SVIBOR - Project code: 1-07-019

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

SVIBOR - Collecting Data on Projects in Croatia

Project code: 1-07-019


Compounds with particular properties - synthesis and structure


Main researcher: KAMENAR, BORIS (20013)


Assistants
Type of research: basic
Duration from: 01/01/91. to 12/31/93.
Papers on project (total): 282
Papers on project quoted in Current Contents: 92
Institution name: Prirodoslovno-matematički fakultet, Prirodoslovni odjeli, Zagreb (119)
Department/Institute: Laboratory of General and Inorganic Chemistry, Chemistry Departm ent, Faculty of Science, University of Zagreb
Address: Ul.kralja Zvonimira 8, 10000 Zagreb, P.P.153, Hrvatska
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (1) 442823
Fax: 385 (1) 432526
E-mail: kamenar@public.srce.hr
Summary: The project comprises synthetic and structural investigations of mercury compounds, transition metal complexes and biologically active substances. In particular, it considers the dimercuration of organomercury compounds by exchanging mercury with another atom, and the mercuration of aliphatic carboxylic and keto acids, ketones and of permercurated methane derivatives. In the connection with the broader study on coordination and stereochemistry of the transition metal complexes it includes the syntheses and structural caracterizations of molybdenum,nickel, copper, cobalt, iron and platinum group complexes with the ligands interesting in the biological systems. Such complexes can be used as models for the better understading of function and activity of biologically interesting molecules as well as of some catalytical processes. The project includes also the structural investigations of organic molecules with antibiotical,antibacterial and antiviral activity. The synthesis and structure of calcium phosphates and carboxylates important in the biomineralization processes are also studied.The stereochemical studies include also the structural investigation of the compounds with the lone electron pair at the central atom. As part of the above structural work a development of the new computing methods in the X-ray structure analysis is also included.

Keywords: mercury compounds, transition metal complexes, biologically active compounds

Research goals: Objectives of the proposed research is the synthesis and the structure determination of mercury compounds, complex compounds of transition and other metals and of biologically and pharmacologically active compounds. New numerical methods used in the structure analysis as well as software will be developed. a) Demercuration of organomercury compounds and the synthesis of the new salts of permercurated methane. Mercury compounds, their crystal structures and the crystal chemistry of mercury. b) The new transition metal complexes will be studied as possible models of biological systems as well as potential catalysts, particularly of molybdenum complexes and the trans-influence of the oxo-O ligands. The synthesis and structure determination of the new Mo-complexes with oxygen, nitrogen and sulphur as donors. The transition metals complexes, their stereochemistry and coordinating properties of specific ligands. The complexes of the platinum group elements as potential catalysts and anticancer agents. c) Structural investigations of compounds with antibiotic, antibacterial and antiviral activity (e.g macrolide antibiotics and their complexes, beta-lactams etc.). Heterocyclic compounds and their regio- and stereoselective inter- and intramolecular addition mechanisms. Pyridinium-oximes similar to Ach and nicotine and their antidotal activity. The structure of new metal complexes with macrocyclic ethers. d) The calcium phosphate carboxylates and their importance for calcification and biomineralization. e) Stereochemical role of the unshared electron pair in the structure of the acetates of the V b group elements.

COOPERATION - PROJECTS


  1. Name of project: 1-07-035 Kemija i biokemija antimikrobnih sredstava
    Name of institution: Istraživački institut Pliva
    City: 10000 - Zagreb, Croatia

  2. Name of project: 1-07-165 Strukture, svojstva i reaktivnost kemijskih sustava
    Name of institution: Institut Rudjer Bošković
    City: 10000 - Zagreb, Croatia

  3. Name of project: 1-07-333 Sinteza i stereodinamička istraživanja kiralnih i farmakološki zanimljivih spojeva
    Name of institution: Fakultet kemijske tehnologije i inženjerstva
    City: 10000 - Zagreb, Croatia

  4. Name of project: 1-07-241 Sinteza i biološko djelovanje antidota organofosfornih spojeva
    Name of institution: Zavod za organsku kemiju i biokemiju, Prirodoslovno-matematički fakultet
    City: 10000 - Zagreb, Croatia

  5. Name of project: Synthesis, enanthiomeric resolution, barriers to racemization and absolute configuration of some chiral 2,2'-bridged and 2,2',6,6'-doubly bridged biphenyls
    Name of institution: Division of Organic Chemistry, Chemical Center, University of Lund, Sweden
    City: Lund, Švedska

  6. Name of project: 1-07-179 Odnos strukture i kemijskih te bioloških svojstava molekula
    Name of institution: Institut Ruđer Bošković
    City: 10000 - Zagreb, Croatia

  7. Name of project: Structural study of (a) metalloorganic compounds of great interest for understanding catalysis mechanism of several chemical reactions; (b) model compounds of biological macromolecules such as metalloenzymes.
    Name of institution: Dipartimento di Chimica e Dipartimento di Sistemi e Informatica, Universita degli Studi di Firenze
    City: Firenze, Italija

COOPERATION - INSTITUTIONS


  1. Name of institution: Istraživački institut Pliva
    Type of institution: Economical/Production
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  2. Name of institution: Institut Rudjer Bošković
    Type of institution: State institute
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  3. Name of institution: Fakultet kemijske tehnologije
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  4. Name of institution: Zavod za organsku kemiju i biokemiju, Prirodoslovno-matematički fakultet
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  5. Name of institution: Division of Organic Chemistry, Chemical Center, University of Lund, Sweden
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Lund, Švedska

  6. Name of institution: Dipartimento di Chimica e Dipartimento di Sistemi e Informatica, Universita degli Studi di Firenze
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Firenze, Italija
Other information about the project.
MZT Croatian language SVIBOR Alphabetic list Sorted on project code Sorted on institutions Search help
Ministry of
Science and
Technology		 Croatian
language		 Svibor
homepage		 Alphabetic
list		 Sorted on
project code		 Sorted on
institutions		 Search Help
Last update: 09/20/95
Information: svibor@znanost.hr