SVIBOR - Project code: 1-07-188

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

SVIBOR - Collecting Data on Projects in Croatia

Project code: 1-07-188


Design and Syntheses of Novel Nucleotide and Peptide Analogs and Synthetic Molecular Receptors


Main researcher: ŽINIĆ, MLADEN (55613)


Assistants
Type of research: basic
Duration from: 01/01/91. to 12/31/95.
Papers on project (total): 65
Papers on project quoted in Current Contents: 25
Institution name: Institut "Ruđer Bošković", Zagreb (98)
Department/Institute: Department of Organic Chemistry and Biochemistry Laboratory for Stereochemistry and Natural Products
Address: Bijenička 54
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (41) 428137
Fax: 385 (41) 425647
E-mail: @ini}@limp.irb.hr
Summary: Research within the present project includes two main topics: 1) nucleoside chemistry and 2) supramolecular chemistry. The topics include in particular: 1) nucleoside chemistry (a) synthesis and intra- and inter-molecular transformations of 3,4-seco-nucleosides; b) synthesis of novel azido- and phosphoramido-derivatives of nucleosides c) synthesis of modified nucleosides and dinucleosides; d) synthesis of nephroprotective derivatives of hexahydoindazol dicarboxylic acid and their complexes with cis-platinum 2) supramolecular chemistry: a) design and synthesis of molecular receptors for aromatic substrates including nucleosides and nucleotides; b) design and synthesis of fluorescence responsive molecular receptors c) synthesis of fluoroionophores d) molecular receptors for binding and transport of amino acids and peptides, e) fluorescent sensor molecules for metal cations.

Keywords: nucleosides, nucleotides, seco-nucleosides, molecular receptors, fluoroionophores

Research goals: Syntheses of different nucleoside analogs with potential anti-cancer and anti-viral activity. Synthetic modifications of the sugar part of the natural nucleosides and preparation of nucleotide analogs with modified phosphodiester bond. Synthesis of ''reversed'' nucleosides bearing nucleo-base at C-5 position of ribose unit and their use as precursors for preparation of ''double headed'' nucleoside analogs having pyrimidine or purine bases attached at C-1 and C-5 positions of a single ribose unit. Syntheses of new derivatives of tetrahydroindazolone carboxylic acid (HIDA) as potential nephroprotective agents in cis-DDP anti-cancer therapy. Design and synthesis of artificial carrier molecules for amino acids and metal cations. Design and synthesis of molecular receptors capable of binding and recognition of flat aromatic substrates including nucleosides and nucleotides. Preparation of fluorescent sensor molecules for metal cations.

COOPERATION - PROJECTS


  1. Name of project: CI 1*/0523,ECC Synthetic Molecular Receptors for Nucleo-Bases, Nucleosides and Nucleotides
    Name of institution: CNRS, College de France
    City: Paris, Francuska

COOPERATION - INSTITUTIONS


  1. Name of institution: College de France, Paris
    Type of institution: University/Faculty
    City: Paris, Francuska

  2. Name of institution: Prirodoslovno-matematički fakultet, Zagreb
    Type of institution: University/Faculty
    City: 10000 - Zagreb, Croatia

  3. Name of institution: University of Miami
    Type of institution: University/Faculty
    City: 33124 - Coral Gables, Miami, USA

  4. Name of institution: Karl-Franzens Universitat, Institut fur Experimental Physik
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Graz, Austrija

  5. Name of institution: Universitat Saarlandes Saarbrucken
    Type of institution: University/Faculty
    Type of cooperation: Joint project
    City: Saarbrucken, Njemačka

  6. Name of institution: Technische Universitat Munchen
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Munchen, Njemačka
Other information about the project.
MZT Croatian language SVIBOR Alphabetic list Sorted on project code Sorted on institutions Search help
Ministry of
Science and
Technology		 Croatian
language		 Svibor
homepage		 Alphabetic
list		 Sorted on
project code		 Sorted on
institutions		 Search Help
Last update: 10/10/95
Information: svibor@znanost.hr