- Type of paper
: Paper in journal
Title: The QT interval in Q wave and non-Q wave acute myocardial
infarction
- Authors:
- Mavrić, Žarko (142340)
- Zaputović, Luka (133542)
- Matana, Ante (69363)
- Plazonić, Željko
Journal: Croatian Medical Journal
Number: 4
ISSN: 0353-9504
Volume: 34
Year: 1993
Pages: from 314 to 318
Number of references: 20
Language: engleski
Summary: The aim of the study was to analyze the QT interval in Q
wave andnon-Q wave acute myocardial infarction (AMI). A total of
605patients with first AMI was divided into 2 groups: patients withQ wave
AMI (QAMI, N=565); patients with non-Q AMI (NQAMI, N=40).In the NQAMI
compared to the QAMI group the QTc (QT correctedaccording to Bazett's
formula) was longer in the acute stage ofAMI (0.478 vs 0.447 sec, p<0.001),
but not during the 3. week ofillness. Except for larger enzymatically
estimated AMI size inthe QAMI group, no differences between groups
regarding othervariables were found.
Keywords: myocardial infarction, QT interval, Q wave infarction, non-Q wave infarction
- Type of paper
: Paper in journal
Title: Atrial fibrillation in acute inferior myocardial
infarction: influence of right ventricular involvement
- Authors:
- Matana, Ante (69363)
- Mavrić, Žarko (142340)
- Zaputović, Luka (133542)
Journal: Medicina
Number: 1
ISSN: 0025-7729
Volume: 29
Year: 1993
Pages: from 13 to 16
Number of references: 11
Language: engleski
Summary: The aim of the study was to analyze the influence of
rightventricular infarction (RVI) on the incidence of atrialfibrillation
(AF) in patients with inferior wall acute myocardialinfarction (AMI). A
total of 225 patients with inferior AMI wasdivided into 2 groups: group I -
isolated inferior AMI (N=167);group II - inferior AMI and RVI (N=58). The
incidence of AF wassignificantly higher in group II than in group I (24% vs
8%).Patients with RVI and AF showed greater propensity to
spontaneousconversion to sinus rhythm than did patients with
isolatedinferior AMI and AF (43% vs 0).
Keywords: acute myocardial infarction, atrial fibrillation, right ventricular infarction
- Type of paper
: Paper in journal
Title: Comparison of the effects of two protocols of thrombolytic
therapy in patients with acute myocardial infarction
- Authors:
- Zaputović, Luka (133542)
- Mavrić, Žarko (142340)
- Marinović, Đuro
- Rupčić, Ana
- Roje, Josip
Journal: Medicina
Number: 1
ISSN: 0025-7729
Volume: 28
Year: 1992
Pages: from 54 to 58
Number of references: 25
Language: hrvatski
Summary: By retrospective analysis the effects of two protocols
ofthrombolytic therapy in patients with acute myocardial infarctionwere
compared. In the first group of 54 patients reperfusion wasachieved in 76%,
but with high reocclusion rate of 20%. In 190patients treated according to
the second protocol, reperfusionoccurred in 73%. Although there was no
difference in thereperfusion rate, a higher incidence of non-Q infarction
andlower reocclusion rate (10%) were registered in the secondprotocol.
Keywords: acute myocardial infarction, thrombolytic therapy
- Type of paper
: Summary in proceedings
Title: Acute myocardial infarction in the elderly: clinical
course and predictors of mortality
- Authors:
- Mavrić, Žarko (142340)
- Zaputović, Luka (133542)
- Matana, Ante (69363)
- Editors
- Čikeš, Ivo
Proceedings title: Knjiga sažetaka
Language: hrvatski
Place: Opatija
Year: 1993
Pages: from 16 to 16
Meeting: 1. kongres Hrvatskoga kardiološkog društva
Held: from 04/22/93 to 04/24/93
Summary: 902 patients with acute myocardial infarction (AMI) were
devidedinto age groups: <=70 years (group I, N=651) and >70 years (groupII,
N=251). Group II: more women, a higher incidence of leftventricular
dysfunction, arrhythmias, postinfarction angina,non-Q AMI, a higher
mortality rate. Multivariate mortalitypredictors: serum lactate (p<0.001),
bundle branch block(p<0.01), serum urea (p<0.01), previous AMI
(p<0.01),postinfarction angina (p<0.05) in group I, and serum
lactate(p<0.001), bundle branch block (p<0.001), maximal serum LDH(p<0.01)
in group II.
