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Summary: The objective of the study is assessment of the adnexal
tumor vascularization with transvaginal color and pulsed Doppler
sonography. Vessel location, its arrangement and pulsed Doppler waveform
characteristics will be used to distinguish benign from malignant
vascularity. Study is designed as prospective one in which sonographic and
personal records of all women in this period will be investigated.
Keywords: Transvaginal color and pulsed Doppler, ovarian tumors, neovascularization
Research goals: Although there has been significant progress in the
surgery, radiotherapy and chemotherapy of ovarian carcinoma the mortality
rate has not decreased appreciable in the past 20 years. Indeed, more
fundamental and logical step is the early detection of cancer in
asymptomatic women by screening. As there is no known precursor, any
screening test will have to be sensitive for early cancer, as well as being
highly specific. Such a test must be evaluated for validity and
acceptability and would than have to be incorporated in a trial of
screening efficacy, with mortality from the disease as the end-point.
A number of different screening methods have been applied in an
international trials during the last five years. Among thousands of women
screened and many operated on, only a few had cancers that were detected.
Most of detected tumors were already advanced, had border-line pathologic
features suggesting indolent biologic behavior, or were already associated
with a clinically identifiable pelvic mass. Obviously, efforts are
continuing and its seems that some improvement can be expected using
transvaginal color and pulsed Doppler.