SVIBOR - Project code: 3-01-034

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-034


HORMONAL AND METABOLIC FACTORS IN DEVELOPMENT OF ATHEROSCLEROSIS


Main researcher: REINER, ŽELJKO (65232)



Assistants
Type of research: basic
Duration from: 07/01/91. to 07/01/95.

Papers on project (total): 50
Papers on project quoted in Current Contents: 19
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: DEPARTMENT OF PATHOPHYSIOLGY, UNIVERSITY HOSPITAL ZAGREB,
Address: KIŠPATIĆEVA 12, ZAGREB
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)41 215 330
Fax: 385 (0)41 229 669

Summary: Since changes in serum levels of different hormones, especially sex hormones, and prostaglandins can affect the development of atherosclerosis, the interrelationships of these supstances and serum lipoproteins will be studied. The concentrations of serum lipoproteins and apoproteins as well as prostaglandins PGI2 and TxA2 will be investigated in patients with coronary heart disease, periferal arteries atherosclerosis as well as retinal arteries atherosclerosis and correlation of these parameters with the extent of disease will be studied. Serum concentrations of lipoproteins in patients with hormonaly dependent disease breast cancer will also be studied and the influence of hormonal treatmentof these patients on their lipoproteins concentrations will be evaluated. The effect of noise induced stress on different hormones will also be studied since stress is considered to be important risk factor for atherogenesis. Patients with kidney failure, especially those undergoing hemodialysis, have much earlier and more severe atherosclerotic lesions than the others.Therefore, the influence of renal fonction parameters and hemodialysis on different hormones concentrations will also be studied. The effects of different nutritive influences and antilipemic drugs on serum lipoproteins and apoproteins concentrations will be studied as well in order to get more informations not only about the development of atherosclerosis but also about the possibilities of stopping the process or even to achieve the regression.

Keywords: Atherogenesis, serum lipoproteins, coronary heart disease, prostaglandins, kidney failure, sex hormones

Research goals: The geneal aim of the project is to contribute to the understanding of interactions between serum lipoproteins and different hormones, particulary sex hormones, and their role in the development of atherosclerosis, coronary heart disease, stroke etc. cause more than 50% of all the deaths in Croatia and in other western countries as well, the importance of this problem could be clearly seen. At clinical level the knowledge about hormonal and other metabolic changes connected with atherogenesis would suggest the prognostic value of these parameters. Also this project should give informations about atheroslerosis development in arteries which were never studied until now ( eg. retinal arteries ), or about which there are only few data ( peripheral arteries ). Almost nothing is known until noww about the effects of noise induced stress on humans. Therefore data about the effects of this type of stress to which many people are exposed on hormonal levels could also provide valuable insight into stress as risic factor for atheroslerosis.

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Last update: 12/26/93
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