Keywords: acute myocardial infarction, elderly, old age, prognosis
- Type of paper
: Summary in proceedings
Title: The clinical importance of the right ventricular
involvement in patients with acute inferior wall myocardial infarction
- Authors:
- Bradić, Nikola
- Štimac, Davor
- Zaputović, Luka (133542)
- Mavrić, Žarko (142340)
- Editors
- Čikeš, Ivo
Proceedings title: Knjiga sažetaka
Language: hrvatski
Place: Opatija
Year: 1993
Pages: from 28 to 28
Meeting: 1. kongres Hrvatskoga kardiološkog društva
Held: from 04/22/93 to 04/24/93
Summary: Patients with isolated inferior wall acute myocardial
infarction(group I, N=500) and patients with right ventricular
infarction(group II, N=123) were analyzed. Group II evidenced
higherincidence of hypotension (21 vs 3%), systemic venous stasis (24vs
4%), pulmonary stasis (34 vs 24%), atrial fibrillation (27 vs16%), AV
conduction disturbances (20 vs 7%), cardiogenic shock(15 vs 3%), higher
mortality rate (15 vs 7%) and serum CK (1315vs 1125 IJ/L). Group II
patients were more often treated withplasma expanders (20 vs 2%), inotropic
agents (29 vs 7%),temporary pacing (15 vs 3%).
Keywords: acute myocardial infarction, right ventricular myocardial infarction
- Type of paper
: Summary in proceedings
Title: Central venous canulation guided by ultrasound - the
method of choice in patients with hemorrhagic diathesis
- Authors:
- Šustić, Alan
- Mavrić, Žarko (142340)
- Editors
- Čikeš, Ivo
Proceedings title: Knjiga sažetaka
Language: hrvatski
Place: Opatija
Year: 1993
Pages: from 175 to 175
Meeting: 1. kongres Hrvatskoga kardiološkog društva
Held: from 04/22/93 to 04/24/93
Summary: The authors presented their own experience
withultrasonographically guided central venous canulation of theinternal
jugular vein in 23 patients. In 13 patients indicationfor this technique
was a marked hemorrhagic diathesis.Considering the high rate of successful
canulation (91% in thefirst attempt) with no complications, the authors
believe thatan ultrasonographically guided central venous canulation is
amethod of choice in patients with hemorrhagic diathesis, e.g.,after
thrombolytic therapy in patients with acute myocardialinfarction.
Keywords: central venous canulation, ultrasound, hemorrhagic diathesis, thrombolytic therapy
- Type of paper
: Summary in proceedings
Title: Comparative analysis of the effects of different protocols
of thrombolytic therapy with streptokinase in patients with acute
myocardial infarction
- Authors:
- Zaputović, Luka (133542)
- Mavrić, Žarko (142340)
- Marinović, Đuro
- Matana, Ante (69363)
- Rupčić, Ana
- Roje, Josip
- Editors
- Čikeš, Ivo
Proceedings title: Knjiga sažetaka
Language: hrvatski
Place: Opatija
Year: 1993
Pages: from 27 to 27
Meeting: 1. kongres Hrvatskoga kardiološkog društva
Held: from 04/22/93 to 04/24/93
Summary: We analyzed the effects of three protocols of
thrombolytictherapy with streptokinase in patients with acute
myocardialinfarction, which we have been using since 1984. 65 patients
weretreated according to the first, 180 to the second, and 110 to thethird
protocol. In the first group reperfusion was achieved in71%, in the second
in 71%, and in the third in 72% of cases. Thereocclusion rate in the first
protocol was 17%, but in the secondand the third protocol it was reduced to
6% and 5%, respectively.
