SVIBOR - Project code: 3-01-068

MINISTRY OF SCIENCE AND TECHNOLOGY

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tel.: +385 1 459 44 44, fax: +385 1 459 44 69
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SVIBOR - Collecting Data on Projects in Croatia

Project code: 3-01-068

Hormones and nerves modulation of insulin effects on liver in vitro

Main researcher: ROŠA, JAGODA (119175)

Assistants

ROŠA, JOSIP (41562)
ANDREIS, ANA (505)
SOLJAČIĆ, MARIJA (44082)
FIŠTER, VJEKOSLAV (12073)

Type of research: basic
Duration from: 01/01/91. to 01/31/95.

Papers on project (total): 13
Papers on project quoted in Current Contents: 1

Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of physiology Faculty of medicine University of Zagreb
Address: 41000 Zagreb, Šalata 3, p.p. 978, Croatia

Communication: Phone: 385 (0) 41 46 67 77; Fax: 385 (0) 41 42 40 01

Summary: This study investigate direct effects of insulin on amino acidtransport, glycolysis, glucose production and glycogen synthesisin hepatocytes cultured in vitro as well as interaction ofinsulin with other hormones (glucagon, somatostatin, adrenaline,noradrenaline, vasopressin, angiotensin and dexamethasone) andsympathetic nerve stimulation.

Keywords: Insulin, hepatocytes, glycogen, glycolysis, amino-acid transport.

Research goals: The aim of this study is to find out possible steps of insulin interaction with catabolic hormones, trying to resolve mechanism of insulin action. This study also investigate interplay between insulin signalling and protein kinase C, as well as role of cytosolic Ca. The results of this study will improve our understanding of insulin action at the cellular level, molecular basis of insulin action and development of insulin resistance.

Other information about the project.


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Last update: 10/16/85
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