SVIBOR - Papers quoted in CC - project code: 3-01-068
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Papers quoted in Current Contents on project 3-01-068
Quoted papers: 1
Other papers: 12
Total: 13
Title: Effects of somatostatin on glucagon-stimulated
glycogenolysis and gluconeogenesis in hepatocytes cultured in vitro
- Authors:
- Roša, Jagoda (119175)
- Roša, Josip (41562)
- Fišter, Vjekoslav (12073)
ISSN: 0001-6772
Volume: 146
Year: 1992
Pages: from 205 to 211
Number of references: 28
Language: engleski
Summary: The efffects of somatostatin (SS-14) on glycogenolysis
andgluconeogenesis in rat hepatocytes cultured in vitro in aserum-free
medium were investigated. Somatostatin (122 nmol/L)did not significantly
change the basal glucose production with orwithout piruvate (10 mmol/L).
Glucagon strongly (over 100%)increased the glucose production in
hepatocytes incubated in amedium supplemented with 10 mmol/L piruvate.This
increase inglucose production is the result of increased rates
ofgluconeogenesis and glycogenolysis. Somatostatin partiallyinhibited the
glucagon stimulated increase in glucoseproduction. Glucagon also
significantly increased the glucoseproduction in a glucose-free medium
without piruvate, wichresulted from an increase of glycogenolysis.
Somatostatin did notinhibit the increase in glucose production in these
condition.After a 4 h "fast", glycogen in hepatocytes fell to a very
lowlevel. Glucose production was minimal. After the adition ofpiruvate,
there was a increase in gluconeogenesis and glucoseproduction. Glucagon
stimulated the rate of gluconeogenesis.Somatostatin completly inhibited
this glucagon-stimulatedincrease in gluconeogenesis.
Keywords: glucagon, gluconeogenesis, glycogenolysis, hepatocytes, somatostatin.
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