Keywords: thrombolytic therapy, streptokinase, acute myocardial infarction
- Type of paper
: Summary in proceedings
Title: Antecedent angina pectoris and the short-term outcome
after thrombolytic therapy for acute myocardial infarction
- Authors:
- Mavrić, Žarko (142340)
- Bradić, Nikola
- Matana, Ante (69363)
- Zaputović, Luka (133542)
- Editors
- Attila, Naszlady
Proceedings title: Cardiologia Hungarica, Suppl. 3
Language: engleski
Place: Budapest, Hungary
Year: 1995
ISBN/ISSN: 0133-5596
Pages: from 26 to 26
Meeting: 3rd Alpe-Adria Cardiology Meeting
Held: from 05/17/95 to 05/20/95
Summary: Results of previous studies have noted an association
between antecedent angina pectoris (AP) and the effects of thrombolytic
therapy for acute myocardial infarction (AMI). Nevertheless, the reported
results are not unanimous. A total of 383 consecutive patients with AMI
eligible for thrombolytic treatment were included in the study. One hundred
seventy-seven (46%) patients gave history of chronic AP (>1 month) before
AMI. Patients with AP had a higher incidence of previous myocardial
infarction (27% vs 4%, p<0.001), and recurrent ischemia (19% vs 7%,
p<0.001); the incidence of non-Q AMI was also higher, but with borderline
statistical significance (14% vs 8%, p=0.05). Successful reperfusion was
achieved in 66% of patients with antecedent AP, and in 69% of patients
without AP (p=0.66), and the reocclusion rate was the same in both groups
(7%). Multivariate analysis confirmed the independent association of
antecedent AP with previous infarction (p<0.001), recurrent ischemia
(p<0.001), and the incidence of non-Q AMI (p=0.034). All patients were
further divided into 3 groups regarding the effects of thrombolytic
therapy: successful reperfusion (group 1), no reperfusion (group 2),
reperfusion followed by reocclusion (group 3), and subdivided with respect
to the presence or absence of antecedent AP (groups 1a, 2a, 3a, and 1b, 2b,
3b respectively). The incidence of previous infarction was higher in all
groups with antecedent AP (groups 1a, 2a, 3a). The incidence of recurrent
ischemia was higher in groups 1a and 2a compared to 1b and 2b,
respectively. In the group of patients with reocclusion the rate of
recurrent ischemia was very high, but with no difference in regard to
antecedent AP. Furthermore, patients in groups 1a and 2a more frequently
presented with a non-Q AMI than patients in groups 1b and 2b. The
in-hospital course of patients without reperfusion or with reocclusion was
more complicated, with higher incidence of left ventricular dysfunction,
rhythm disturbances, and higher mortality rate, but there were no
differences regarding the presence or absence of preceding AP. It is
concluded that antecedent AP is an independent predictor neither of the
success of thrombolytic therapy, nor the incidence of major complications
in patients receiving thrombolysis for AMI.
Keywords: Thrombolysis, acute myocardial infarction, prognosis
- Type of paper
: Summary in proceedings
Title: Acute myocardial infarction following hornet sting - a
case report
- Authors:
- Bradić, Nikola
- Mavrić, Žarko (142340)
- Zaputović, Luka (133542)
- Matana, Ante (69363)
- Editors
- Attila, Naszlady
Proceedings title: Cardiologia Hungarica, Suppl. 3
Language: engleski
Place: Budapest, Hungary
Year: 1995
ISBN/ISSN: 0133-5596
Pages: from 6 to 6
Meeting: 3rd Alpe-Adria Cardiology Meeting
Held: from 05/17/95 to 05/20/95
Summary: Only few studies heave reported on cases of acute
myocardial infarction (AMI) after a wasp sting, and we found only one
following a hornet sting.
T.S., a 52 years-old man, with antecedent untreated hypertension (blood
pressure values up to 230/140 mmHg) and diabetes, but without confirmed
coronary disease and without data on previous hymenoptera stings, was stung
in the neck by a hornet while walking in the forest. Within the next few
minutes, the patient experienced an overall weakness, dizziness, shortness
of breath and retrosternal pain. After emergency assistance, the patient's
condition improved, but chest pain persisted until arrival to hospital
three hours later. The first in-hospital ECG showed inferior AMI and right
bundle branch block. On examination no generalized allergic skin reactions
were observed, except erythematous papule on the sting location. Changes
in CK and LDH values were characteristic for AMI, with a peak CK value of
610 IU/L (normal < 130 IU/L) and LDH peak value of 645 IU/L (normal < 276
IU/L). Blood pressure on arrival was 130/80 mmHg, relatively low for the
patient's constantly high levels. The blood count showed no significant
changes.
