SVIBOR - Papers quoted in CC - project code: 1-08-240
MINISTRY OF SCIENCE AND TECHNOLOGY
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SVIBOR - Collecting Data on Projects in Croatia
Papers quoted in Current Contents on project 1-08-240
Quoted papers: 10
Other papers: 121
Total: 131
Title: Retinoic acid can change normal differentiation of rat
egg-cylinders cultured in vitro
- Authors:
- Crnek-Kunstelj, Vesna (73986)
- Vlahović, Maja (150302)
- Škreb, Nikola (47401)
Journal: International Journal of Developmental Biology
Number: 0003
ISSN: 0124-6282
Volume: 0035
Year: 1991
Pages: from 00197 to 00202
Number of references: 55
Language: engleski
Summary: To study the effect of retinoids on early rodent
differentiation, retinoic acid (RA) was added in various concentrations to
serum-supplemented or serum-free medium of organ cultured rat embryos. RA
inhibited chondrogenesis as well as keratinization of squamous epithelium
and enhanced differentiation of columnar epithelium.
Keywords: rat embryo, organ culture, retinoic acid, differentiation
Title: The ability of the epithelium of diencephalic origin go
differentiate into cells of the ocular lens
- Authors:
- Jurić-Lekić, Gordana (111152)
- Bulić-Jakuš, Floriana (119890)
- Kablar, Boris (165584)
- Švajger, Anton (48696)
Journal: International Journal of Developmental Biology
Number: 0003
ISSN: 0124-6282
Volume: 0035
Year: 1991
Pages: from 00231 to 00237
Number of references: 38
Language: engleski
Summary: This review of lentoid differentiation from diencephalic
cells is based upon our previous results. In short, epiphyseal cells of
diencephalic origin do not transdifferentiate to lens cells as ependymal
and retinal cells do in embryo renal grafts. As our results showed, only
neural tissue differentiated in grafts of rudiments of epiphyseal gland.
Keywords: lens, lentoids, diencephalon, transdifferentiation, rat
Title: Cell type and differentiation dependet heterogeneity in
retinoblastoma protein expression in SCID mouse fetuses
- Authors:
- Szekely, L
- Jiang, W.Q.
- Bulić-Jakuš, Floriana (119890)
- Rosen, A.
- Ringertz, N.
- Klein, George
- Wiman, Klaus G.
Journal: Cell Growth and Differentiation
Number: 0003
ISSN: 1044-9523
Volume: 0003
Year: 1992
Pages: from 00149 to 00156
Number of references: 45
Language: engleski
Summary: The expression pattern of retinoblastoma protein has been
studied at the single level in mouse fetuses by immunofluorescence
staining. The nuclei of megakaryocytes, hemopietic islands, osteoblasts and
skeletal muscles were strongly stained. There was no detectable staining in
the basal cell layers of stratified syuamous epithelium, but the
differenitating layers were positive. In the retina Rb protein was also
detectable in differentiated inner ganglion layer, but not in the
mitoticaly active neuroblastic layer. We concluded that the expression of
the Rb protein is geterogenus in mammalian embryo depending on the degree
of differentiation.
Keywords: retinoblastoma protein, expression, fetus, mouse
Title: Differentiation and growth of rat egg cylinders cultured
in vitro in a serum-free and protein-free medium
- Authors:
- Škreb, Nikola (47401)
- Bulić-Jakuš, Floriana (119890)
- Crnek-Kunstelj, Vesna (73986)
- Stipić, Jasna
- Vlahović, Maja (150302)
Journal: International Journal of Developmental Biology
ISSN: 0124-6282
Volume: 0037
Year: 1993
Pages: from 00151 to 00154
Number of references: 34
Language: engleski
Summary: Modified organ cultures of rat egg cylinders were grown for
two weeks in Eagle's minimal essential medium (MEM) without serum. The
purpose of the experiment was to determine whether terminal tissue
differentiation is modified by various added factors. Bovine serum albumin
and human transferrin alone stimulated the formation of lentoids, a
relatively rare tissue. Retinoic acid inhibited cartilage formation and
stimulated the differentiation of cylindrical epithelium. Neural growth
factor inhibited the growth of explants. DNA demethylation agens 5
azacytidine impeded the survival of explants. One can conclude that these
factors influenced the growth and differentiation of the early rat embryous
cultured in chemically defined medium.
