SVIBOR - Project code: 3-01-062

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-062

EVALUATION OF THE TREATMENT OF PATIENT WITH TETANUS

Main researcher: LISIĆ, MIROSLAV (94971)

Assistants

Type of research: applied
Duration from: 01/01/91. to 12/31/94.

Papers on project (total): 4

Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Intensive care iunit for infectious diseases Hospital for infetious diseases "Dr. Fran Mihaljević"
Address: Mirogojska 8
City: 10000 - Zagreb, Croatia

Communication: Phone: 385 (01) 4557222; Phone: 385 (01)4557222; Fax: 385 (01)425-907; Phone: 385 (01) 4557222; Phone: 385 (01) 4557222; Phone: 385 (01) 4557222; Fax: 385 (01) 425907; Phone: 1; Fax: 385 (0)1 425907; E-mail: 385 (0)1; Fax: 385 (01) 425907; Phone: 385 (01) 4557222; Phone: 385 (01)4557222; E-mail: 0

Summary: A prospective study with a view to establish if the rate of Human Tetanus Immunoglobulin (HTIG) applicated intratecally changes the mortality from this disease was done. We also wanted to find out to which degree of the wasteness of the illness the rate has the influence and also the financial influence of the treatment when the higher dose of HTIG is applicated. The total of 114 patients with tetanus, treated at the University Hospital of Infectious Diseases "Dr. Fran Mihaljević", in the period from 1991 to 1994 were included into the study. They were divided in two groups. The first group (73 patients) were treated with "classical" therapy - HTIG applied intramuscularly, and also with 4000 IU of HTIG intratecally (Tetavenin, IMMUNO). The second, control group (55 patients) were treated with 2000 IU of HTIG intratecally as an addition to "classical" therapy. There were 24 patients (32.9%) in the first group who died, and in control group there were 10 patients (18.2%) who died. As conclusion of this study we can maintain that: 1. there is no statistical significance at the mortality of the patients with tetanus (Chi Squared Test = 2.76; P = 0.10) treated with 4000 IU of HTIG applied intratecally and 2000 IU of HTIG. 2. the application of 2000 IU of HTIG applied intratecally is more cheaper and more simplier than the first one.

Keywords: Tetanus, Treatment, Human Antitetanus Gamaglobulin (HTIG) - Intratecally

Research goals: The aim of this project is to determine through a prospective study:1. is there any statistically significant difference in themortality of the patients suffering from tetanus when 4000 IU or 2000 IU of HTIG are intratecally applied. 2. if thedifference exists, to find out on which level of the illness it appears. 3.If the difference exists, to find out which way of the treatmentto choose.

COOPERATION - INSTITUTIONS

Name of institution: Klinika za infektivne bolesti "Dr. Fran Mihaljević"
Type of institution: International organization
City: 10000 - Zagreb, Croatia

Other information about the project.


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Last update: 10/09/95
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