SVIBOR - Project code: 3-01-259

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-259


EPIDEMIOLOGICAL RESEARCHES OF BALKAN ENDEMIC NEPHROPATHY


Main researcher: ČEOVIĆ, STJEPAN (59193)


Assistants
Type of research: applied
Duration from: 01/01/91. to 12/15/95.
Papers on project (total): 5
Papers on project quoted in Current Contents: 4
Institution name: Opća bolnica "Dr.Josip Benčević", Znanstvena jedinica, Slavonski Brod (184)
Department/Institute: Scientific unit General Hospital "Dr. Josip Benčević"
Address: Andrije Štampara 42
City: 35000 - Slavonski Brod, Croatia
Communication
Phone: 385 (0)35-232-228
Fax: 385 (0)35-242-331
Summary: Balkan endemic nephropathy (BEN) is a chronical and progressive disease of kidneys with death outcome. Ethiology and pathogenesis are unknown. No doubt the disease exists in rural area, avoiding towns, both the autochonous inhabitants and seltlers are affected by it. Thus speaking in favour of harmful influence of the environment on the health of people. The observation of the frequency of the disease in the long span of time enables the insight into its dynamics as well as into conception if the disease is spreading out of its focus or if it is vanishing in the places where it had been present. This knowledge could be significant contribution to enlightening of ethiology. On the bases of hospital records and Death records office as well as cytological analysis of urine sediment the degree on the bond of BEN and epithel tumours of pyelon and urethers will be estimated. The examination of kidneys by ultrasound is predicted. All inhabitants of Kaniža village under 30 will be examined in this way because of the comparison with the same findings 5 years ago. While this is being done the attention will be focused on possible decrease of kidney body, especially parenhim.

Keywords: Balkan endemic nephropathy, incidence, prevalence, specific death rate, tumours.

Research goals: Observe the frequency of the disease in the existing endemicfocus through longer period of time as well as possiblephenomenon of spreading to the neighbouring villages. The changeof intensity of endemia or even its cyclic appearance can besignificant argument in favour of understanding it as the diseaseof the natural focus. On the contrary if the disease remainsconstantly present with more or less the same intensity, ifit does not disappear not even in one village or in one part ofthe area in focus and if it does not appear in a new area, thearguments will speak in favour of untransferable agentrespectivelly toxin. Find the frequency of epithel tumours of urethers in endemic as well as in control area.

COOPERATION - PROJECTS


  1. Name of project: JF 937-31 Endemic nephropathy, cancer of the kidney and environment
    Name of institution: Case Western Reserve University, School of Medicine, Department of Medicine and Department of environmental Health Sciences, Cleveland
    City: Cleveland, USA

COOPERATION - INSTITUTIONS


  1. Name of institution: Zavod za kliničko-laboratorijsku dijagnostiku KBC-Rebro
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  2. Name of institution: Institut za medicinska istraživanja i medicinu rada
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  3. Name of institution: Case Western Reserve University, School of Medicine, Department of Medicine and Department of Environmental Health Sciences, Cleveland, OHIO, USA
    Type of institution: University/Faculty
    Type of cooperation: Occasional exchange of experts
    City: Cleveland, USA
Other information about the project.
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Last update: 10/20/95
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