SVIBOR - Project code: 1-08-240

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

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Project code: 1-08-240


PROTEIN PARAMETERS OF REPRODUCTIVE HEALTH


Main researcher: ŠERMAN, DRAŠKO (46534)


Assistants
Type of research: basic
Duration from: 01/01/91. to 12/31/95.
Papers on project (total): 131
Papers on project quoted in Current Contents: 10
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of Biology
Address: Šalata 3
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0) 466 952
Phone: 385 (0) 466 923
Phone: 385 (0) 410 823
Fax: 385 (0) 424 001
E-mail: sermand@mamef.mef.hr
Summary: Proteins represent the final gene products which perform all thewide array of cell functions including the specific functions ofmammalian reproductive cells. Early embryonic development ofmammals represent a sensitive period for adverse effects andaction of various toxic agents, which endanger the reproductivesuccess and human health. Experimental animals and their embryosenable the research on biological mechanisms supporting growth,morphogenesis and differentiation. Effects of active factorswhich influence development is being followed, as well as proteinchanges in embryo and reproductive cells in abnormal development(teratogenesis) and in human reproductive malignancy.ljudskog reprodukcijskog sustava (karcinogenezi).

Keywords: mammalian embryo, differentiation, growth, rodents, proteins, organ culture, morphogenesis, retinoic acid, 5-azacytidine, RB protein, lentoids, gynecological cancer, teratogenesis, carcinogenesis

Research goals: The goals are to learn about the role of some proteins (albumins, transferrins, RB protein) during diferentiation of the early mammalian embryo, when studied in vitro. The role of proteins like RB protein and p53 protein during embryonic development is a challenge relating embryology with oncology, so our next goal is to dedicate attention to protein indicators of malignant growth in gynecological malignancies. Serum proteins and antioxidant desmutagens in reproductive system will also be our goal, too. The nerve and muscle system, their development and action of taratogens, known morphogens (retinoic acid), and demethylation agents (5-azacytidine) are expected to yield interesting results.

COOPERATION - PROJECTS


  1. Name of project: UNWHO89/YUG/SMA2 SPECIAL PROGRAMME OF RESEARCH IN HUMAN REPRODUCTION
    Name of institution: United Nations - World Health Organization, Special Programmeof Research, Development and Research Training in Human Reproduction
    City: MD21218 - Baltimore, U.S.A.

COOPERATION - INSTITUTIONS


  1. Name of institution: The Johns Hopkins University, Department of Biology
    Type of institution: University/Faculty
    City: MD21218 - Baltimore, U.S.A.

  2. Name of institution: Karolinska Hospital, Institute of Tumor Biology
    Type of institution: University/Faculty
    City: Stockholm, Sweden

  3. Name of institution: New York Psychiatric Institute, Columbia University
    City: New York, U.S.A.

  4. Name of institution: Thomas Jefferson Medical College, Department of Pathology
    City: Philadelphia, U.S.A.

  5. Name of institution: UNESCO Program Čovjek i biosfera (MAB-Man And Biosphere)
    Type of institution: International organization
    Type of cooperation: Joint project
    City: 10000 - Zagreb, Croatia

  6. Name of institution: IUCN-The World Conservation Union-Education and Communication
    Type of institution: International organization
    Type of cooperation: Systematic exchange of information
    City: Gland, Švicarska

OTHER ACHIEVEMENTS


  1. Name: Europe Environment '93. Comments on the Report of theCommission of European Communities DGXI Nuclear Safety, Task Force requested by IUCN-World Conservation Union, East-West Environment, London, March 12, 1993
    Type of achievement: Studies of conduct
    Authors: Šerman Draško

  2. Name: Mandate for Life on Earth
    Type of achievement: Catalogues, address books,
    Authors: Šerman Draško

  3. Name: Earth Day, April 22, Coordination
    Type of achievement: Catalogues, address books,
    Authors: Šerman Draško

  4. Name: Reflexion on regional problems on environment and development in eastern and western Europe. Group de Vezelay Meeting, Athens, April 23-24, 1993
    Type of achievement: Studies of conduct
    Authors: Šerman Draško

  5. Name: European Union for Coastal Conservation, 4th International Conference on "Coastal Management and Habitat Conservation, Marathon, April 23-24, 1993, Attendance
    Type of achievement: Catalogues, address books,
    Authors: Šerman Draško

  6. Name: Les consequences de la guerre sur l'environment en Ex-Yougoslavie. Lecture at European Environmental Bureau, Brussels, May 6th, 1993
    Type of achievement: Other
    Authors: Šerman Draško

  7. Name: Contribution to the Action Plan for Protected Areas in Europe, IUCN World Conservation Union, Hugh Synge, CNPPA
    Type of achievement: Other
    Authors: Šerman Draško
Other information about the project.
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