Keywords: rat embryo, egg cylinder, serum-free medium, in vitro culture
Title: Protein parameters of differential gene activation during
development and tumorogenesis
- Authors:
- Šerman, Draško (46534)
- Altarac, Silvio (140525)
- Krsnik-Rasol, Marijana (23970)
- Vlahović, Maja (150302)
- Solter, Davor
- Krušić, Josip (24155)
Journal: International Journal of Developmental Biology
Number: 0003
ISSN: 0124-6282
Volume: 0035
Year: 1991
Pages: from 00279 to 00288
Number of references: 24
Language: engleski
Summary: Various models of normal and abnormal developmental systems
were adressed to get an insight into molecular parameters of cell
differentiation at the level of protein gene products. Electrophoretic
analysis of heterogeneous protein mixtures permitted qualitative analysis
of developing systems, particulary during organogenesis in mammals, as well
as of neoplastic growth in the animal and plant kingdoms. From our earlier
findings indicating that the definite protein patterns characteristic of
adult organs are aquired long after the adult morphological and
histological characteristics of these tissues have developed, it has been
repeatedly proven that quantitative changes in whole proteins is not a
dependable indicator if cell differentiation.
Keywords: cell differentiation, protein gene products, crown-gall tumor, interferon, human cervical cancer
Title: Immunoflourescence detection of the retinoblastoma protein
in mouse fetuses
- Authors:
- Szekely, L
- Jiang, W.Q.
- Bulić-Jakuš, Floriana (119890)
- Rosen, A.
- Ringertz, N.
- Klein, George
- Wiman, Klaus G.
Journal: J.Cell Bioch.
Year: 1992
Pages: from 00148 to 00148
Language: engleski
Summary: The expression of Rb protein in SCID mouse embryos was
studied at the single cell level by immunofluorescence. The difference in
expression of Rb protein, dependent of the cell type and the degree of
differentiation was discovered. Eg. Rb was present in differentiated
squamous epithelial cells, but it was absent from the basal cell layers.
The highest level of expression was found in megakaryocytis, hemopoetic
islands and sceletal muscle.
Keywords: Rb protein, SCID miš, zametak, diferencijacija
Title: Targeted changes of embryonal cell differentiation in a
serum-free model system
- Authors:
- Bulić-Jakuš, Floriana (119890)
- Crnek-Kunstelj, Vesna (73986)
- Vlahović, Maja (150302)
- Jurić-Lekić, Gordana (111152)
Journal: Cell Biol. Int.
ISSN: 1065-6995
Year: 1994
Pages: from 00088 to 00088
Language: engleski
Summary: Targeted changes of mammalian embryonal cell
differentiation can be obtained in a serum-free model system. Transferrin,
albumine and retinoic acid act as specific or unspecific permisive signals
for differentiation (eg. transferrin-lentoid, albumine and
transferrin-neuroblasts, RA-cylindrical epithelium).
Keywords: mammalian embryo, differentiation, serum-free medium, perimsive factor
Title: p185neu is Expressed in Yolk Sac During Rat
Postimplantation Development
- Authors:
- Knežević, Vladimir (156663)
- Spaventi, Radan
- Poljak, Ljiljana
- Slade, Neda
- Švajger, Anton (48696)
- Pavelić, Krešimir
Journal: Journal of anatomy
Number: 1
ISSN: 0021-8782
Volume: 185
Year: 1994
Pages: from 181 to 187
Number of references: 18
Language: engleski
Summary: We have shown that the neu oncogene product (p185neu) is
not present in the rat embryo before organogenesis. However, coincident
with the onset of organogenesis, p185neu was detected in neural and
connective tissue as well as in the secretory epithelium as was described
by Kokai and coworkers (Kokai, et al., 1987). In addition, p185neu is also
expressed in the rat visceral yolk sac (VYS) endodermal cells but in the
mesenchymal and mesothelial layers of the same structure nor in the amnion.
