SVIBOR - Papers quoted in CC - project code: 1-08-303
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Papers quoted in Current Contents on project 1-08-303
Quoted papers: 3
Other papers: 19
Total: 22
Title: A royal jelly as a new potential immunomodulator in rats
and mice (in press)
- Authors:
- Oršolić, Nada
- Šver, Lidija
- Tadić, Zoran (143012)
- Valpotić, Ivica (66266)
- Bašić, Ivan (2406)
Journal: Comparative Immunology, Microbiology and Infectious
Diseases
Year: 1995
Number of references: 22
Language: engleski
Summary: In order to study a possible immunomodulatory effect of the
royal jelly (RJ) secreted by by mandibular and hypopharigeal glands of the
worker honeybee (Apis mellifera L.) we have used a well established rodent
model. The CBA mice were given s.c. 0.1 ml of RJ, 7 days before or
immediately after the immunization with sheep red blood cells (SRBC). The
Y59 rats received i.m. 0.4 ml or i.v. 0.025 ml of RJ once or twice at 7 day
intervals. Serum levels of total proteins and immunoglobulins in the rats
that received RJ once or twice within 2 - week period were significantly
lower (P <= 0.05) as compared with the nontreated animals. In mice which
were immunized with 4x104 of SRBC 7 days after the application of RJ the
number of plaque forming splenocyteswas significantly higher ( P<= 0,05 )
than that in the controls. Both the weight of inguinal lymf node and the
number of peripheral blood lymphocytes were increased ( P<=0,05 )in
RJ-treated mice 3or 5 days after the immunization, respectively.
Neutrophils were decreased ( P<=0,05 ) in the mice that were killed 5 or 10
days after the RJ treatment. Overall these result indicate that RJ
exhibited immunomodulatory properties by stimulating antbody production and
immunocompetent cell proliferation in mice or depressing humoral immune
function in rats. Both phenomena, though species- related in this model,
could probably be reversed by changing the dose or the route of RJ
application.
Keywords: immunomodulation, royal jelly, rat, mouse
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