SVIBOR - Project code: 3-03-301

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

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Project code: 3-03-301


Trichinellosis: Immunology and Immunopathology of the Zoonose


Main researcher: MARINCULIĆ, ALBERT (139934)


Assistants
Type of research: basic
Duration from: 01/01/91. to 01/01/95.
Papers on project (total): 12
Papers on project quoted in Current Contents: 3
Institution name: Veterinarski fakultet, Zagreb (53)
Department/Institute: Department of Parasitology and Parasitic diseases
Address: Heinzelova 55
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)2390362
Summary: After establishing of the optimal model for a production of parasite antigens and their protein characterisation, studies will be concentrated on pecularities of human immune response against trichinellosis. In order to define the prevalence of the disease, epidemiological and seroepidemiological screening in endemic areas of Croatia will be performed. Different immunological tests (blastogenic transformation, ELISA, Western blotting and immunohistochemical methods) will be used in order to define the immune status of recently infected patients. Addingly, further effort will be also concentrated on developing suitable methods using other than excretory-secretory parasite antigens to detect antibodies in recently infected patients. in that way surface protein antigens will be also used.

Keywords: trichinellosis, humans, swine, immunology

Research goals: - establishment of the chronic trichinellosis model in humans onthe basis of immunological findings - seroprevalence of asymptomatic trichinellosis in endemicregions of Republic of Croatia -testing of suitable immunodiagnostic methods for early detectionof trichinellosis - the role of sylvatic trichinellosis in the epidemiology oftrichinellosis in humans - relationship between the immune responses of swine and humansand the pathogenesis of the disease - parasite immunomodulation during infection On the basis of performed research we are expecting basical data that wll improve the understanding of immunology and immunopathology of the disease as well as differences in the immune response among different host. Throgh the study,early detection of trichinellosis in humans by immunodiagnostic tests will be also investigated.

COOPERATION - INSTITUTIONS


  1. Name of institution: Istituto Superiore di Sanita
    Type of institution: University/Faculty
    City: RIM, ITALIJA

  2. Name of institution: Agricultural Research Service, Beltsville,United States Dept. of Agriculture, USA
    Type of cooperation: Joint publishing of scientific papers
Other information about the project.
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Last update: 10/12/95
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