SVIBOR - Project code: 3-01-147

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-147


The Role of Guanidines and Purines in the Etiology of Diabetes Mellitus


Main researcher: ROČIĆ, BORIS (41255)



Assistants
Type of research: basic
Duration from: 01/01/91. to 01/01/94.

Papers on project (total): 40
Papers on project quoted in Current Contents: 8
Institution name: Institut za dijabetes, endokrinologiju i bolesti metabolizma "Vuk Vrhovac", Zagreb (45)
Department/Institute: Department of Laboratory Medicine
Address: Dugi dol 4a
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)12332222
Fax: 385 (0)12331515

Summary: The aim of this investigation is the study of biogenetic compounds: 1) guanidine substances and 2) purines, and its specific role in the etiology of diabetes mellitus. The research on guanidine compounds, particularly creatine, should clarify the exact role of this class of biogenetic substances and its influence on the glucose metabolism in diabetics. Investigation of the oxidative products of purine metabolism, particularly of uric acid, would enable the evaluation of the biogenetic hypothesis which postulates that alloxan, the product of uric acid oxidation, is the responsible species which causes the irreversible damage of the B - cell of Langerhans islets.

Keywords: creatine, glycation, purines, uric acid, alloxan-like compounds

Research goals: Specific goals: 1. The goal of the investigation was to establish the role ofbiogenetic guanidine compounds on glucose and insulin homeostasisin diabetics. 2. The goal of the investigation was to prove thehypothesis on the relation between the B-cytotoxic products ofpurine oxidation and etiology of diabetes mellitus. Investigations of biogenetic compounds and the relationshipbetween the chemical structure and biological activity areprovocative targets in biochemical and medicinal research, with afar reaching importance in both etiology and therapy of diabetesmellitus.


COOPERATION - INSTITUTIONS


  1. Name of institution: Medicinski fakultet
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  2. Name of institution: Department of Clinical Biochemistry
    Type of institution: International organization
    Type of cooperation: Systematic exchange of information
    City: Oxford, Velika Britanija

  3. Name of institution: Institut Ruđer Bošković
    Type of institution: State institute
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

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Last update: 09/20/95
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