SVIBOR - Project code: 1-07-044

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 1-07-044


Preparation and properties of novel immunomodulatory compounds


Main researcher: TOMAŠIĆ, JELKA (49776)


Assistants
Type of research: basic
Duration from: 01/01/91. to 01/01/93.
Papers on project (total): 73
Papers on project quoted in Current Contents: 13
Institution name: Imunološki zavod, Zagreb (21)
Department/Institute: Radioimmunology and chemistry
Address: Rockefellerova 10
City: 10000 - Zagreb, Croatia
Communication
Fax: 385 (041) 277-278
Fax: 385 (01) 277-278
Summary: The project comprises interdisciplinary research in the field of chemistry, biochemistry, biology and immunology. The aim of the project is: 1. The preparation of new compounds posessing immunomodulating activity, with emphasis on new derivatives of peptidoglycan monomer and new adamantyl peptides, including synthetic modifications of peptide chain as well as the syntheses of adamantyl peptides. Synthetic modifications of carbohydrate molecules and the use of serum esterases for deprotection of carbohydrates will also be investigated. 2. To test biological activity of prepared novel compounds in experimental models in vivo and in vitro, including immunomodulating, antitumor and antiviral activities. 3. The development of immunotests (immunoradiometric and enzymeimmunoassays) for detection and quantitative determination of biologicaly active compounds in biological material.

Keywords: adamantyl peptides, peptidoglycan, immunomodulators, peptides, carbohydrates, esterases, antitumor activity, antiviral activity, organic syntheses, radioimmunoassay, enzymimmunoassay, allergens

Research goals: The purpose of the proposed project has been the study ofstructure-activiy relationship, particularly the effects ofchemically well defined compounds on selected parameters ofimmune system. Such interdisciplinary oriented project comprisesstudies in different research fields and the results of thesestudies should provide new insights into the possibility ofmodulation of biological activity and immune response. 1. Native bacterial peptidoglycans are specially interestingstructures possesing marked immunomodulating properties. In thescope of the proposed project, new methods for the preparation ofcompounds containing elements of peptidoglycan structure will beinvestigated: a) modification of native peptidoglycan monomer(PGM) and b) de novo syntheses of adamantylpeptides in whichadamantyl residue will be coupled to peptidoglycan fragment. 2. The biological activity of prepared novel compounds will betested in model systems in vivo and in vitro. The effects oftested compounds will be estimated with regard to possibleantitumor and antimetstatic activity, immunomodulating propertiesand antiviral activity. 3. The preparations of appropriate immunogens by coupling haptensto proteins will be studied, followed by immunization of animalsin order to prepare specific antisera. New test systems (radio-and enzymeimmunoassays) for the detection of biologically activecompounds in biological material will be developed.

COOPERATION - PROJECTS


  1. Name of project: CI1*CT-90-0711 Syntheses of novel adamantylpeptides and glycopeptides with potential antivira and immunomodulating properties
    Name of institution: Universita degli Studi di Trieste, Istituto di Farmacologia e Farmacognosia; Dipartimento di Scienze Chimiche
    City: Trst, Italija

COOPERATION - INSTITUTIONS


  1. Name of institution: Institut "Ruđer Bošković"
    Type of institution: University/Faculty
    City: 10000 - Zagreb, Croatia

  2. Name of institution: Prirodoslovno-matematički fakultet, Kemijski odjel, Zavod za organsku kemiju i biokemiju
    Type of institution: Economical/Production
    City: 10000 - Zagreb, Croatia
Other information about the project.
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Last update: 10/18/95
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