, Zvonko
- Lukin, Ajvor
- Dujić, Željko
- Bagatin, Jugoslav (61246)
Journal: Cardiologia Hungarica
Number: S3
ISSN: 0133-5596
Year: 1995
Pages: from 34 to 34
Language: engleski
- Type of paper
: Paper in journal
Title:
- Authors:
- Lukin, Ajvor
- Polić, Stojan (77340)
- Rumboldt, Zvonko
- Giunio, Lovel
Journal: Cardiologia Hungarica
Number: S3
ISSN: 0133-5596
Year: 1995
Pages: from 24 to 24
Language: engleski
Summary: Patients with dilated cardiomyopathy (DC) die in end stage
congestive heart failure because of severe arrhythmias and thromboembolism.
The purpose of the present study was to investigate the predictive factors
on mortality in patients with DC. Prospectivelly, between 11 and 40 months,
from November 1, 1991 to february 28, 1995, 1 and 2-D transthoracic
achocardiography (TTE), electrocardioraphy, laboratory data and clinical
status in 316 succesive, decompensated patients with idiopathic and
ischaemic DC were followed up. There were 246 males and 70 females, aged
59.o6 +/- 12.49 years. during the study period 24 patients died, 19 males
and 5 females. Compared were clinical findings, functional status and
cavitary dimensions obtained by TTE (i.e. LVEDd, RVEDd, LA) in the
surviving and the dead subgroup. The age of DC patients who died was
significantly higher (65.7 vs. 58.06 years; p = 0.005). Among
echocardiographic data there was no difference between right and left
diastolic ventricular diameter, but left atrial diameter in patients who
died from DC was larger (52.4 vs. 48.89; p=0.024). In the subgroup of
survivors with RVEDd below 30 mm, especially in those below 27 mm, a
substantial difference in life expectancy was found (p=0.014 and p<0.0001
respectively). Left ventricular EF obtained by TTE measurement was
significantly lower in deceased patients (24.25 vs. 33.88%, p<0.0001). A
significant difference in NYHA functional class was found as well (2.91 vs.
2.38, p<0.0001). Twelve patients who died during the study period had basal
sinus rhythm, and the same number had atrial fibrillation. We conclude that
severe left ventricular dysfunction accompanied with right ventricular
dilatations worsens life prognosis in patients with DC. Inour studyno
impact of basal rhythm on prognosis was found.
Keywords: dilated cardiomyopathy, thromboembolism
- Type of paper
: Paper in journal
Title:
- Authors:
- Giunio, Lovel
- Polić, Stojan (77340)
- Fabijanić, Damir
- Lukin, Ajvor
- Mirić, Dinko
- Božić, Ivo
- Kuzmanić, Ante (121695)
- Rakić, Drago (121684)
- Martinović, Duška
- Rumboldt, Zvonko
Journal: Cardiologia Hungarica
Number: S3
ISSN: 0133-5596
Year: 1995
Pages: from 11 to 11
Language: engleski
Summary: Purpose of this study was to compare intrevenous
propafenone (IVPR) to digoxin plus quinidine (DPQ) in conversion of
paroxysmal atrial fibrillation (PAF) of recent onset (<72 hours).
Methods: We randomly allocated 60 patients, aged 18 to 75 years, with PAF
to receive intravenous digoxin as acute scheme followed after 4h by
quinidine chlorhydrate (total dose 1500 mg/24 h) or intravenous propafenone
(2 mg/kg during 10 minutes). Patients were followed for 48 hours. Exclusion
criteria were heart failure (NYHA III), unstable coronary disease,
hypotension, AV block, WPW, curren treatment with antiarrhythmic agents or
digitalis. Left atrial diameter was similar in both groups.
Results: IVPR achieved significantly higher conversion rates at 1h, 3h, 6h
(67% vs 0%, 73% vs 17%, 83% vs 25%) compared with DPQ. The odds of
returning to sinus rhythm in the first 6 h were significantly greater for
IVPR treated patients (p<0.01). After 12h and 24h the difference between
IVPR and DPQ was not statistically significant (93% vs 75% and 93% vs 83%).
Conversion to sinus rhythm occured in 28 out of 30 patients allocated to
IVPR and in 26 out of 30 patients allocated to IVPR and in 26 out of 30
patients allocated to DPQ after 48 h. Mean conversion times were 112+/-198
for IVPR and 778+/-847 minutes for DPQ (p<0.01).
