- Type of paper
: Paper in journal
Title: Gangliosides and Neutral Glycosphingolipids of Human
Pancreas
- Authors:
- Đaković, Oktavija
- Jandrić, Zlata (17995)
- Mesarić, Marko (30466)
Journal: Rad Hrvatske akademije znanosti i umjetnosti, kemija
Number: 10
ISSN: 1330-0806
Volume: 462
Year: 1993
Pages: from 5 to 11
Number of references: 26
Language: engleski
Summary: The gangliosides and neutral glycosphingolipid composition
of adult human pancreas were quantiatively isolated and characterized in
autopsy material obtained from persons who died in accidents. The total
gangliosides in pancreas were 286.1 and 230.4 nmol NeuAc per g fresh
tissue. Gangliosides GM3 and GD3 were most abundant, but GM2, GM1, GD1a,
GD1b, and GT1b were also present. The molar ratio of protein- and
lipid-bound sialic acid were 2.1 and 1.8. The concentrations of neutral
glycosphingolipids were 38.3 and 44.4 nmol/g wet weight. The neutral
glycosphingolipids consisted of ceramide mono-, di-,tri-, tetrahexoside,
asialo GM1, and two compounds having more than four monosaccharides.
Keywords: gangliosides, neutral glycosphingolipids, human pancreas
- Type of paper
: Paper in journal
Title: Gangliosides and Neutral Glycosphingolipids of Human Liver
during Prenatal Development
- Authors:
- Mesarić, Marko (30466)
- Gospočić, Ljerka (13965)
- Jandrić, Zlata (17995)
- Toman, Ljiljana (31673)
Journal: Rad Hrvatske akademije znanosti i umjetnosti, kemija
Number: 10
ISSN: 1330-0806
Volume: 462
Year: 1993
Pages: from 13 to 22
Number of references: 30
Language: engleski
Summary: The gangliosides and neutral glycosphingolipids from the
fetal human liver at 16, 22, and 30 weeks of the gestation, as well as from
newborn babies' livers were quantitatively isolated and characterized. The
most striking developmental accretion of gangliosides was established
between 16 and 22 weeks of the gestation characterized by an increase of
the total gangliosides and of GM3 which represented between 76 and 83% of
total lipid-bound sialic acid. Gangliosides LM1, GM1, GD3, GD1a, and GD1b
were also present. The neutral glycosphingolipid fraction was approximately
as large as the ganglioside fraction at 16 weeks of the gestation and in
newborn babies. At 22 and 30 weeks of the gestation the concentrations of
neutral glycosphingolipids were only 50% of the gangliosides. The major
neutral glycosphingolipid was ceramide dihexoside.
Keywords: gangliosides, neutral glycosphingolipids, fetal human liver,
- Type of paper
: Paper in journal
Title: Gangliosides and Neutral Glycosphingolipids in Human Fetal
Extraneural Organs
- Authors:
- Mesarić, Marko (30466)
- Toman, Ljiljana (31673)
- Kotarski, Zvonko
Journal: Periodicum biologorum
Number: 3
ISSN: 0031-5362
Volume: 96
Year: 1994
Pages: from 211 to 218
Number of references: 35
Language: engleski
Summary: The glycosphingolipids from the human fetal lung, kidney
and adrenal gland at 16, 22, and 30 weeks of the gestation as well as from
babies who died immediately after birth were isolated and characterized.
The major ganglioside common to all organs was GM3. In the human fetal lung
and adrenal gland the other major fraction was GD3 whereas human fetal
kidney besides these two gangliosides contained a high amount of GM1, which
increased up until birth. In the neutral glycosphingolipid fractions,
ceramide mono-, di-, tri-, and tetrahexoside were detected in the human
fetal kidney and adrenal gland and the proportion of these
glycosphingolipids varied between these two organs. The kidney contained
large amounts of ceramide tetrahexosie, but ceramide dihexoside was the
major neutral glycosphingolipid in the human fetal adrenal gland.
Keywords: gangliosides, neutral glycosphingolipids, fetal lung, fetal kidney, fetal adrenal gland, (human)
- Type of paper
: Summary in proceedings
Title: Lipid modulation of cell function
- Authors:
- Mesarić, Marko (30466)
- Editors
- Varljen, Jadranka
Proceedings title: Godišnji sastanak hrvatskih biokemičara HB 94
Language: engleski
Place: Opatija
Year: 1994
Pages: from 18 to 18
Meeting: Godišnji sastanak hrvatskih biokemičara HB 94
Held: from 10/14/94 to 10/15/94
Summary: Until recently, investigations of the bewildering array of
complex cellular lipids have provided little more than promises of their
important cellular function. It has been estimated that there are more than
1000 distinct molecular species of lipids in eukariotic membranes, and this
is probably a conservative estimate. Does this imply that the exact
structures are not important, or that they are so important that even
subtle changes heve biological consequences? The answer, while incomplete,
has more to do with the breakdown products and metabolites of membrane
lipids (diacylglycerol, platelet activating-factor, phosphatidic acid,
arahidonic acid, prostaglandins, leukotrienes, eicosanoides, thromboxanes,
lipoxins, inositol phosphates, and inositol glycans) than with the lipids
themselves. Although some of these, such as diacylglycerol and phosphatidis
acid, are present constitutively in cells under resting conditions, most of
the others are generated when cells are activated.
