SVIBOR - Project code: 1-08-292

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 1-08-292


THE INFLUENCE OF CHEMICAL SUBSTANCES ON BIOPHYSICAL PARAMETERS OF THE CELLS


Main researcher: ŠOLIĆ, FRANJO (47785)



Assistants
Type of research: basic
Duration from: 06/10/91. to 06/10/94.

Papers on project (total): 8
Institution name: Medicinski fakultet, Rijeka (62)
Department/Institute: DEPARTMENT OF PHYSICS
Address: Braće Branchetta 20
City: 51000 - Rijeka, Croatia
Communication
Fax: 385 (0)51 / 22 74 69
Fax: 385 (0)51 / 51 49 15
E-mail: Franjo.Solic@mamed.medri.hr

Summary: The purpose of this project is the investigation of the influence of some chemical substances with different degree of toxicity, on the essential biophysical parameters of biological sistems (bioeletric potentials, ions current, bioluminiscence, free radicals). From obtained results deduce conclusions abouth the applicability of research in detection of contamination of enviroment and in identification of pollutant at very low concentrations.

Keywords: biophysical parameters, chemical substances, effect

Research goals: The purpose of this project is the investigation of the influence some chemical substances on the essential biophysical parameters of biological sistems (bioeletric potentials, ions current, bioluminiscence, free radicals), and to find out possible correlation between the changes of biophysical parameters caused by certain chemical substance and conditions of effect. The influence of the dispergent hemisol on the resting potential of plant cells were detected. In investigated concentrations interval, the hemisol provocated the depolarisation of membrane, proporcional with the concentration. However, at the dispergent concentration of 0,01 %, the hyperpolarisation of membrane was occured in 60 % of cells. The time gradient of potentials change, caused with concentrations changes, is in positive correlation with the initial value of resting membrane potential in no contaminated solution only at lowest concentration of dispergent. With increase of dispergent concentrations, the correlation disappears. In some cells after the change of concentration the oscillation of membrane potential was occured. This is in agreement with our observation pyblished early, that the oscillations grow out after the rapidly depolarisation of cells membrane. The membrane hyperpolarisation and correlation between the time gradient of potential changes and the initial value of resting potentials at lowest concentration, may be connected with reversibile changes induced by dispergent. This assumption requires additional investigations. All the investigations have not been completed, and therefore the results are not completely elaborated.


COOPERATION - INSTITUTIONS


  1. Name of institution: INSTITUT "JOŽEF STEFAN" LJUBLJANA, Jamova 39
    Type of institution: State institute
    Type of cooperation: Other
    City: 61 111 - Ljubljana, SLOVENIJA

  2. Name of institution: BOTANICHES INSTITUT-UNIVERSITAT BONN, Venusbergweg 22
    Type of institution: University/Faculty
    Type of cooperation: Other
    City: 5300 - BONN, DEUTSCHLAND

  3. Name of institution: ZAVOD ZA MEDICINSKU FIZIKU, GINEKOLOŠKI CENTAR ZAGREB, Petrova 13
    Type of institution: Institution whose primary activities ar
    Type of cooperation: Other
    City: 10000 - Zagreb, Croatia

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Last update: 11/02/95
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