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Title: Normal labour
Title: Induced labour
Title: Induced labour
Title: Caesarean section in management of preterm delivery
Title: Effect of atrazine ingested prior to mating on rat females
aand their offspring
Title: The Pink Zones in Croatia: The Fate of Handicapped
Children from Vrlika
Title: Programmed inductions of deliveries at the Department od
gynecology and obstetrics of the Clinical hospital Split
Title: Adolescent parents and development of progeny in rats
Title: UMBILICAL AND CEREBRAL BLOOD FLOW IN RELATION TO
COMPUTERIZED FETAL HEART RATE ANALYSIS IN SMALL FOR GESTATIONAL AGE FETUSES
Title: Clinical value of the umbilical artery resistance index in
the prediction of the morbidity of small for gestational age fetuses
Title: THE ROLE OF SERUM PROGESTERONE AND ESTRADIOL, ENDOMETRIAL
BIOPSY AND ULTRASOUND IN EVALUATION OF LUTEAL PHASE OF MENSTRUAL CYCLE
Faculty: MEDICINSKI FAKULTET SVEUČILIŠTE U ZAGREBU
Author: POLJAK BORIS
Date of defense: 03/31/94
Language: hrvatski
Number of pages: 124
Summary: Taking into account selection criteria, 35 women with
corpus luteum insufficiency and 15 women with its normal function were
separately examined.
In the group subjects with corpus luteum insufficiency the menstrual cycle
lasted 26,72+-2,10 days where it lasted 28,90+-2,50 days (p<0,01) in the
controls. Follicular phase was longer (16,40+-2,13) in women with corpus
luteum insufficiency than in control subjects (14,90+-1,70) (p<0,01),
whereas luteal phase was shorter (10,32+-1,92 days) in the former group
than in the latter one (14,00+-1,92) (p<0,01).
No difference was found in either the duration (p>0,01) or the level of
basal temperature increase (p>0,01) between these two groups.
Slight hyperprolactinemia was recorded in 14,28% of the patients in the
group of women with corpus luteum insufficiency.
On the day seven of the luteal phase the progesterone level was
significantly (p<0,01) lower (36,8+-8,9) in women with corpus luteum
insufficiency than in the controls. No correlation was found in the
progesterone level between single and pairblood sample (R=0,29,p>0,01) on
the same day of luteal phase. This speaks in favour of the fact of
pulsating progesterone excretion. The progesterone level significantly
oscillates (p<0,01) in two-day intervals during the luteal phase. Therefore
we would recommend the determination of progesterone level in a pair blood
sample always on the day seven of the luteal phase. All the subjects with
corpus luteum insufficiency showed the progesterone level in the pair blood
sample below 45,54 nmol/l at the 99% confidence level.
The estradiol level in women with corpus luteum insufficiency was
0,54+-0,11 nmol/l on the day seven of the luteal phase and it was not
significantly different from that in the controls (p<0,01).A comparison
between estradiol level in a single blood sample to that in a pair sample
showed high correlation (R=0,95,p<0,01) on the day seven of the luteal
phase which proves the fact that estradiol excretion is not pulsating.A
two-day intervals during the luteal phase estradiol level significantly
declines (p<0,01) so that is recomanded always to control the estradiol
level in a single blood sample on the day seven of the luteal phase.
The ratio progesterone to estradiol was 72,8+-9,2 in the group of women
with corpus luteum insufficiency on the seventh day of luteal phase which
was significantly lower than in the controls (146,9+-26,2,p<0,01).This
progesterone to estradiol ratio minimum fluctuations during luteal phase in
both groups (p>0,01).On the day seven of the luteal phase, the value of
this ratio below 96,5 is indicative of the corpus luteum insufficiency at a
99% confidence level.
Ultrasonic measured endometrium thickness in the subjects with corpus
luteum insufficiency was 0,66+-0,14 cm and significantly lower than in the
controls (1,02+-0,14,p<0,01) on the day nine of the luteal phase.On the
same day the ultrasonic mesurement of the endometrium volume was 1,07+-0,21
cm3 in the former group which is significantly lower than in the latter
group (1,51+-0,21,p<0,01)
An ultrasonic characterisation of endometrium tissue in the women with
corpus luteum insufficiency showed the level of the most frequent shadow
(on grey scale from 1 to 64) of 17,00+-2,03 on the day nine of the luteal
phase.This was significantly different from this value in the control group
(26,47+-4,03,p<0,01).On the same day and in the same group the ratio of the
number of pixels in the most frequent endometrium shadow to the number of
pixels of the entire endometrium surface area was 4,37+-0,62 which was
significantly higher than in the controls (2,46+-0,43,p<0,01).