The possible mechanisms of AMI occurrence after a hornet sting may be
coronary spasm or sudden fall of blood pressure caused by an allergic
reaction and/or direct hemodynamic effects of venom constituents.
Keywords: Acute myocardial infarction, hornet sting
- Type of paper
: Summary in proceedings
Title: Relationship between QT dispersion and incidence of
serious ventricular arrhythmias in patients with acute myocardial
infarction
- Authors:
- Zaputović, Luka (133542)
- Mavrić, Žarko (142340)
- Zaninović, Tea
- Matana, Ante (69363)
- Bradić, Nikola
- Editors
- Attila, Naszlady
Proceedings title: Cardiologia Hungarica, Suppl. 3
Language: engleski
Place: Budapest, Hungary
Year: 1995
ISBN/ISSN: 0133-5596
Pages: from 45 to 45
Meeting: 3rd Alpe-Adria Cardiology Meeting
Held: from 05/17/95 to 05/20/95
Summary: There is much controversy about the influence of QT
dispersion on the incidence of ventricular tachycardia or fibrillation
(VT/VF) in patients with acute myocardial infarction. The QT, QTc, QRS and
JT dispersion (QTd, QTcd, QRSd, JTd) between two groups of patients with
acute myocardial infarction were compared: 33 patients with early VT/VF
(Group 1) and 40 patients without such arrhythmias (Group 2). QTd, QTcd,
QRSd and JTd were calculated from the admission and predischarge ECG,
expressed as the difference between maximum and minimum QT, QTc, QRS and JT
interval duration in 12 leads. The coefficient of variability for each
variable was also calculated (KQTd, KQTcd, KQRSd, KJTd). Groups did not
differ significantly in age, incidence of previous infarction, Killip
class, electrolyte status (K, Ca, Mg), infarct location, expected and final
ECG infarct size, frequency of antiarrhythmic drug administration; i.e. in
variables that could influence the VT/VF occurrence. Only higher frequency
of thrombolytic treatment was noticed in Group 1 (61% vs 10%, p<0.001). On
admission ECG patients with VT/VF had significantly greater QTd (80+-23 vs
45+-25 ms, p=0.013), QTcd (91+-27 vs 58+-36 ms, p=0.042) and JTd (76+-22 vs
45+-19 ms, p=0.016). KQTd was also significantly higher (6.72+-1.88 vs
4.47+-2.23 %, p=0.046). Although similar differences of QTd (64+-27 vs
45+-10 ms), QTcd (75+-30 vs 48+-12 ms), JTd (61+-24 vs 45+-25 ms) and KQTd
(6.04+-2.59 vs 5.50+-0.43 %) existed on predischarge ECG, these differences
were not significant. The results of this study indicate that QT dispersion
dynamically varies during the illness, and that measurements of QT
dispersion could be helpful in predicting serious ventricular arrhythmias.
Keywords: Ventricular tachycardia, fibrillation, acute myocardial infarction
- Type of paper
: Summary in proceedings
Title: Effects of preceding angina pectoris on short-term outcome
of patients with acute myocardial infarction
- Authors:
- Mavrić, Žarko (142340)
- Bradić, Nikola
- Zaputović, Luka (133542)
- Matana, Ante (69363)
- Editors
- Attila, Naszlady
Proceedings title: Cardiologia Hungarica, Suppl. 3
Language: engleski
Place: Budapest, Hungary
Year: 1995
ISBN/ISSN: 0133-5596
Pages: from 26 to 26
Meeting: 3rd Alpe-Adria Cardiology Meeting
Held: from 05/17/95 to 05/20/95
Summary: Several studies reporting on the significance and
prognostic importance of antecedent angina pectoris (AP) in patients with
acute myocardial infarction (AMI) gave opposing results. The aim of this
study was to evaluate the influence of a history of AP on short-term
outcome of patients with AMI. A total of 1370 consecutive patients admitted
for AIM were studied and divided into two groups. Four hundred seventy-two
patients (49%) had chronic AP (> 1 month) before AIM, and 698 patients had
no history of AP. Patients with AP were older (mean age 63 +- 11 vs 61 +-
11 years, p<0.001), had a higher incidence of hypertension (60% vs 51%,
p<0.001), previous myocardial infarction (37% vs 5%, p<0.001), were less
likely to be smokers (29% vs 48%, p<0.001), more often had signs of left
ventricular dysfunction (Killip class >1) on admission (33% vs 22%,
p<0.001), and presented more frequently with non-Q AMI (12% vs 7%,
p=0.002). Their in-hospital course was characterized by higher incidence of
severe left ventricular dysfunction (Killip class 3 and 4, 14% vs 7%,
p<0.001), and higher overall mortality rate (13% vs 8%, p=0.003).
