SVIBOR - Project code: 3-01-247

MINISTRY OF SCIENCE AND TECHNOLOGY

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Project code: 3-01-247


ETHYOPATHOGENESIS OF THYROID AND PARATHYROID TUMOURS AND AUTOIMMUNE DISEASES


Main researcher: ŠIMONOVIĆ, IVAN (46830)



Assistants
Type of research: applied
Duration from: 01/01/91. to 12/31/93.

Papers on project (total): 1
Institution name: KBC, Znanstvena jedinica za nuklearnu medicinu i zaštitu od zračenja, Zagreb (158)
Department/Institute: CLINICAL DEPARTEMENT OF NUCLEAR MEDICINE AND RADIATION PROTECTION
Address: KBC REBRO, Kišpatićeva 12
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)41 23 33 850
Fax: 385 (0)41 23 57 85

Summary: The aim of research was to explain etiopathogenesis of tumors and autoimmunological diseases of thyroid and parathyroid glands, which causes changes morphological, functional and immunological disorders of these organs. Immunological thyroid disease may result in characteristic functional disorders which manifested as hyperthyreosis or hypothyreosis. Simultaneous determination of TSH values in several specimens by luminoimmunometric analysis in the dry spot makes possible the detection of congenital hypothyreosis in the first days of life already. We found the high sensitivity and specifity of echographical and cytological methods in the diagnosis of malignant thyroid tumors up to 10 mm in size, which provides the new approach in studying small thyroid carciomas. It was proved that by ultrasound-guided fine needle aspiration biopsy can detect and confirma subacute thyroid inflammation and that the vaule of the combined procedure is superior to US examination of enlarged parathyroid glands were determined. Quantitative morphometric image analysis was for the first time on parathyroid aspirate performed. It was concluded that high sensitivity of cytodiagnosis in preoperative identification of parathyroid tumore helps to establish a higher precision in categorization of patients with hyperparathyroidism.

Keywords: thyroid, parathyroid, morphology, immunology, diagnostic

Research goals: The objective was to investigate histiogenesis of these pathological processess of the thyroid and parathyroid gland which are manifested by morphologic and immune disorders. Distinguishing tumors from nontumorous changes in the thyroid and especially interpretetation of nontumorous changes with proliferation have manifold meaning. Cytologic and echographic changes in inflammatory diseases of thyroid and parathyroid glands were investigated, and methods for determination of free thyroid hormones in the serum were used for more precise insight in the functional state of the thyroid. These investigations enabled the systematisation of morphologic methods and the comparison of their results with pathohistology. This makes possible the early diagnosis of thyroid and parathyroid disoreders. Our study confirmed that using macro- and micromorphologic, chemical, nuclear-medicine and immunological tests makes possible the detection and characterization of thyroid and parathyroid pathologic process nature, as well as the application of successful therapy.

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Last update: 10/09/95
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