Conclusions: IVPR and DPQ are effective in restoring sinus rhythm in
patients with PAF of recent onset. The use of IVPR is associated with
quicker restoration of the sinus rhythm compared to DPQ.
Keywords: atrial finrillation, drug therapy, pharmacology
- Type of paper
: Paper in journal
Title: Some characteristics of patients treated for acute
myocardial infarction in Split within the period 1982-1992
- Authors:
- Mirić, Dinko
- Rumboldt, Zvonko
- Rumboldt, Mirjana
- Giunio, Lovel
- Polić, Stojan (77340)
- Pesenti, Serafina
- Caratan, Sandra
- Čulić, Viktor
Journal: Liječnički Vjesnik
Volume: 116
Year: 1994
Pages: from 79 to 82
Number of references: 27
Language: engleski
Summary: Three thousand three hundred and fifty-two patients (70%
males and 28% females) were hospitalized and treated in Split for acute
myocardial infarction (hospital mortality 20%) between 1982-1992. The
number of these admissions has been constantly rising from 226 in 1982 to
397 in 1992. Over 45 years of age were 3043 (90.8%) of the patients while
309 (9.2%= of them were under 45. The letality rate was 21% in the first
and 8% in the second subgroup. In patients over 45 inferior myocardial
infarction was found in 35% and in patients under 45 in 49%. In the older
group there were 40% smokers, 42% hypertensives and 39%
hypercholesterolemics, while there were 75% smokres, 35% hypertensives and
33% hypercholesterolemic patients in the younger age group. The results
show that the number of patients treated for acute myocardial infarction in
the Split region is constantly increasing (p<0.001). In patients under 45
years of age there is significantly higher inferior infarction prevalence
(p<0.001); a larger percentage of males (p<0.001) and smokers (p<0.001) and
hypercholesterolemic patients (p<0.05) was observed, as well as lower
hospital mortality rate (p<0.001).
Keywords: myocardial infarction, hospitalization
- Type of paper
: Paper in journal
Title: Platelet aggregability is associated with the extent of
myocardial infarction
- Authors:
- Mirić, Dinko
- Rumboldt, Zvonko
- Eterović, Davor
- Čapkun, Vesna
- Bagatin, Jugoslav (61246)
- Polić, Stojan (77340)
Journal: Liječnički Vjesnik
Volume: 115
Year: 1993
Pages: from 339 to 341
Number of references: 22
Language: hrvatski
Summary: The aim of this study was to evaluate the association
between the type of myocardial infarction (MI) and the circulating
platelet aggregates (circulating aggregates of thrombocytes (CAT)). The
size of MI was assessed by the maximal values of creatine-kinase (CK). In
80 patients in the acute phase of MI the values of CAT and CK were manifold
increased, mostly in 30 patients with anterospetal MI (CAT 34.1 +/- 8.3%,
CK: 920 +/- 340 IU), less markedly in 30 patients with inferior MI (CAT: 25
+/- 6.7%, CK: 739 +/' 263 IU) and in 20 patients with non-Q-wave MI (CAT:
20.7 +/- 1.9%, CK 518 +/- 224 IU). The differences between the groups were
significant (p<0.05). There was a significant linear correlation betwen CAT
and CK in anterospetal MI (r=0.57, p<0.01) and in inferior MI (r=0.54,
p<0.01=, but not in non-Q-wave MI (r=0.15, p>0.05). The results are
concordant with the hypothesis that the thrombotic event contributes more
significantly to the pathogenesis of transmural acute myocardial
infarction.
Keywords: myocardial infacrtion, platelet aggregation
- Type of paper
: Paper in journal
Title: Orthostatic hypotension - Case report of
Bradbury-Eggleston Syndome
- Authors:
- Bagatin, Jugoslav (61246)
- Sardelić, Sanda
- Rumboldt, Zvonko
- Pivac, Nediljko
- Šimunić, Miroslav
- Polić, Stojan (77340)
Journal: Liječnički Vjesnik
Volume: 115
Year: 1993
Pages: from 299 to 302
Number of references: 24
Language: hrvatski
Summary: A case of a 71-year-old women with idiopathic orthostatic
hypotension is prsented. several diagnostic procedures which can detect
sympathetic pathway lesion are reported. The value of blood pressure
measurement and heart rate response to the supine and standing position,
deep breath, Valsalva maneuver, and cold pressor test in differential
diagnosis are emphasized. The venoconstriction, venous reflexes and
tyramine tests are described, as well. The authors favour an individual
therapeutic approach with no limitation of mineralocorticoid dosage.