The first detectable sign of p185neu ecpression in VYS was found at the
11th day of gestation and the levels of protein increased towards the end
of pregnancy. In the yolk sac carcinoma (YSC), which is considered to be
the malignant counterpart of the rat yolk sac, p185neu was observed only
within columnar epithelial cells (the visceral component of the only within
columnar epithelial cells (the wisceral component of the neoplasm) while
parietal endoderm-like cells were devoid of detectable protein. From the
9th day of pregnancy up to delivery some of the trophoblastic giant cells
also showed a faint to moderate immunoreactivity. Results are presented
which would indicate a possible role of p185neu in rat embryogenesis.
Keywords: rat, embryo, p185neu oncogene
Title: Expression of TGF1-betas and their receptors during
implantation and organogenesis of the mouse embryo
- Authors:
- Bernard, A.J. Roelen
- Herbert, Y. Lin
- Knežević, Vladimir (156663)
- Freund, Eric
- Mummery, Christine L.
Journal: Development Biology
Number: 2
ISSN: 0012-1606
Volume: 166
Year: 1994
Pages: from 716 to 728
Number of references: 61
Language: engleski
Summary: The spatial and temporal expression of the TGF-beta
receptors type III, type II, and two types I(ALK-5 and Tsk 7L) and their
ligands TGF-beta1 and TGF-beta2 in postimplantation mouse development were
examined using RT-PCR, in situ hybridization and immunohistochemistry. With
RT-PCR, expression of the signallin TGF-beta receptors (type II and ALK-5)
was shown to be absent in isolated germ layers of 6.0-7.5 day p.c. embryos,
whereas the type III receptor and Tsk 7L were differentially expressed at
these stages. In contrast, all TGF-beta receptor types were expressed at
these stages in the pregnant uterus and decidua. TGF-beta1 and TGF-beta2
transcripts were detected before gastrulation at 6.5 day p.c. only in the
visceral embryonic endoderm, whereas during gastrulation, at 7.5 day p.c.,
TGF-beta1 and TGF-beta2 mRNA was detected in all three germ layers. In situ
hybridization and immunohistochemistry of the expression of the TGF-beta
type II receptor confirmed the data obtained by RT-PCR. Furthermore, the
type II receptor was detected in the extraembryonic ectoderm of 7.5 day
p.c. embryos. In the embryo proper. TGF-beta type II receptor expression
was detected only later in differentiating tissues and developing organs,
but not in the brain and neural tube. Since the expression of the type II
receptor may essentially determine whether a cell is able to respond to
TGF-beta, the results are consistent with the view that TGF-betas might be
implicated in embryo implantation and organogenesis, but are not involved
in gastrulation of the embryo.
Keywords: TGF-beta, receptor, mouse, embryo, gastrulation, implantation, organogenesis
Title: The organizer-associated chick homeobox gene, Gnot1, is
expressed before gastrulation and regulated synergistically by activin and
retinoic acid
- Authors:
- Knežević, Vladimir (156663)
- Ranson, Marie
- Mackem, Susan
Journal: Development Biology
ISSN: 0012-1606
Volume: 171
Year: 1995
Number of references: 55
Language: engleski
Summary: Gnot1, a Not- (for notcohord) family homeobox gene, is
expressed in the chick pregastrulation blastoderm. Gnot1 expression in the
epiblast is upregulated as the posteriorly derived hypoblast moves forward
anteriorly to form a layer beneath it, which is of particular interest
considering the known inductive role of the hypoblast in axis formation in
the chick. Both activin and retinoic acid are able to activate Gnot1
expression in cultured blastodermal cells and show a strong synergistic
effect when applid in combination. Strong superinduction of Gnot1
transcripts in the presence of cyxloheximide also indicates the presence of
a potent and labile intracellular inhibitor capable of modulating Gnot1
expression. During gastrulation, Gnot1 transcripts become localized
specifically to tissues associated with "organizer" function (Hensen's
node, head process, notochord). The expression data and the response to
mesoderm inducing factors and axial "caudalizing" signals suggest that
Gnot1 may be involved in specification of the embryonic body axis and could
play a part in regulating features of the trunk/tail organizer in the chick
embryo.
Keywords: gastrulation, Hensen's node, notochord, homeobox gene, chick embryo
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