SVIBOR - Project code: 1-08-082

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 1-08-082


LIVER GLYCOGEN STRUCTURE; TURNOVER OF GLYCOGEN IN BLOOD


Main researcher: LUTKIĆ, ALEKSANDAR (26940)



Assistants
Type of research: basic
Duration from: 01/01/91.

Papers on project (total): 23
Papers on project quoted in Current Contents: 4
Institution name: Veterinarski fakultet, Zagreb (53)
Department/Institute: Department of Chemistry and Biochemistry Faculty of Veterinary Medicine University of Zagreb
Address: Heinzelova 55, p.p.190
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0) 2390-300
Phone: 385 (0) 2390-300
Fax: 385 (0) 214-697

Summary: 1) LIVER GLYCOGEN STRUCTURE. Mentionable is the finding that the glycogen particle exhibits three tiers of branching i.e. during the growth of a particle branching commences three times until final size iz reached. 2) GLYCOGEN IN BLOOD. After having assayed glycogen content in whole blood in diabetics of different types and sexes, pregnant women, newborns and control subjects (N=330) the erythrocyte glycogen content was measured in the same populations. Erythrocyte glycogen shares with 8-20% in the whole blood glycogen. First series of the glycogen assay in platelets have been carried out.

Keywords: Glycogen structure,average chain length, mechanism of growth of glycogen particle; Blood glycogen, erythrocyte glycogen in diabetes, pregnancy and in neonates.

Research goals: 1) It is intended to better elucidate the mechanism of growth of glycogen particles during their growth from primer to the final size of the particle. Study of particles of the increasing size should give useful data (as the way of approach) in judging what actually proceeds during the particle's growth. Labelled precursors could help here too. 2) The distribution of glycogen among blood cells is still not known. It is to be assayed for to know the share of glycogen in erythrocytes, leukocytes, and platelets in the whole blood of control subjects and those populations with impaired or loaded carbohydrate metabolism (diabetes, pregnancy, newborns, glycogenoses).


COOPERATION - INSTITUTIONS


  1. Name of institution: Klinička bolnica "Sestre milosrdnice" Medicinskog fakulteta Sveučilišta u Zagrebu
    Type of institution: Institution whose primary activities ar
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

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Last update: 10/12/95
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