Nonpharmacological measures, such as an increased salt intake, elastic
support stocking and swimming are highly recommended.
Keywords: hypotension, orthostatic, treatment, diagnosis
- Type of paper
: Paper in journal
Title: An approach to a symptomatic hypotensive patient.
Orthostatic test as a guide to diagnostic and therapeutic procedure
Journal: Pharmaca
Number: 1-2
Volume: 33
Year: 1995
Pages: from 77 to 86
Number of references: 22
Language: hrvatski
- Type of paper
: Paper in journal
Title:
- Authors:
- Lukin, Ajvor
- Polić, Stojan (77340)
- Rumboldt, Zvonko
- Giunio, Lovel
Journal: Cardiologia Hungarica
Number: S3
ISSN: 0133-5596
Year: 1995
Pages: from 24 to 24
Language: engleski
Summary: Thromboembolism is one of the lethal factors in patients
with dilated cardiomyopathy (DC). A number of mechanisms have been
hypothesized, such as irregular heart rhythm, e.g. atrial fibrillation,
intracardiac thrombus and hypercoagulability in congestive heart failure.
From November 1991 to March 1995, a total of 316 patients with idiopathic
and ischaemic DC were followed up (246 males, 70 females, aged 59.06 +/-
12.49 years). Through the study period (40 months) 54 patients (17%) had at
least one episode of TE, mostly cerebrovascular. The annual rate of
thromboembolic events was 5.8%. Investigated was the frequency and site of
TE in DC, and compared was TE (+) group and TE (-) group in terms of
geneder, cavitary dimensions obtained by transthoracic echo, left
ventricular ejection fraction (EF), existence of atrial fibrillation, NYHA
functional class and plasma fibrinogen levels. No significant difference in
age, sex, functional status, basal rhythm and echocardiographic data was
found between groups. However, plasma fibrinogen levels were significantly
higher in TE(+) group (3.68 vs. 3.34 g/l, p+0.009). We conclude that higher
plasma fibrinogen levels with increased plasma viscosity and an imbalance
of coagulation/fibrinolysis process play an important role in the
pathogensis of thromboembolic events in patients with DC.
Keywords: dilated cardiomyopathy, thromboembolism
- Type of paper
: Paper in proceedings
Title: SCIROCCO ...
- Authors:
- Mirić, Dinko
- Rumboldt, Zvonko
- Lukin, Ajvor
- Kuzmanić, Ante (121695)
- Obad, Marko (122626)
- Polić, Stojan (77340)
- Rakić, Drago (121684)
Proceedings title: Proceedings of the "New frontiers" of arrhythmias 1994
Language: engleski
Place: Trento, Italy
Year: 1994
Pages: from 517 to 520
Meeting: 11th International Congress "The New Frontiers of Arrhythmias"
Held: from 01/29/94 to 02/05/94
Summary: Ambulatory electrocardiography was studied in 11
consecutive malepatients at least 10 days after acute myocardial
infarction:analyzed were the tracings obtained on the first day with
definedsouthern wind (scirocco), or viceversa. The incidence ofpremature
ventricular beats was significantly higher duringscirocco days. The
subgroup analysis, i.e. Lown I-II vs. LownIII-V grade, disclosed even
higher prevalence of the potentiallyfatal arrhythmias when scirocco was
blowing (p<0.001). It isconcluded that scirocco by largery unknown
biometeorologicalmechanisms potentiates serious cardiac arrhythmias in
coronarypatients.
Keywords: METEOROLOGICAL FACTORS, SCIROCCO, BORA, CARDIAC ARRHYTHMIAS, MYOCARDIAL INFARCTION
- Type of paper
: Paper in proceedings
Title: "
- Authors:
- Bagatin, Jugoslav (61246)
- Rumboldt, Zvonko
- Sardelić, Sanda
- Polić, Stojan (77340)
- Šimunić, Miroslav
- Naranča, Mario
Proceedings title: Proceedings of the First Croatian Congress of Pharmacology
Language: engleski
Place: Zagreb
Year: 1993
Pages: from 95 to 97
Meeting: First Croatian Congress of Pharmacology
Held: from 10/06/93 to 10/08/93
- Type of paper
: Summary in proceedings
Title: THE INCIDENCE ...
