SVIBOR - Project code: 1-07-106

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

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Project code: 1-07-106


SYNTHESIS AND PROPERTIES OF (HETERO)CYCLIC COMPOUNDS AND METALLOCENES


Main researcher: RAPIĆ, VLADIMIR (40311)


Assistants
Type of research: basic
Duration from: 01/01/91. to 12/31/95.
Papers on project (total): 66
Papers on project quoted in Current Contents: 9
Institution name: Prehrambeno-biotehnološki fakultet, Zagreb (58)
Department/Institute: Laboratory of Organic Chemistry Institute of Chemistry and Biochemistry
Address: Pierottijeva 6/VI
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)1 441 639
Fax: 385 (0)1 418 230
E-mail: VRAPI] a MAPBF.PBFRNG.HR
Summary: In this project the preparation of a series of carbocyclic and heterocyclic systems (benzodiazepines, benzimidazoles, diisoxazoles, dipyrazoles, pyrrolotropones, and other ones) by the action of suitable reagents on the various mono-,tri- and tetra-ketones is planned. Their structure and reactivity will be studied;the attention will be focussed on the photochemical conversions of diisoxazoles and on the electrochemical reactions of polysubstituted benzenes. The synthesis and resolution of atropisomeric N-aryl-1,2,3,4-tetrahydroquinolinediones and their thio analogues will be examined.The preparation and the application of the Schiff bases with coumarin as the analytical reagents will be done.In the field of metallocenes, ferrocenylfulvenes and 1,1'-ferrocenylenebisfulvenes will be synthesized, and the stereochemistry of their Diels-Alder products will be investigated;the preparation and reactivity studies of omega-ferrocenylaliphatic acids,omega-ferrocylthioaliphatic acids,and of corresponding bisacids will be undertaken.X-Ray structural analysis of some of the compounds prepared will be done.The investigations of the growth of ochratoxin A and of the biosynthesis of aflatoxines in collaboration are planned.

Keywords: Polyoxo compounds, heterocycles, carbocycles, atropisomers, Schiff bases, ferrocenes, fulvenes, X-ray analysis, spectroscopic analysis, (thia)aliphatic acids

Research goals: The planned investigations represent continuation of the works in the fields of polyoxo compounds,carbocycles,heterocycles and metallocenes,which have been undertaken for years in Laboratory of Organic Chemistry of Faculty of Food Technology and Biotechnology.The previously prepared polyoxo compounds of various structures will be converted to (fused) carbocyclic and heterocyclic systems.In the field of coumarins a series of Schiff bases will be synthesized and their stability and chelating properties investigated.The synthesis and barriers to racemization of atropisomeric N-aryl-2,4-quinolinedione derivatives and their thio analogues are to be done. The preparation of ferrocene fulvenes and the stereochemistry of their Diels-Alder adducts,and the synthesis and reactivity of omega-ferrocenylaliphatic acids and omega-ferrocylthioaliphatic acids will be investigated.In the greater part of these works the fundamental contribution to the chemistry of polyoxo compounds, carbocycles,heterocycles and metallocenes is expected.The special attention will be focussed on the stereochemistry,reaction mechanisms and X-ray studies of metallocenes and some heterocyclic compounds.This investigations are partly directed to the preparation of the compounds with potential bioactivity or with the possibility of application.

COOPERATION - INSTITUTIONS


  1. Name of institution: Zavod za organsku kemiju,Fakultet kemijskog inženjerstva i tehnologije
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  2. Name of institution: Zavod za analitičku kemiju, Prirodoslovni odjeli, Prirodoslovno-matematički fakultet
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  3. Name of institution: Zavod za organsku kemiju, Prehrambeno-tehnološki fakultet
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 31000 - Osijek, Croatia

  4. Name of institution: Laboratorij za mikrobiologiju,Prehrambeno-biotehnološki fakultet
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia
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Last update: 10/10/95
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