Summary: The aim of the present investigation is to
determineetiophatogenic factors influencing the frequency of
macrosomicinfats born in the Šibenik area.Unusually high rates between
15and 20%,higher than anywhere in the world,have been recorded fornewborns
of pregnancy and delivery will be followed up.Eachmacrosomic infant will be
assessed for various giochemicalparameters.Ophthalmological
examination,including the fundus,willbe perfomed in the first three days of
life.Neurologic assessmentduring the first five years of life will include
psychomotorskills and growth.Psychological evaluation will compromise
thedegreemental development beginning from the first month oflife.The
obtained results will be compared with those of thecontrol group.
Research goals: The aim of the proposed research is to examine
etiophatogenic factors influencing the birth of a macrosomic
infant(weighing ň4000 g).The factors to be examined include parental
birthweights,maternal pregravid weight of her wight during the first 12
weeks of pregnancy,paternal weight at conception,maternal history of
smoking during pregnancy,maternal age,parity and weight gain during
pregnancy,impaired glucose tolerance,socioeconomic status,duration of
pregnancy,type of labour,dystocia and the mode of accomplishing delivery.It
is to be expected that higher parental birthweigts,higer maternal weight
before pregnancy or during the first 12 weeks of pregnancy,higher paternal
weight at conception, advanced maternal age,greater parity,higher weight
gain during pregnancy impaired glucose tolerance,better socioeconomic
status and postterm pregnancy will be associated with macrosomia.Induced
labour,operative delivery and dystocia are expeced to be found in
macrosomic infants more frequently.More asphyxiated newborns are higher
values of erythrocytes from umbilical blood samplings are supposed to be
found in the macrosomic group.No other differences in early neonatal
outcome are likely to be predicted.Opthalmological evalution is supposed to
reveal no differences between the macrosomic and control groups.Differences
to be expected include the mental,motor and emotional develompent of
macrosomic infants.The development quotient and subsequently the
intelligence quotient will contribute to an early detection of possible
differances in the mental development of macrosomic and control infants.