SVIBOR - Project code: 3-01-237

MINISTRY OF SCIENCE AND TECHNOLOGY

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Project code: 3-01-237


IMMUNOTHERAPY OF HYPERSENSITYVIT TO POLLEN OF PARIETARIE OFFICINALIS


Main researcher: CVITANOVIĆ, SLAVICA (95193)



Assistants
Type of research: applied
Duration from: 01/01/95.

Papers on project (total): 4
Papers on project quoted in Current Contents: 3
Institution name: Bolnica "Firule", Split (141)
Department/Institute: Department of Pulmonary Diseases
Address: Spinčićeva 1
City: 21000 - Split, Croatia
Communication

Summary: Abstract the pattern of allergy on the East Adriatic coast was investigated in a large number of patients. Parietaria officinalis pollen allergen was found the causative factor in more than 60% of patients. In area have experianced a considerable immigration from the inland (where there is no P. officinalis), the pattern of reactivity in P. officinalis pollen hyperreactive patients was compared in autochtonous population and newcomers to the area, with rather significant findings: in the course of time, the specific reactivity decreases in autochtons and increases in the newcomenrs to the area. Specific desensitization (immunotherapy, IT) was applied to treat 50 patients with pollen rhinitis due to hypersensitivity to P. officinalis pollen. Three times a year, the following parameters were determined: skin testing with inhalation allergens and the causative allergen, total IgE, allergen specific IgE, specific blocking IgG, histamine released after provocation with specific allergen and eosinophils in the peripheral blood. The patients noted their symptoms and additionally taken therapy during the pollination season (March September). The IT was applied yearly, for three years, from November to March. The results obtained proved rather promising with respect to mitigation of the symptoms. The respective mechanisms appeared to lay in the decrease of IgE and increase of the IgG antiallergen antibody concentrations. Correspondingly, the concentration of histamine after provocation was diminished in patients treated by IT.

Keywords: Hyposensitization, Prist IgE, RAST IgE, IgG blocking antibodies, histamin, intracutaneous test, Prietaria officinalis.

Research goals: General aim of the study is an assessment of the efficacy of treatment of hypersensitivity to P. officinalis by hyposensitization, and analysis of mechanisms underlying the achieved effects (mitigation of the symptoms during the pollination season).

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Last update: 10/05/95
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