SVIBOR - Project code: 3-01-015

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

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Project code: 3-01-015


BIOLOGIC EFFECTS OF ORGANIC AEROSOLS


Main researcher: ŽUŠKIN, EUGENIJA (56030)


Assistants
Type of research: applied
Duration from: 01/01/91. to 12/31/94.
Papers on project (total): 27
Papers on project quoted in Current Contents: 23
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of Health Ecology, Andrija Štampar School of Public Health Medical School University of Zagreb
Address: Rockefellerova 4
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)41 276-822
Phone: 385 (0)1-276-822
Fax: 385 (0)1-275-415
Summary: The prevalence of acute and chronic respiratory symptoms and ventilatory capacity were studied in workers exposed to different organic aerosols (cotton, hemp, wool, spices, animal food, poultry food processing, confectionary, bus drivers, fur). Significantly higher prevalence of all symptoms was found in exposed than in control workers. There were acute and chronic reductions of lung function idicating opstructive changes of ventilatory capacity in exposed workers. There was acute reduction of ventilarory capacity during the work shift, particularly for FEF25 which indicates obstructive changes located mostly in smaller airways. By comparing the measured with ventilatory capacity there was a decrease compared to control (<80%). Immunological studies indicated that immunological reactions are responsible for acute and/or chronic changes of respiratory system in industrial workers. Studies on isolated guinea pig trachea indicate that constrictive effect of occupational exposure to organic aerosols at work may be reproduced or modified by the experiments in vitro.

Keywords: Organic aerosols, textile, poultry, confectionary, bus drivers, respiratory symptoms, lung function, immunological status, isolated guinea pig trachea

Research goals: To study the prevalence of acute and chronic respiratory symptoms , lung function and immunologic status of workers occupatinally exposed to atmospheric pollution (predominantly to organic aerosols). To determine the relationship between respiratory symptoms and immunologic status and the role of their interaction in the dvelopement of brohchial hyperrreactivity and occupational lung diseases caused by organic aerosols. To analyse the effect of dust concentrations on immunological status and the developement of respiratory impairment. Though experimental studies on isolated guinea pig tracheal smooth muscle we planed to determine the mechanisms responsible for the development of respiratory and immunological changes seen in workers that were occupationally exposed to organic aerosols.

COOPERATION - PROJECTS


  1. Name of project: > Lung Function in Relation to Age and Occupation
    Name of institution: National Institutes of Health
    City: Bethesda, USA


COOPERATION - INSTITUTIONS


  1. Name of institution: National Institutes of Health
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Bethesda, USA

  2. Name of institution: Institut za medicinska istraživanja i medicinu rada
    Type of institution: State institute
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  3. Name of institution: Mount Sinai School of Medicine
    Type of institution: State institute
    Type of cooperation: Joint publishing of scientific papers
    City: New York, USA

OTHER ACHIEVEMENTS


  1. Name: nema
Other information about the project.
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