SVIBOR - Project code: 3-03-471

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-03-471


Immunoprophylaxis of viral diseases in poultry


Main researcher: MAZIJA, HRVOJE (30025)



Assistants
Type of research: developmental
Duration from: 06/30/92. to 06/30/96.

Papers on project (total): 38
Papers on project quoted in Current Contents: 3
Institution name: Veterinarski fakultet, Zagreb (53)
Department/Institute: Department of poultry pathology
Address: Heinzelova 55,
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)10 2390-280
Fax: 385 (0)10 21-46-97

Summary: There will be investigated the immunogenicity for chicken of vaccine strains of viruses of infectious bronchitis (IB), Newcastle disease (ND), Infectious bursal disease (IBD) and HVT FC-126 of Marek*s disease (MD) virus, administered in form of spray of very small particles, not bigger than 7 mikrons. As a difference from classic ways of spraying, proposed procedure enables the vaccine virus to enter tracheolar canals and air sacs that enormously increase the respiratory resorptive surface. Therefore the expected achieved immunity should be higher and its appearance much earlier in comparison to any other way of administration. While in the immunoprophylaxis of IB, ND and IBD the spring of viral suspension is in commune use, but entirely different from proposed in this investigation, the use of spray of MD vaccines till now remain unsuccsessful. Newertheless it was always used the spray of bigger particles and not so small as it is here proposed. Very small particle of the vaccine virus suspension, produced by use of ultra sound nebulizer that increase the titre of the virus and special from the virus is protected to be used resuspended in sterile distilled water, are the bases of believing on success of proposed investigation.

Keywords: fattening chicken, chicken, infectious bronchitis, infectious bursal disease, Newcastle disease, Marek*s disease, vaccination, very fine spray

Research goals: The goal of the investigation is to induce the best possible specific immunoprotection against most dangerous diseases in poultry (chicken is used as a model) threaten the poultry production in Croatia. These diseases are Newcastle disease (ND), infectious bursal disease (IBD), infectious bronchitis (IB) and Marek*s disease (MD). The first three of them can be controlled by use spray of vaccine viruses, while MD is controlled by parenteral vaccination (s/c or i/m). Beside already achieved experiences about controlling ND by use of very fine particle of vaccinal virus suspension, for other three mentioned diseases there are strong indication that fine spray of less than 7 microns particle diameter can be used to stimulate high immune response. If this presumption shows justified, and there are many reasons to believe it because all mentioned diseases are transmitted as respiratory infections, the proposed mode of vaccination should unable the vaccination of day old poultry immediately after being hatched i.e. in the hatchery. It is certainly before hatched poultry is exposed to different pathogenes. In case of MD it is an entirely new and manifold better mode of immunoprotection. Vaccination of fattening chickens against MD could become a routine practice which, according to past experience of parenteral use of HVT FC-126, can bring to better results in production up to 20%.


COOPERATION - INSTITUTIONS


  1. Name of institution: Pliva, Istraživanje i razvoj, HR, 41000 Zagreb, Prilaz baruna Filipovića 89
    Type of institution: Economical/Production
    Type of cooperation: Systematic exchange of experts
    City: 10000 - Zagreb, Croatia

  2. Name of institution: Klinički bolnički centar Dubrava
    Type of institution: Non-profit
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia


OTHER ACHIEVEMENTS


  1. Name: Zlatna plaketa INOVA 1993., Salon inovacija Zagreb Nova vakcina Marekove bolesti
    Type of achievement: Other
    Authors: S. Čajavec, H. Mazija, Đ. Nemarnik, I. Režić

  2. Name: Medaille d*or Pour le proccessus. Brussels Eureka *93Nouveau vaccin contre la maladie de Marek.
    Type of achievement: Other
    Authors: S. Čajavec, H. Mazija, Đ. Nemarnik, I. Režić

  3. Name: Nagrada "Dragutin Slavoljub Penkala" za najbolju inovaciju u godini 1993. Nova vakcina Marekove bolesti
    Type of achievement: Other
    Authors: S. Čajavec, H. Mazija, Đ. Nemarnik, I. Režić

  4. Name: IV. HRVATSKI SALON INOVACIJA 1995. "VELIKA NAGRADA"
    Type of achievement: Instrumentation
    Authors: Hrvoje Mazija, Tihomir Štimac

  5. Name: INOVA 1995. I. NAGRADA SAVEZA INOVATORA GRADA ZAGREBA
    Type of achievement: Instrumentation
    Authors: Hrvoje Mazija, Tihomir Štimac

  6. Name: GOLD MEDAL INPEX XI, 1995. Pittsburgh, S.A.D.
    Type of achievement: Instrumentation
    Authors: Hrvoje Mazija, Tihomir Štimac

  7. Name: BRONZE MEDAL INPEX XI, 1995. Pittsburgh, S.A.D.
    Type of achievement: Prototypes
    Authors: Hrvoje Mazija, Tihomir Štimac

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Last update: 10/16/95
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