SVIBOR - Project code: 3-01-002

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
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SVIBOR - Collecting Data on Projects in Croatia

Project code: 3-01-002

AGING AND FUNCTIONAL CHANGES OF HUMAN ORGANS

Main researcher: DURAKOVIĆ, ZIJAD (10962)

Assistants

ŠMALCELJ, ANTON (98242)
BOGDAN, IVAN (159756)
JELIĆ, IVAN (75970)

Type of research: basic
Duration from: 01/01/91. to 12/31/93.

Papers on project (total): 71
Papers on project quoted in Current Contents: 8

Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of Internal Medicine,Rebro University Hospital, Medical Faculty University of Zagreb Clinic Hospital Center,Croatia
Address: Kišpatićeva 12
City: 10000 - Zagreb, Croatia

Communication: Phone: 385 (01) 2333233/303

Summary: The data of the group elderly patients treated in the intensive care unit, Department of internal medicine during 10-year period are analyzed. The main reason for hospitalization in the elderly was cardiovascular diseases, compared with gastroenterological diseases which have been the main reason in younger patients. The data of the clinico-epidemiological study in the sisx regions of Croatia were analyzed: 3 at the coast and the in the interior of the country, including 588 persons of both sexes and compared with those data of a younger persons : aged 35.54 and 22-41 years. In the eldrly group it was found more often myocardial fibrosis after myocardial infarction in an electrocardiogram, it was more often seen S-T segment depression and T-wave inversion and 60 times more often atrial fibrillation than in other groups, and pacemaker rhythm examinees. Renal diseases were studied in those persons. It was found proteinuria in allmost in one third in the elderly group compared with a finding in other. In the elderly arterial hypertension with heart changes was more often found than in youngers. Those data have to be calculated in planning of health protection of elderly patients. It was studied renal function in elderly patients treated in the Department of Internal Medicine, Rebro University Hospital in Zagreb, not suffered of renal diseases, a partial renal function were studied using a creatinine clearance analyzed by the biochemical method and compared with the four fast mathematical models using the serum creatinine concentration. It was found that the data given by the Cockroft and Gault's formula are worth for this analysis, and not other formulas. Renal function in elderly patients suffered of cardiogenic shock due to acute myocardial infarction Was studied. In was found that parameters of renal failure could not separate functional oliguria from acute tubular necrosis. There is no space for other results.

Keywords: cardiovascular disease in the eldrly, heart diseases in the elderly in population study, renal diseases in a population, renal diseases in the elderly, arterial hypertension in a population study, arterial hypertension in the elderly, myocardial infarction, cardiogenic shock, parameters of renal failure in the elderly, fast metods for analyzing of creatinine clearance in the elderly.

Research goals: The aim of this work is divided into seven parts: 1. the analysis of a group of patients treated in the Division of Cardiology, Department of Internal Medicine, Rebro University Hospital, the analysis of date given by the clinico-epidemiological study in six regions of Croatia, the analysis of the data of the Intensive Care Unit regarding elderly patients; 2. the analysis of the cardiovascular changes in persons without cardiovascular diseases, according to age groups: 41-50, 51-60, 61-64, 65-74, 75-84 years, according to a clinical finding, an electrocardiogram, an echocardiographic findings in patients from the Division of Cardiology, Rebro; 3. the analysis of the heart's function in elderly patients (80-100)compared with those findings in middle-aged patients (100-200), with the special reference to the severity of arterial hypertension; 4. the analysis of the echocardiographic finding in elderly patients in comparison with other parameters(a question: which heart diseases are dominant in the elderly, and which are unusual finding); 5. the analysis of results after heart surgery in elderly patients in comparison with results in other age groups(evaluation a therapeutic place of heart susrgery procedures in the elderly); 6. the analysis of renal function in the elderly without renal diseases, the frequency of renal diseases in our population and in an intensive care unit, the analysis of a course of illnes in the elderly with acute renal failure; 7. the analysis of rational pharmacotherapy in the elderly according to diseases.

Other information about the project.


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