MINISTRY OF SCIENCE AND TECHNOLOGY
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E-mail: ured@znanost.hr
Title: Zaštita acetaminofenom infucirane hepatotoksičnosti u miša
prostaglandinom E
Journal: Eur J Clin Pharmacol
Number: 2
ISSN: 0353-9296
Volume: 1
Year: 1991
Pages: from 59 to 64
Number of references: 32
Language: engleski
Summary: Acetaminophen (AAP) administrated to mice via gastric tube
in adose od 300-350 mg/kg induced heavy liver injury and killed55-80% mice
within 48 hours. PGE2, given intraperitonealy 15-30minutes before AAP,
ameliorated the liver injury and reduced themortality in mice to 20-30%.
PGE2 also significantly reduced theincrease in plasma transaminase levels
induced by AAP. In thesame doses, PGE1 delayed the death of mice but had no
significanteffect on total mortality. Pretreatment of mice with
indomethacinhad no effect on AAP toxicity, while pretreatment of mice
withspecific anti PGE2 antibodies increased this toxicity. Thus, PGE2was
concluded to have a protective role in AAP-inducedhepatotoxicity.
Keywords: Prostaglandins E, Acetaminophen, Hepatitis, Toxic
Title: Effect of propranolol on urinary prostaglandin E2
excretion and renal interlobar arterial blood flow after furosemide
administration in patients with liver cirrhosis
Journal: Eur J Clin Pharmacol
Volume: 43
Year: 1992
Pages: from 555 to 558
Number of references: 17
Language: engleski
Summary: The effect of propranolol on furosemid-stimulated urinary
PGE2excretion and renal blood flow was evaluated in 12 patients
withalcoholic liver cirrhosis. Urine volume and sodium excretionafter
furosemide administration were not influenced bypropranolol pretreatment.
The results demonstrate thatpropranolol pretreatment significantly
influenced thefurosemide-induced increase in urinary PGE2 excretion and
renalinterlobar arterial blood flow in cirrhotic patients.
Keywords: Propranolol, Furosemide, Prostaglandin E2, interlobar arterial blood flow, cirrhosius, drug interactio
Title: The effect of interleukin 1 alfa on acetaminophen induced
hepatotoxicity
ISSN: 1043-4666
Volume: 5
Year: 1993
Pages: from 192 to 197
Number of references: 38
Language: engleski
Summary: The protective effect of interleukin 1 alfa in mice
withacetaminophen induced hepatitis was investigated. IL 1alfa had
asignificant protective effect if given 2 or more hours beforeAAP; it
significantly reduced mortality of mice and decreasedserum transaminase
level. Pretreatment with indomethacin did notabrogate significantly the
protective effect of IL1. Thus, thehepatoprotective effect of IL 1alfa can
not be entirely explainedby stimulation of prostaglandin synthesis.
Keywords: interleukin 1alfa, acetaminofen/hepatitis, leukotrien C4
Title: The effect of propranolol on thyreoid hormone
concentration in patients with liver cirrhosis
Journal: Medica jadertina
ISSN: 0351-0093
Volume: 20
Year: 1990
Pages: from 97 to 100
Number of references: 8
Language: hrvatski
Summary: The effect of propranolol on thyriod hormons in 7
healthysubjects and 10 patients with histologically proven livercirrhosis
was investigated. In healthy subjects propranolol ledto a significant
reduction of T3 concentration, while in patientswith liver cirrhosis no
significant changes were found. Authorsconcluded that in patients with
liver cirrhosis propranololadministration did not deteriorate thyreoid
hormoneconcentrations.
Keywords: propranolol, hhyroid hormones, liver cirrhosis
Title: The effect od selective and non-selective
beta-adrenoceptor blockade on the portal blood flow in patients with liver
cirrhosis and portal hypertension
Journal: Medica jadertina
ISSN: 0351-0093
Volume: 21
Year: 1991
Pages: from 41 to 46
Number of references: 11
Language: hrvatski
Summary: The effect of atenolol and propranolol on portal blood flow
wasstudied in 10 patients with liver cirrhosis and portalhypetrtension bz
using an duplex Doppler system. Atenolol andpropranolol produced
significant decrease in portal vaincross-section area, portal blood
velocity, and calculated volumeof the portal blood flow. The study
confirming important effectof bloth selective and non-selective
beta-blockers on portalhemodynamics in cirrhotics with portal hypertension
suggestingthat non-selective beta-blockers such as propranolol might bemore
effective than selective beta-blockers.
Keywords: atenolol, propranolol, portal blod flow, cirrhosis, portal hypertension
Title: Effect of verapamil on portal blood flow in patients with
liver cirrhosis
Journal: Ultrasound Med
ISSN: 0278-4297
Volume: 11
Year: 1992
Pages: from 517 to 520
Number of references: 16
Language: engleski
Summary: The effect of acute and prolonged verapamil administration
onportal blood flow was studied in 12 patients with histologicallyproved
alcoholic liver cirrhosis. The results demonstrated thatverapamil did not
alter portal blood flow in patients withalcoholic liver cirrhosis.
Keywords: verapamil, portal hypertension, portal blood flow
Title: The effect of propranolol on thyroid function in patients
with liver cirrhosis
Journal: Z Gastroenterol
Volume: 29
Year: 1991
Pages: from 286 to 288
Number of references: 19
Language: njemački
Summary: The effect of propranolol on thyroid hormones of 7
healthysubjects and 10 patients with histologically proven livercirrhosis
was investigated. In healthy subjects propranololadministration led to a
significant reduction of T3 serum levels,while in patients with liver
cirrhosis no significant changes inT3 and FT4 were found. In patients with
liver cirrhosispropranolol administration did not affect thyroid hormone
levels.
Keywords: Liver cirrhosis, Propranolol, Thyroxine, Triiodthyronine
Title: Portal venous flow in response to verapamil treatment in
patients with liver cirrhosis
Proceedings title: International gastro-surgical club
Language: engleski
Place: Atena
Year: 1990
Pages: from 0 to 0
Meeting: 2nd IGSC meeting of surgeons and gastroentherologists
Held: from 11/14/90 to 11/17/90
Summary: Verapamil has been considered as a potentially useful agent
inthe treatment of portal hypertension. This study is intended
toinvestigate the effects of verapamil administration on portalvein
hemodynamics in 7 patients with histologicaly provencirrhosis by means of
pulsed Doppler system. This studydemonstrated that in patients with liver
cirrhosis verapamiladministration did not alter portal venous flow.
Keywords: verapamil, liver cirrhosis, portal blood flow
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