SVIBOR - Papers quoted in CC - project code: 3-01-159

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SVIBOR - Collecting Data on Projects in Croatia

Papers quoted in Current Contents on project 3-01-159

Quoted papers: 5
Other papers: 53
Total: 58

Title:

Authors:: Župan, Gordana (142160); Mršić, Jasenka (142272); Simonić, Ante (43222)

Journal: Arch int Pharmacodyn Ther
ISSN: 0003-9789
Volume: 325
Year: 1993
Pages: from 61 to 69
Language: engleski
Summary: The effects of various doses (0.03, 0.1, 0.3 or 1 mg/kg) of thecalcium channel blockers nicardipine, felodipine and nifedipineon the learning ability in intact rats and on hypoxia-inducedretention deficits were examined. All animals were trained in apassive avoidance procedure. The drugs tested had been injected30 minutes before the learning trial started. Some animals wereexposed to a hypoxic condition immediately after the learningtrial response had been acquired. A passive avoidance retentiontest was performed 24 hours later. It was found that hypoxiastrongly impaired the retention of the passive avoidanceresponse. Nicardipine, felodipine and nifedipine did notinfluence the passive avoidance behavior in the intact animals,but significantly improved the retention deficits in the animalsexposed to hypoxia. The effects of the substances tested weredose-dependent. These findings support the hypothesis thatperturbations in calcium homeostasis can contribute to the memorydeficits associated with hypoxic conditions.
Keywords: cerebral hypoxia, nicardipine, felodipine, nifedipine, passiveavoidance behavior, rat

Title:

Authors:: Župan, Gordana (142160); Varljen, Jadranka; Eraković, Vesna; Mršić, Jasenka (142272); Križ, Jasna; Simonić, Ante (43222)

Journal: Croatica Chemica Acta
ISSN: 0011-1643
Volume: 68
Year: 1995
Pages: from 485 to 490
Language: engleski
Summary: The aim of this study was to examine the dynamics of the brain free fatty acid (FFA) pool in rats exposed to : a) controlled hypoxia, and b) experimental epilepsy. Animals from group (a) were subjected to hypoxia procedure. Immediately, 5, 15 or 60 minutes after losing the righting reflex, the animals were decapitated and brains were quickly removed. Animals from group (b) received penicillin (5000 U/5ul) into the left lateral ventricle and were decapitated immediately, 5 or 15 minutes after the appearance of epileptic seizures. The FFA were quanified by gas chromatography. An increase in the total brain FFA content with the maximum level at 60 minutes after losing the righting reflex was detected in hypoxia-exposed rats. The highest level of the brain free arachidonic acid (FAA) was detected 15 minutes after hypoxia. Seizures also produced an increase in the total brain FFA and brain FAA, with a statistically significant level 5 minutes after the appearance of epileptic seizures.
Keywords: cerebral hypoxia, epilepsy, brain free fatty acids, rat


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