IMMUNOTHERAPY OF HYPERSENSITYVIT TO POLLEN OF PARIETARIE OFFICINALIS
Main researcher
: CVITANOVIĆ, SLAVICA (95193) Assistants
ZEKAN, LJUBIMKA (137572)
Type of research: applied Duration from: 01/01/95. Papers on project (total): 4
Papers on project quoted in Current Contents: 3
Institution name: Bolnica "Firule", Split (141) Department/Institute: Department of Pulmonary Diseases Address: Spinčićeva 1 City: 21000 - Split, Croatia
Communication
Summary: Abstract the pattern of allergy on the East Adriatic coast
was investigated in a large number of patients. Parietaria officinalis
pollen allergen was found the causative factor in more than 60% of
patients. In area have experianced a considerable immigration from the
inland (where there is no P. officinalis), the pattern of reactivity in P.
officinalis pollen hyperreactive patients was compared in autochtonous
population and newcomers to the area, with rather significant findings: in
the course of time, the specific reactivity decreases in autochtons and
increases in the newcomenrs to the area. Specific desensitization
(immunotherapy, IT) was applied to treat 50 patients with pollen rhinitis
due to hypersensitivity to P. officinalis pollen. Three times a year, the
following parameters were determined: skin testing with inhalation
allergens and the causative allergen, total IgE, allergen specific IgE,
specific blocking IgG, histamine released after provocation with specific
allergen and eosinophils in the peripheral blood. The patients noted their
symptoms and additionally taken therapy during the pollination season
(March September). The IT was applied yearly, for three years, from
November to March. The results obtained proved rather promising with
respect to mitigation of the symptoms. The respective mechanisms appeared
to lay in the decrease of IgE and increase of the IgG antiallergen
antibody concentrations. Correspondingly, the concentration of histamine
after provocation was diminished in patients treated by IT.
Research goals: General aim of the study is an assessment of the
efficacy of treatment of hypersensitivity to P. officinalis by
hyposensitization, and analysis of mechanisms underlying the achieved
effects (mitigation of the symptoms during the pollination season). Other information about the project.