SVIBOR - Project code: 3-01-103


Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69


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Project code: 3-01-103

preterm labour

Main researcher: KUVAČIĆ, IVAN (76361)

Type of research: applied
Duration from: 09/01/91. to 09/01/97.

Papers on project (total): 13
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: University Medical School of Zagreb Department of Obstetrycs and Gynecology Institute for Perinatal Medicine
Address: Petrova 13
City: 10000 - Zagreb, Croatia
Phone: 385 (0)444-022
Fax: 385 (0)444-279

Summary: In this project clinical and laboratory research of pregnenciesfollowed up in Obstetric out-patient unit of the Gyneacology Department UHC Zagreb was planned.The significance of genital system biocenosis for the pregnancy outcome ,child developmentand possible pathology was tested was tested by taking vaginal and endocervical smears at the first visit. Samples of the mothers blood and when indicated of childs, too,were taken et equal intervals.From this samples was extractedestradiol,progesteron,and C-reactive protein.It was also planned to assess known and possible stimulators of myometricalcontractions (prostaglndin F2 alfa,prostaglandin E2,prostaciklin, tromboksan,interleukin 1 alfa and leukotrien B4),with a parallel observation of mechanical and electrical uterine activity. Our goal was to obtain insight into the dynamics of theseparametars during term pregnancy as well duringintraamniotic infection or preterm uterineactivity.Irregularities of these parametars were followed up inpregnancies with symptoms of preterm delivery and treatment andtherapy assessed accordingly. In vitro research was planned in the experimental part. 1/The contractility of human myometrium in media with various tocolytic concetrations.2/Electronic-mycroscope reseach ofcontact junctions.3/Production of myometrical contractionstimulator,human amnion,and decidua in the tissue culture.

Keywords: Preterm delivery,prostaglandini,tocolysis,uterine muscle electromyography,chorioamnionitis.

Research goals: The goal of our proposed research was to: 1/Assess the correlation of genital bacterial flora in pregnancy and premature delivery.The results are beeing processed. 2/Assess pregnancy with intraamniotic infection in correlation with the genital bacterial flora,the importance and reliability of clinical and biochemical parametars in intraamniotic infection diagnosis.The results are been elaborated and published(see under publications). 3/Assess the benefit of confirmed myometral contraction inhibitors and their influence on the mother and the child(within etnical limits).The results are beeing processed and future research planned. 4/Assed the importance of the detection the characteristic of the electrical and consequential mechanical uterine activity for the begining of labor(preterm and term).Preliminary results have been published(see under publications).


  1. Name of institution: Klinika za ginekologiju i opstetriciju
    Type of institution: University/Faculty
    City: Insbruck, Austrija

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Last update: 03/10/94