- Authors:
- Polić, Stojan (77340)
- Lukin, Ajvor
- Rumboldt, Zvonko
- Bagatin, Jugoslav (61246)
- Martinović, Duška
- Mirić, Dinko
- Pivac, Nediljko
- Rakić, Drago (121684)
Proceedings title: Abstract book
Language: engleski
Place: Ljubljana, Slovenia
Year: 1993
Pages: from 3 to 3
Meeting: 1st ALPE-ADRIA CARDIOLOGY MEETING
Held: from 05/21/93 to 05/22/93
Summary: The aim of the present study was to determine the
prevalence ofthromboembolisms in patients with dilated cardiomyopathy
(DC),especially in those with atrial fibrillation. Retrospectively,over
three years (1990-1992), the case histories of 75 inpatientswith DC (41 in
sinus rhythm and 34 in atrial fibrillation), fromClinical Hospital Split,
Croatia, were analyzed and compared tothose of 75 controls (heart failure
with no DC). The incidencesof thrombi, embolism, and mortality in both
subgroups weresimilar, while the prevalence of thromboembolic events
wassignificantly higher in the analyzed than in the control
group.Prospectively, between 6 and 18 months, from 1991 to 1993,bilirubin,
lactic dehydrogenase, prothrombin time, fibrinogendegradation products and
activated partial thromboplastin time, 1and 2-D transthoracic
echocardiography as well as clinicalstatus, in 32 successive outpatients
with DC, in the NYHA classII and III, were followed-up. There were 14
patients in sinusrhythm and 18 patients in atrial fibrillation. In only
twopatients from each subgroup thrombi were detected in the leftatrium (one
in the right ventricle!) with no systemic emboli.Five patients died in the
course of this investigation, one ofthem from presumed mesenteric embolism:
at autopsy no thrombuswas found! We conclude that thromboembolism occurs in
patientswith decompensated DC at significantly higher rate than in
otherforms of heart failure. The beneficial effects of anticoagulanttherapy
are to be expected in these patients regardless of thebasal rhythm. This
hypothesis must be assessed in a prospective,multicenter trial, however.
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Šimunić, Miroslav
- Rumboldt, Zvonko
- Polić, Stojan (77340)
- Ljutić, Dragan
- Sardelić, Sanda
- Lukin, Ajvor
Proceedings title: 2nd Alpe Adra Cardiology Meeting Abstract Book
Language: engleski
Place: Brijuni, Hrvatska
Year: 1994
Pages: from 119 to 119
Meeting: 2nd Alpe Adria Cardiology Meeting
Held: from 06/22/94 to 06/25/94
Summary: The purpose of the present study was to compare the
antihypertensive effects and electrolyte changes in outpatients with mild
to moderate essential hypertension treated with chlorthalidone or its
combination with ramipril. In a double blind study, 32 succesive
hypertensives of both sexes, 51+/-9 years old, with an average blood
pressure of 181.4-104.5 +/- 13.0/6.9 mm Hg were investigated. Following
four weeks of placebo, patients were randomly given either a combination of
5 mg ramipril with 25 mg chlorthalidone (group A, n=17), or 25 mg
chlorthalidone as monotherapy (group B, N=15). After twelve weeks of such a
treatment patients in group A had significantly lower systolic and
diastolic blood pressure than patients in group B, as shown in Table.
At the end of the trial, serum creatinine increased in group A from 87.3
+/- 12 to 93.8 +/- 16.8 umol/l (p<0.05) but was unchanged in group B. In
both groups, serum na, Ca i Mg remained unchanged during the trial. 24-hour
urinary K excretion was increased and ca excretion decreased in both
groups. Magnesiuria increased significantly in group B, while in group A it
remained unchanged. we conclude that ramipril-chlorthalidone combination
has strobger antihypertensive effect as than chlorthalidone monotherapy.
Potential magnesium-sparing effect of ramipril are yet to be assessed in
further studies.
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Bagatin, Jugoslav (61246)
- Sardelić, Sanda
- Rumboldt, Zvonko
- Polić, Stojan (77340)
- Pivac, Nediljko
Proceedings title: 2nd Alpe Adria Cardiology Meeting - Abstract Book
Language: engleski
Place: Brijuni, Hrvatska
Year: 1994
Pages: from 120 to 120
Meeting: 2nd Alpe Adria Cardiology Meeting
Held: from 06/22/94 to 06/25/94
Summary: Objective: To assess the hypothesis that long-term
antihypertensive therapy with low-dosed diuretics or beta blockers does not
induce significant untoward biochemical lesions.
