The metabolism of iodine and thyroid hormons in degenerated thyroid gland
Main researcher
: SOLTER, MILJENKO (74594) Assistants
TIŠLARIĆ, DUBRAVKA (65684)
POSAVEC, LJUBICA (61860)
SISEK, MIRNA (900004)
Type of research: basic Duration from: 04/30/91. to 04/30/96. Papers on project (total): 4
Papers on project quoted in Current Contents: 1
Institution name: Medicinski fakultet, Zagreb (108) Department/Institute: Institute for endocrinology, diabetes and metabolic diseases Department for internal medicine University hospital "Sestre milosrdnice" Address: Vinogradska c. 29, Zagreb City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)174-666/682
Summary: On the bases of present knowledge about iodine prophylaxis
in our country, we are going to investigate the influence of iodine intake
on endemic goiter. We shall investigate the influence of altered
thyrotropin secretion on thyroid hormons biosynthesis in thyroid tissue. By
investigating the ability of T4 deiodination to T3 and reverse T3 in
thyroid tissue in vitro, we aim to light up the capacity of hormone
synthesis in various pathologycal tissues of thyroid gland.
Research goals: We are planning to investigate the influence of the
iodine intake on goitrogenic potential in our population particurarly
considering the secretion of TSH as the basic goitrogenic principle thus to
explain the relationship between the iodine intake and developement of the
sporadic goiter in our country. To contribute further to the knowledge
about thyroid hormone biosynthesis in degenerated thydoid tissues, the
intrathyroidal concentration of thyroid hormons in conditions of altered
TSH secretion will be investigated. We've modified our method for
determination of intrathyroid content of thyroid hormons in tissue
homogenates from thyroids obtained during operation. We shall also
investigate some aspects of hormone synthesis in cold nodule and other
pathologycal thyroid tissue (measuring the activity of 5 and 5'
deiodinases). Thus we would test hypothesis that pathological thyroid
tissue under conditions of good or even incresed activity of TSH produces
more T3 than T4. Other information about the project.