Hystological dating of endometrium showed a developmental lag of 3,1+-1,4
days in the women with corpus luteum insufficiency, that is the endometrium
corresponded to the day 5,9+-1,4 of the luteal phase.With respect to the
controls this difference was highly statistically significant (p<0,01).
The correlation between progesterone level in a pair blood sample on the
day seven of the luteal phase and the hystological endometrium dating on
the day nine of luteal phase (R=-0,81,p<0,01) was highly statistically
significant in women with corpus luteum insufficiency.
On the same day of the luteal phase in the same group the estradiol level
was negatively correlated with the hystological dating of endometrium on
the day nine of the luteal phase (R=-0,64,p<0,01).
The correlation between progesterone to estradiol ratio on the day seven of
corpus luteum phase and hystological dating on the day nine was also proved
in the group of subjects with corpus luteum insufficiency (R=-0,62,p<0,01).
The correlation between hystological dating of endometrium and its
thickness was also statistically significant in the group with the corpus
luteum insufficiency (R=0,71,p<0,01) as well as it was between hystological
dating and the volume of the endometrium (R=0,79,p<0,01).
The same group showed the correlation between the progesterone level in the
pair blood sample on the day seven of the luteal phase and endometrium
thickness (R=0,79,p<0,01) and volume (R=0,90,p<0,01).
However, the correlation between estradiol level on the day seven of the
luteal phase and endometrium thickness (R=-0,55,p<0,01) and volume
(R=-0,57,p<0,01) was negative in corpus luteum insufficiency group.
The group of women with the corpus luteum insufficiency showed a
significant correlation between the progesterone to estradiol level on the
day seven of luteal phase and the thickness (R=0,80,p<0,01) and volume of
the endometrium (R=0,79,p<0,01).
A significant correlation between hystological dating of the endometrium
and the level of the most frequent shadow in the entire endometrium surface
area was recorded in the subjects with corpus luteum insufficiency on the
day nine of the luteal phase (R=0,42,p<0,01).The same group showed similar
correlation between hystological datind of endometrium and the ratio of the
number of pixels in the most frequent shadow to the number of pixels of the
entire endometrium surface area (R=0,69,p<0,01).
Significant correlation between progesterone level in a pair blood sample
on the day seven of the luteal phase and the level of the most frequent
shadow of the endometrium surface area was also proved (R=0,68,p<0,01).In
the group of subjects with corpus luteum insufficiency the progesterone
level in a pair blood sample is in correlation with the ratio of the number
of pixels in the most frequent shadow to the number of pixels of entire
surface area of endometrium (R=-0,82,p<0,01) on the same day of the luteal
phase.
The correlation between estradiol level and the level of the most frequent
shadow of endometrium was negative (R=-0,40,p<0,05) on the seventh day of
luteal phase in women with corpus luteum insufficiency.On the same day of
luteal phase the same group subjects showed statistically significant
correlation between estradiol level and the ratio of the number of pixels
in the most frequent shadow to the number of pixels of the entire surface
area of endometrium (R=0,54,p<0,01).
On the day seven of luteal phase the group of women with corpus luteum
insufficiency also showed significant correlation between progesterone to
estradiol ratio and the level of the most frequent shadow of endometrium
(R=0,55,p<0,01).The correlation between progesterone to estradiol ratio and
the ratio of the number of pixels in the most frequent shadow of
endometrium to the number of pixels of the entire surface area of
endometrium was even more significant but negative (R=-0,69,p<0,01).
Keywords: CORPUS LUTEUM, PROGESTERONE, ESTRADIOL, ENDOMETRIAL BIOPSY, ULTRASOUND, CORPUS LUTEUM INSUFFICIENCY, INFERTILITY
Title: PREGNANCY AND DELIVERY IN BREACH PRESENTATION
Title: EPH-GESTOSIS AND TWIN PREGNANCIES
Title: BLEEDINGS IN EARLY PREGNANCY
Title: PREGNANCY AND DELIVERY OF LOW BIRTH NEWBORNS
Title: INFLUENCE OF ANTENATAL CARE ON EPH GESTOSIS
Title: PROGRAMMED INDUCTIONS OF DELIVERIES AT THE DEPARTMENT OF
GYNECOLOGY AND OBSTETRICS OF THE CLINICAL HOSPITAL SPLIT
Institution: DEPARTMENT OF OBSTETRICS AND GYNECOLOGY KARL FRANZENS UNIVERSITAT OF GRAZ
Year: 1994
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