SVIBOR - Papers quoted in CC - project code: 3-01-433
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Papers quoted in Current Contents on project 3-01-433
Quoted papers: 3
Other papers: 42
Total: 45
Title: LESIONS OF THE NUCLEUS BASALIS MAGNOCELLULARIS IN IMMATURE
RATS:SHORT-AND LONG-TERM BIOCHEMICAL AND BEHAVIORAL CHANGES
- Authors:
- Župan, Gordana (142160)
- Casamenti, Fiorella
- Scali, Carla
- Pepeu, Giancarlo
Journal: Pharmacology,Biochemistry and Behavior
ISSN: 0091-3057
Volume: 45
Year: 1993
Pages: from 19 to 25
Number of references: 32
Language: engleski
Summary: Short- and long-term effects of unilateral lesions of the
nucleusbasalis magnocellularis (NBM) on cortical cholineacetyltransferase
(ChAT) activity and passive avoidanceconditioned responses were examined in
immature rats. The lesionswere made by stereotaxic injection of quisqualic
acid onpostnatal days 14 (P14), 17 (P17), and 21 (P21). A marked loss
ofChAT activity was found 7 days after surgery in all age groups oflesioned
rats. Unoperated P14 rats were unable to perform thepassive avoidance
conditioned responses. Acquisition began onP17. Lesions made on P17 and P21
strongly impaired theacquisition and retention of the task, evaluated 7
dayspostoperation. No biochemical but a partial behavioral recoverywas
observed 3 months after surgery in rats lesioned on P14. Onthe contrary,
despite a persistent decrease in cortical ChATacitivity, rats lesioned on
P21 were able to acquire and retainthe passive avoidance conditioned
response. These resultsindicate that destruction of NBM cholinergic neurons
shortlyafter birth is not compensated for by the developmentalplasticity of
the residual neurons but results in permanentcholinergic hypofunction. They
also demonstrate that cholinergicNBM neurons play an important role in the
acquisition andretention of a passive avoidance task, nevertheless, a
behavioralrecovery may take place 3 months after the lesion, even in
thepresence of a persistent cholinergic hypofunction.
Keywords: immature rats, lesions of the nucleus basalis magnocellularis, choline acetyltransferase, passive avoidance conditioned response, postnatal recovery
Title: EFFECTS OF NICARDIPINE, FELODIPINE AND NIFEDIPINE ON
PASSIVE AVOIDANCE BEHAVIOR OF INTACT AND HYPOXIA-EXPOSED RATS
- Authors:
- Župan, Gordana (142160)
- Simonić, Ante (43202)
- Mršić, Jasenka (142272)
Journal: Archives internationales de Pharmacodynamie et de Therapie
Number: 1
ISSN: 0003-9780
Volume: 325
Year: 1993
Pages: from 61 to 69
Number of references: 26
Language: engleski
Summary: The effects of various doses (0.03, 0.1, 0.3 or 1 mg/kg) of
thecalcium channel blockers nicardipine, felodipine and nifedipineon the
learning ability in intact rats and on hypoxia-inducedretention deficits
were examined. All animals were trained in apassive avoidance procedure.
The drugs tested had been injected30 minutes before the learning trial
started. Some animals wereexposed to a hypoxic condition immediately after
the learningtrial response had been acquired. A passive avoidance
retentiontest was performed 24 hours later. It was found that
hypoxiastrongly impaired the retention of the passive avoidanceresponse.
Nicardipine, felodipine and nifedipine did notinfluence the passive
avoidance behavior in the intact animals,but significantly improved the
retention deficits in the animalsexposed to hypoxia. The effects of the
substances tested weredose-dependent. These findings support the hypothesis
thatperturbations in calcium homeostasis can contribute to the
memorydeficits associated with hypoxic conditions.
Keywords: cerebral hypoxia, nicardipine, felodipine, nifedipine, passive avoidance behavior, rat
Title: ACCUMULATION DYNAMICS OF THE BRAIN TOTAL FREE FATTY ACIDS
AND FREE ARACHIDONIC ACID IN THE MODELS OF CEREBRAL HYPOXIA AND EPILEPSY IN
RATS
- Authors:
- Župan, Gordana (142160)
- Varljen, Jadranka (85515)
- Eraković, Vesna
- Mršić, Jasenka (142272)
- Križ, Jasna
- Simonić, Ante (43202)
- Milin, Čeda (70123)
Journal: Croatica Chemica Acta
Number: 3
ISSN: 0011-1643
Volume: 68
Year: 1995
Pages: from 485 to 490
Number of references: 14
Language: engleski
Summary: The aim of this study was to examine the dynamics of the
brain free fatty acid (FFA) pool in rats exposed to : a) controlled
hypoxia, and b) experimental epilepsy. Animals from group (a) were
subjected to hypoxia procedure. Immediately, 5, 15 or 60 minutes after
losing the righting reflex, the animals were decapitated and brains were
quickly removed. Animals from group (b) received penicillin (5000 U/5ul)
into the left lateral ventricle and were decapitated immediately, 5 or 15
minutes after the appearance of epileptic seizures. The FFA were quanified
by gas chromatography. An increase in the total brain FFA content with the
maximum level at 60 minutes after losing the righting reflex was detected
in hypoxia-exposed rats. The highest level of the brain free arachidonic
acid (FAA) was detected 15 minutes after hypoxia. Seizures also produced an
increase in the total brain FFA and brain FAA, with a statistically
significant level 5 minutes after the appearance of epileptic seizures.
Keywords: cerebral hypoxia, epilepsy, brain free fatty acids, rat
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