Methods: In a randomized, double blind cross-over trial, 40 Ćvirgin"
essential hypertensives aged 20-65 years (52.0+/-7.9 years) with diastolic
blood pressure of 90 to 110 mm Hg were included. After the appropriate
work-up, informed consent, and a two-week placebo period, the subjects were
randomized either to hydrochlorothiazide at a dose of 25 mg o.d. or to 40
mg propranolol t.i.d. for 6 months. The next 6 months the alternative drug
was prescribed. Results are presented in table.
Conclusion: Long-term metabolic effects of HTZ or PRO in a reduced dose are
minimal and clinically insignificant.
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Mirić, Dinko
- Rumboldt, Zvonko
- Eterović, Davor
- Giunio, Lovel
- Polić, Stojan (77340)
- Božić, Ivo
- Vuković, Ivo
- Kalajzić, Ivo
Proceedings title: 2nd Alpe Adria Cardiology Meeting - Abstract Book
Language: engleski
Place: Brijuni, Hrvatska
Year: 1994
Pages: from 77 to 77
Meeting: 2nd Alpe Adria Cardiology Meeting
Held: from 06/22/94 to 06/25/94
Summary: The dymanics of circulating platelet aggregates (CPA= in
acute myocardial infarction (MI) was correlated to extent, localization and
clinical outcome. In 30 patients with acute MI, platelet aggregates were
measured on the first, third, fifth, and eight day three times a day on 5
consecutive days after MI. Twelve patients had anteroseptal MI, another 12
had inferior and the remaining 6 had non-Q MI. On the accident s day CPA
and CK values differed significantly between the three groups. In all the
patients CPA and CK returned to normal or almost normal values at the days
8 and 5 following MI, respectively. Twelve patients (40%) were
decompensated; 8 of them had anterospetal and 3 inferior MI. In 10 of the
decompensated patients (91%) and only in 2 of 19 patients that were not
decompensated (10.5%) CPA peaked at the days 3 or from the initial value.
These results suggest that platelet aggregation is significantly associated
with the severity of the MI and with the degree of heart failure.
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Giunio, Lovel
- Martinović, Duška
- Polić, Stojan (77340)
- Živković, Konstantin
Proceedings title: 2nd Alpe Adria cardiology Meeting - Abstract Book
Language: engleski
Place: Brijuni, Hrvatska
Year: 1994
Pages: from 65 to 65
Meeting: 2nd Alpe Adria Cardiology Meeting
Held: from 06/22/94 to 06/25/94
Summary: Cardiac involvement is frequent in systemic lupus
erythematosus (SLE). left ventricular systolic & diastolic function,
anatomic and functional valvular and pericardial involvement were assessed
noninvasively by M-mode, two-dimensional and Doppler echocardiography in 23
patients with SLE without clinical evidence of cardiovascular disease and
23 healthy, age and gender matched controls. Pericardial effusion was
observed in 5 patients. Mmajor endocardial damage, characterised by both
anatomical and functional valvular involvement, was observed in one patient
with valvular vegetations and in three patients with valvular reguritation.
Six patients showed only thickening of one or more valvular leaflets,
without echo-Doppler findings of valvular dysfunction. Left ventricular
systolic function, evaluated by shortening and ejection fraction, was
preserved in all patients. Left ventricular diastolic function, as
expressed by echo-Doppler transmitral flow indices of left ventricular
filling was impaired in 10 patients: compared with the control group,
patients with SLE had significantly reduced peak early diastolic flow
velocity (peak A; 50+/-7 vs 58+/-9 cm/s; p<0.01), reduced E/A ratio (1.9
+/- 0.33 vs. 1.19 +/- 0.29; p<0.01) and longer deceleration time of early
diastolic peak velocity (DTE; 134 +/- 21 vs. 186 +/- 38; p<0.05). In a
significant proportion of patients with SLE, alterations in cardiac
diastolic function as expressed by echo-Doppler transmitral flow indices of
left ventricular filling precede clinical signs of cardiac disease.
