Type of research: basic Duration from: 01/01/91. to 12/31/93. Papers on project (total): 39
Papers on project quoted in Current Contents: 12
Institution name: Institut "Ruđer Bošković", Zagreb (98) Department/Institute: Department of Organic Chemistry and Biochemistry Address: Bijenička c. 54 City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (01) 4561-111
Phone: 385 (01) 424-784
Fax: 385 (01) 425-497
Fax: 385 (01) 425-647
Summary: Baker's yeast catalyzed stereoselective reduction of
ketones, precursors of biologically active compounds will be investigated.
Microbial lipases will be used for enantioselective hydrolysis (kinetic
resolution) of O-acyl derivatives of rac. alcohols, as are benzoxazepines,
and benzotiazepines, 7alpha,beta-O-acyl zearanoles, and other precursors of
biologically important compounds. Optimal enzyme and reaction conditions
for any substrate will be determined. Thermodynamical and structural
properties of precatalytic complexes of polymolibdate with monosaccharides
(aldoses) will be investigated. Products of isomerization and subsequent
hydrogenation are important commercial products.
Research goals: There are two main targets of this project:
a. To develop new enantioselective reactions with microbial lipases, in
particular hydrolysis in aqueous buffers, and acylations in organic
solvents. These reactions represent the key steps in chemoenzymtic
syntheses of important, biologically active compounds in the optically pure
form b. To develop new "comby-process" for contemporaneous, metal
catalyzed isomerization, i.e. C(2)-epimerization, of aldoses, and their
contemporaneous reduction in the C(2) epimeric alditol, shifting the
equilibrium completely to this products. The results of this research
will be presented in original papers published in the international
journals with strict reviewing process, and patents, where results
represent also new solution of technical problem.
COOPERATION - PROJECTS
Name of project
: JF-965 Biocatalytic Stereoselective
Transformations Name of institution: National Institutes of Health (NIH) City: Bethesda, USA
Name of project
: 2KOA6A Biokatalyse and Strukturaufklaerung von
Zuckerderivaten Name of institution: Kernforschungszentrum Julich City: Julich, Njemačka
Name of project
: COST-CA D2 Enantioselective Synthesis of
Optically Active Organic Compounds Name of institution: Lajos Kosuth University of Debrecen City: Debrecen, Mađarska Other information about the project.