ETHYOPATHOGENESIS OF THYROID AND PARATHYROID TUMOURS AND AUTOIMMUNE DISEASES
Main researcher
: ŠIMONOVIĆ, IVAN (46830) Assistants
BUHBERGER-HORVAT, KATICA (130572)
ČREPINKO, INGA (8420)
PAVLINOVIĆ, ŽELJKA (130561)
VLATKOVIĆ, MILENKO (52691)
BENCE-ŽIGMAN, ZDENKA (130816)
LATKOVIĆ, IVAN (25441)
ŠKREB, FRANJO (42912)
TOMIĆ-BRZAC, HRVOJKA (130805)
HALBAUER, MIRA (141313)
KASAL, BOŽIDAR (60664)
Type of research: applied Duration from: 01/01/91. to 12/31/93. Papers on project (total): 1
Institution name: KBC, Znanstvena jedinica za nuklearnu medicinu i zaštitu od zračenja, Zagreb (158) Department/Institute: CLINICAL DEPARTEMENT OF NUCLEAR MEDICINE AND RADIATION PROTECTION Address: KBC REBRO, Kišpatićeva 12 City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)41 23 33 850
Fax: 385 (0)41 23 57 85
Summary: The aim of research was to explain etiopathogenesis of
tumors and autoimmunological diseases of thyroid and parathyroid glands,
which causes changes morphological, functional and immunological disorders
of these organs. Immunological thyroid disease may result in characteristic
functional disorders which manifested as hyperthyreosis or hypothyreosis.
Simultaneous determination of TSH values in several specimens by
luminoimmunometric analysis in the dry spot makes possible the detection of
congenital hypothyreosis in the first days of life already. We found the
high sensitivity and specifity of echographical and cytological methods in
the diagnosis of malignant thyroid tumors up to 10 mm in size, which
provides the new approach in studying small thyroid carciomas. It was
proved that by ultrasound-guided fine needle aspiration biopsy can detect
and confirma subacute thyroid inflammation and that the vaule of the
combined procedure is superior to US examination of enlarged parathyroid
glands were determined. Quantitative morphometric image analysis was for
the first time on parathyroid aspirate performed. It was concluded that
high sensitivity of cytodiagnosis in preoperative identification of
parathyroid tumore helps to establish a higher precision in categorization
of patients with hyperparathyroidism.
Research goals: The objective was to investigate histiogenesis of
these pathological processess of the thyroid and parathyroid gland which
are manifested by morphologic and immune disorders. Distinguishing tumors
from nontumorous changes in the thyroid and especially interpretetation of
nontumorous changes with proliferation have manifold meaning. Cytologic
and echographic changes in inflammatory diseases of thyroid and
parathyroid glands were investigated, and methods for determination of
free thyroid hormones in the serum were used for more precise insight in
the functional state of the thyroid. These investigations enabled the
systematisation of morphologic methods and the comparison of their results
with pathohistology. This makes possible the early diagnosis of thyroid
and parathyroid disoreders. Our study confirmed that using macro- and
micromorphologic, chemical, nuclear-medicine and immunological tests makes
possible the detection and characterization of thyroid and parathyroid
pathologic process nature, as well as the application of successful
therapy. Other information about the project.