SVIBOR - Project code: 3-01-488

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-488

CLINICAL AND LABORATORY FEATURES OF BACTEREMIA AND SEPSIS

Main researcher: ŠKERK, VIŠNJA (171634)

Assistants

BOBINAC, EMIL (114945)
GNJIDIĆ, ZOJA (200151)
BAŠNEC, ANICA (193686)
RAVLIĆ, ŽELJKO (196184)
BORAS, ARIJANA (178952)

Type of research: applied
Duration from: 06/01/91. to 12/31/93.

Papers on project (total): 15
Papers on project quoted in Current Contents: 1

Institution name: Bolnica "Dr. Fran Mihaljević", Zagreb (143)

Communication: Phone: 385 (0)1 4557-222; Fax: 385 (0)1 425-907

Summary: The incidence, epidemiological, clinical and laboratory aspects of bacteremia and sepsis are analysed in patients admitted to University Hospital of Infectious Disease "Dr. Fran Mihaljević", Zagreb. The difference in incidence of particular pathogens of bacteremia, their sensitivity and changes in sensitivity to the most frequent administered antibiotics, and changes in incidence of multiploresistant species are reviewed. Possible differences in efficacy of prompt (always empirical) and delayed therapy in the treatment of patients with divers bacteremia, and the influence of prompt therapy to development of septic shock are studied, too. Results of this contininued research will be useful in making an approach of initial empirical antimicrobial therapy and also in making a decision is there has to be administered a prompt therapy of we can wait for the first results of microbiological testings at specific patients with sepsis or suspected bacteremia.

Keywords: Bacteremia, Sepsis, Septic shock, Therapy

Research goals: 1. To determine eventual difference in efficacy of prompt and delayed antimicrobial treatment in patients with all kinds of bacteremia. 2. To determine eventual influence of prompt antimicrobial treatment to development of septic shock. 3. To determine antimicrobial sensitivity of particular pathogen of bacteremia to the most frequent administered antimicrobial drug, to study eventual changes of frequency of organisms resistant to some antimicrobial drugs and changes of frequency of multiploresistant organisms. Results of this continued research will be useful in making an approach to initial empirical antimicrobial therapy and also in making a decision is there has to be administered a prompt therapy or we can wait for the first results of microbiological testing at specific patients with sepsis or suspected bacteremia.

Other information about the project.


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