Cardiogenic shock was the cause of death in 66% of patients with AP and in
42% of patients without AP who succumbed to AMI (p=0.005). Furthermore,
shock was more often a fatal complication in patients with AP than in those
without AP (fatality rate of 94% vs 76%, respectively, p=0.012). The
incidence of recurrent ischemia was also higher in patients with preceding
AP (24% vs 11%, p<0.001). There were no significant differences between two
groups of patients regarding gender, incidence of diabetes mellitus,
hyperlipoproteinemia, occurrence of rhythm disturbances (atrial
fibrillation, ventricular tachycardia, ventricular fibrillation, AV
conduction disturbances), thrombolytic treatment, and enzymatic indices of
infarct size. However, a multivariate analysis, taking into account all
variables that were significant in univariate analysis, confirmed the
independent association of antecedent AP only with age (p=0.009), history
of smoking (p=0.021), previous myocardial infarction (p=0.005), incidence
of non-Q AMI (p=0.035), and recurrent ischemia (p<0.001). It is concluded
that chronic AP preceding AMI predicts recurrent ischemia and the
development of non-Q AMI, but that it is not independently associated with
the occurrence of in-hospital complications or mortality.
Keywords: Acute myocardial infarction, angina pectoris, prognosis
- Type of paper
: Ph.D.
Title: Prognostic evaluation of patients with acute myocardial
infarction
Faculty: Medicinski fakultet Rijeka Sveučilište u Rijeci
Author: MAVRIĆ ŽARKO
Date of defense: 09/27/91
Language: hrvatski
Number of pages: 150
Summary: A total of 920 patients with acute myocardial infarction
wasdivided into 2 groups: group I - survived the hospital phase ofillness
(N=660), group II - died during hospitalization (N=90).Clinical, laboratory
and ECG variables were analyzed byunivariate and multivariate statistical
methods. Multivariatepredictors of mortality were serum lactate, urea and
LDH levels,recurrent ischemia, age >70 years, bundle branch block,
sinustachycardia. Prognostic index was computed using discriminantfunction
analysis, revealing a good sensitivity, specificity andpredictive value.
Keywords: acute myocardial infarction, prognosis, prognostic index
- Type of paper
: Ph.D.
Title: Comparison of the effects of different protocols of
thrombolytic therapy in patients with acute myocardial infarction
Faculty: Medicinski fakultet Rijeka Sveučilište u Rijeci
Author: ZAPUTOVIĆ LUKA
Date of defense: 12/17/93
Language: hrvatski
Number of pages: 179
Summary: The effects of three protocols of thrombolytic therapy
inpatients with acute myocardial infarction were compared byretrospective
analysis. In 65 patients treated with the firstprotocol reperfusion
occurred in 71%, but with high reocclusionrate of 17%. Although the
incidence of reperfusion in 180patients treated with the second, and 110
patients treated withthe third protocol did not differ from those obtained
by thefirst protocol, the reocclusion rate fell to 6% and 5%,respectively.
Keywords: thrombolytic therapy, streptokinase, acute myocardial infarction
- Type of paper
: Ph.D.
Title: Right ventricular myocardial infarction - clinical
characteristics and prognostic significance
Faculty: Medicinski fakultet Rijeka Sveučilište u Rijeci
Author: MATANA ANTE
Language: hrvatski
Number of pages: 248
Summary: This study included 630 patients with
inferior/posterior left ventricular myocardial infarction admitted to the
Coronary Care Unit, Department of Internal Medicine, Clinical Hospital
Center Rijeka, during the period 1988-1992, and covered the time of
hospitalization and the first year following infarction.
Patients were divided into two groups. Group I (i.e., control group)
included patients with inferior/posterior left ventricular myocardial
infarction without right ventricular involvement, and group II included
those with inferior/posterior left ventricular infarction with right
ventricular involvement (RVI) diagnosed by ECG criteria. Of the studied
population 140 (22.2%) patients had RVI.