A recent addition to this growing family of biological and physiological
active lipids emerged from investigations of sphingolipid breakdown
products. The underlying mechanisms for the sphingolipid action are not
fully understood; however, recent findings have been consistent with two
complementary paradigms: (*) complex sphingolipids (gangliosides) may
interact directly with the receptors to modulate their function; (**)
sphingolipid turnover may remove one type of bioactive compound to produce
products (including sphingosine, lysosphingolipids, and ceramides) that
serve as lipid second messengers.
Keywords: sphingolipids, lipid second messengers
- Type of paper
: Summary in proceedings
Title: Influence of Sex Steroid Hormones on the Activity of GM3
and GD3 Synthases in Rat Kidney
- Authors:
- Anić, Marijana (900054)
- Mesarić, Marko (30466)
- Editors
- Varljen, Jadranka
Proceedings title: Godišnji sastanak hrvatskih biokemičara HB 94
Language: engleski
Place: Opatija
Year: 1994
Pages: from 44 to 44
Meeting: Godišnji sastanak hrvatskih biokemičara HB 94
Held: from 10/14/94 to 10/15/94
Summary: To determine if sex steroid hormones might affect the
content and pattern of protein- and lipid-bound sialic acid, as well as the
activities of sialiltransferases I and II (SAT I and SAT II) in rat kidney
(Fisher strain, 60 days old), castrated rats were subcutaneously injected
testosterone ( 5 or 10 mg/0.1 ml DMSO), or a mixture of á-estradiol and
progesterone (1 Šg + 2 mg/0.1 ml DMSO) for four days. Another group of
castrated rats and rats without treatment were injected 0.1 ml DMSO. During
four days testosterone did not affect significantly the content of
protein-bound sialic acid. Testosterone at the highest concentration tested
actually increased total content of gangliosides, as well as relative ratio
of GD3 ganglioside, and decreased relative ratio of GM3 ganglioside.
Testosterone increased the activity of SAT II. The mixture of á-estradiol
and progesterone increased the activity of SAT I, but not the activity of
SAT II in castrated rat kidney.
Keywords: Sialoglycoproteins, gangliosides, GM3, GD3, sialyltransferase I (SAT I), sialiltransferase II (SAT II), Golgi apparatus, kidney (rat)
- Type of paper
: M.A.
Title: Influence of Sex Hormones on the Ganglioside Metabolism in
Rat Kidney
Faculty: Prirodoslovno-matematički Zagreb
Author: ANIĆ MARIJANA
Date of defense: 07/18/95
Language: hrvatski
Number of pages: 83
Summary: To determine if sex steroid hormones might affect the
content and pattern of protein- and lipid-bound sialic acid, as well as the
activities of sialiltransferases I and II (SAT I and SAT II) in rat kidney
(Fisher strain, 60 days old), castrated rats were subcutaneously injected
testosterone ( 5 or 10 mg/0.1 ml DMSO), or a mixture of á-estradiol and
progesterone (1 Šg + 2 mg/0.1 ml DMSO) for four days. Another group of
castrated rats and rats without treatment were injected 0.1 ml DMSO. During
four days testosterone did not affect significantly the content of
protein-bound sialic acid. Testosterone at the highest concentration tested
actually increased total content of gangliosides, as well as relative ratio
of GD3 ganglioside, and decreased relative ratio of GM3 ganglioside.
Testosterone increased the activity of SAT II. The mixture of á-estradiol
and progesterone increased the activity of SAT I, but not the activity of
SAT II in castrated rat kidney.
Keywords: Sialoglycoproteins, gangliosides, GM3, GD3, sialyltransferase I (SAT I), sialiltransferase II (SAT II), Golgi apparatus, kidney (rat)
- Type of paper
: Mentorship
Title: Influence of Sex Hormones on the Ganglioside Metabolism in
Rat Kidney
Faculty: Prirodoslovno-matematički Zagreb
Mentor: MESARIĆ MARKO
Date of defense: 07/18/95
Number of pages: 83
Author: Anić Marijana
Degree level: M.A.
