SVIBOR - Project code: 3-01-097

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-097


PREVENTION AND TREATMENT OF HERPES-VIRUS INFECTIONS


Main researcher: SOLDO, IVAN (44060)



Assistants
Type of research: applied
Duration from: 01/01/91. to 12/31/93.

Papers on project (total): 19
Papers on project quoted in Current Contents: 5
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of infectious diseases
Address: Mirogojska c.8
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)1 4557-222
Fax: 385 (0)1 425-907

Summary: There were 40 patients with Mononucleosis infectiosa treated. The diagnosis of the disease was based on clinical and laboratory findings. The pathogen of the disease was Epstein-Barr virus. We followed: blood-count, hepatogram, antibodies to viral capside antigen and cytological analysis of lymph node needle aspiration. These were done at all patients before the treatment with acyclovir (1/3 of patients), cimetidin (1/3 of patients) and at the control group. After the treatment, according to plan, at all patients the blood count, hepatogram and control cytologic analysis of lymph node needle aspiration was made. Clinical (fever, lymphadenopathy, hepatosplenomegaly, angina) and laboratory parameters (blood count, hepatogram) were made, too. The whole programm has not been realized yet because of shortage of financial support (determination of monoclonal antibodies). One part of achieved results was presented at international scientific conferences, and the other in doctoral dissertation of the assistant in the project.

Keywords: Infectious mononucleosis, Epstein-Barr Virus, clinical and laboratory parameters, antibodies, acyclovir, cimetidin, lymphoproliferative disorder, cytological finding of lymph node needle aspiration.

Research goals: Lymphoprolipherative disorder is very common at patients with infectious mononucleosis. Our aim is to establish the efficacy of acyclovir and cimetidin (together with control group) to increasment of lymphoprolipheration based on parameters: size of lymph nodes, size of liver and spleen, changes in differential blood count andcytomorphological needle aspiration of lymph nodes. Mentioned parameters will be followed during the treatment and compared with control group. Although the project is not entirely finished as it was planned, mainly because of shortage of financial support, it can be said that mentioned drugs have the influence to frequency of lymphoprolipherative disorder in the comparison with control group.


COOPERATION - INSTITUTIONS


  1. Name of institution: Klinika za infektivne bolesti "Dr. Fran Mihaljevic"
    Type of institution: International organization
    City: 10000 - Zagreb, Croatia

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Last update: 10/15/95
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