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Lukin, Ajvor
- Polić, Stojan (77340)
- Rumboldt, Zvonko
Proceedings title: 2nd Alpe Adria Cardiology Meeting - Abstract Book
Language: engleski
Place: Brijuni, Hrvatska
Year: 1994
Pages: from 138 to 138
Meeting: 2nd Alpe Adria Cardiology Meeting
Held: from 06/22/94 to 06/25/94
Summary: Patients with dilated cardiomyopathy (DC) are often victims
of sudden death, mostly due to VT/VF. Therefore 70 consecutive DC patients,
31 of which were having primary, and 31 secondary, mostly ischaemic DC,
were studied. The cavitary dimensions obtained by transthoracic
echocardiography (i.e. LVEDd, RVEDd, LA) were correlated to the heart
arrhythmias registered by ambulatory electrocardiography. in the subgroup
of primary DC patients with RVEDd above 30 mm significantly higher
incidence of VPBs was observed then in those below that limit (Lown II 67%
vs. 25%; p< 0.05). VT was more prevalent in DC patients of other etiology
if LVEDd exceeded 65 mm (Lown IV and V 25.6% vs. 11.6%; p>0.05). Both VPB
and VT incidence in this subset of patients was higher in higher NYHA
classes (III+IV:I+II = 8/11 vs. 2/29; p>0.05). We conclude that RVEDd above
30 mm in primary DC predicts an increased VPB incidence, while LVEDd above
65 mm in all DC patients is conected to an increased VT incidence, which
ulteriorly warsens in the heart failure.
- Type of paper
: Summary in proceedings
Title: Association between the platelets aggregability and the
size of myocardial infarction
- Authors:
- Mirić, Dinko
- Rumboldt, Zvonko
- Eterović, Davor
- Čapkun, Vesna
- Bagatin, Jugoslav (61246)
- Polić, Stojan (77340)
Proceedings title: Knjiga sažetaka 1. Kongresa Hrvatskog farmakoloŠkog društva
Language: hrvatski
Place: Opatija
Year: 1993
Pages: from 17 to 17
Meeting: 1. Kongres hrvatskog farmakološkog društva
- Type of paper
: Summary in proceedings
Title: Aortic dissection in a ten-year period (1983. - 1992.)
- Authors:
- Polić, Stojan (77340)
- Lukin, Ajvor
- Rumboldt, Zvonko
- Bagatin, Jugoslav (61246)
- Mirić, Dinko
- Rakić, Drago (121684)
- Forempoher, Gea
Proceedings title: Knjiga sažetaka 1. Kongresa hrvatskog kardiološkog druŠtva
Language: hrvatski
Place: Opatija
Year: 1993
Pages: from 59 to 59
Meeting: 1. Kongres hrvatskog farmakološkog društva
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Polić, Stojan (77340)
- Polić, Stojan (77340)
- Lukin, Ajvor
- Rumboldt, Zvonko
- Bagatin, Jugoslav (61246)
- Martinović, Duška
- Mirić, Dinko
- Pivac, Nediljko
- Rakić, Drago (121684)
Proceedings title: Knjiga sažetaka 1. Alpe Adria kardiološkog sastanka
Language: engleski
Place: Radenci, Slovenia
Year: 1993
Pages: from 3 to 3
Meeting: 1st ALPE-ADRIA CARDIOLOGY MEETING
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Mirić, Dinko
- Rumboldt, Zvonko
- Lukin, Ajvor
- Kuzmanić, Ante (121695)
- Obad, Marko (122626)
- Polić, Stojan (77340)
- Rakić, Drago (121684)
Proceedings title: Proceedings of 11th International Congress: The "New frontiers" of arrhythmias.
Language: engleski
Place: Marilleva, Italy
Year: 1994
Pages: from 517 to 519
Meeting: 11th International Congress "The New Frontiers of Arrhythmias"
- Type of paper
: Mentorship
Title: The effects of amiloride in the treatment of digoxin
intoxication
Faculty: Medicinski Zagreb
Mentor: POLIĆ STOJAN
Number of pages: 0
Author: Naranča Dr. med. Mario
Degree level: M.A.
- Type of paper
: Mentorship
Title: The effects of 2,3-butandione monoxime under conditions of
critical ischaemia, reperfusion, and prolonged heart isolation
Faculty: Medicinski Zagreb
Mentor: POLIĆ STOJAN
Date of defense: 04/25/95
Number of pages: 100
Author: Boban mr.sc.dr. Mladen
Degree level: Ph.D.