The in-hospital course of patients with RVI was characterized by more
complications, therapeutic particularities and a higher mortality
(complications: 69.3% of patients with vs 52.6% without RVI, p <0.001;
cardiogenic shock: 10.7% with vs 2.4% without RVI, p <0.001; prolonged
hypotension: 5.7% with vs 1.2% without RVI, p = 0.004; electromechanical
dissociation: 7.1% with vs 2.2% without RVI, p = 0.004; Killip class II:
35.0% with vs 24.1% without RVI, p = 0.01; atrial fibrillation: 15.0% with
vs 8.0% without RVI, p = 0.013; malignant ventricular arrhythmias: 10.7%
with vs 5.1% without RVI, p = 0.016; III0 atrioventricular block: 22.9%
with vs 6.3% without RVI, p<0.001; new bundle branch block: 6.4% with vs
1.6% without RVI, p = 0.002; in-hospital mortality rate: 12.9% with vs 5.5%
without RVI, p = 0.005).
The most frequent cause of death was cardiogenic shock (44.4 %) in the
RVI group, and left ventricle rupture (37.0%) in the control group.
Patients with cardiogenic shock in both groups had a high fatality rate,
although it was lower to some extent in patients with RVI (53.3% vs 66.7%,
respectively, p = 0.49). The greatest difference was observed in patients
with a new bundle branch block: all died in the RVI group, and not one in
the group without RVI (p <0.001).
In the first post-infarction year patients that recovered from RVI had
fewer difficulties (41.8% with RVI vs 62.0% without RVI, p <0.001), and
they less frequently required re-hospitalzation (9.8% with vs 20.5% without
RVI, p = 0.007). Post-infarction angina pectoris and its unstable form were
less frequent in patients with RVI (angina in 36.9% with vs 48.3% without
RVI, p = 0.025; unstable angina in 2.5% with vs 7.8% without RVI, p =
0.037). The incidence of new myocardial infarction and heart failure was
not significantly different in patients with compared to those without RVI.
Cardiac death occurred in 3.3% of patients with RVI and in 4.3% of patients
from the control group (p = 0.62), and arrhythmias were the most frequent
cause of death (75.0% of patients who died in each group).
The independent risk factors for RVI occurrence in patients with
inferior/posterior left ventricular infarction were female sex (p = 0.028)
and the absence of pre-infarction angina pectoris (p = 0.025).
The independent predictors of in-hospital mortality in group I were
cardiogenic shock (p <0.001), malignant ventricular arrhythmias (p <0.001),
peak serum urea value (p = 0.01) and patients age (p = 0.017). In group II
the predictors were cardiogenic shock (p <0.001), new bundle branch block
(p <0.001), patients age (p <0.001) and serum lactate values (p = 0.025).
Keywords: acute myocardial infarction, right ventricle
- Type of paper
: Mentorship
Title: Comparison of the effects of different protocols of
thrombolytic therapy in patients with acute myocardial infarction
Faculty: Medicinski fakultet Rijeka Sveučilište u Rijeci
Mentor: MAVRIĆ ŽARKO
Date of defense: 12/17/93
Number of pages: 179
Author: Zaputović Luka
Degree level: Ph.D.
- Type of paper
: Mentorship
Title: Right ventricular myocardial infarction - clinical
characteristics and prognostic significance
Faculty: Medicinski fakultet Rijeka Sveučilište u Rijeci
Mentor: MAVRIĆ ŽARKO
Number of pages: 248
Author: Matana Ante
Degree level: Ph.D.
- Type of paper
: Mentorship
Title: The influence of QT interval dispersion on the incidence
of malignant ventricular arrhythmias in patients with acute myocardial
infarction
Faculty: Medicinski fakultet Rijeka Sveučilište u Rijeci
Mentor: ZAPUTOVIĆ LUKA
Author: Zaninović dr.med. Tea
Degree level: M.A.
- Type of paper
: Invited lecture
Title: Electrocardiographic and enzymatic estimation of acute
myocardial infarct size in the evaluation of the success of thrombolytic
therapy
Institution: 1. kongres Hrvatskoga kardiološkog društva, Opatija 1993.
Year: 1993