SVIBOR - Project code: 3-01-067

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

SVIBOR - Collecting Data on Projects in Croatia

Project code: 3-01-067


FACTORS OF ONCOGENESIS IN HUMAN PITUITARY TUMORS


Main researcher: TEPAVČEVIĆ, DANILO (49335)


Assistants
Type of research: basic
Duration from: 01/01/91. to 12/31/95.
Papers on project (total): 24
Papers on project quoted in Current Contents: 3
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Division of endocrinology and metabolism Department of internal medicine Rebro School of medicine University of Zagreb
Address: Kišpatićeva 12, Zagreb, Croatia
City: 10000 - Zagreb, HRVATSKA
Communication
Phone: 385 (0) 1 21 72 80
Phone: 385 (0) 1 2333 233 (297,299,220)
Fax: 385 (0) 1 21 72 80
Summary: Gangliosides are involved in modulation of cell membrane receptors, especially those for "growth factors", their content and structure alteration might be connected with the cell's malignant transformation, and therefore their investigation might enrich our knowledge and further understandings on pathogenesis of anterior pituitary tumors of endocrinologists as well as oncologists, that might certainly bring us to more successfull treatment of these lesions. The aim of our investigation is to establish the quantitative and qualitative characteristics of ganglioside fractions in serum and tumorous tissues as well, to delineate them according to the kind of secreting hormones, and their pathohistologic features, so in that way to determine pathognomonic "markers" for the reliable diagnosis and differential diagnosis of existing lesions. By means of monoclonal cell lines from the tumor tissue cultures we intend to define the characteristic ganglioside fractions, and more thoroughly the secreting hormones as well. By pretreatment with the available "growth factors", stimulating and inhibiting ones, and hypothalamic releasing hormones, we hope to identify their mutual interconnection in the oncogenetic process of pituitary tumors. Such understandings might disclose the creation of critical antibodies for the diagnosis by means of specific "markers", as well as for the eventual nonaggressive therapy.

Keywords: "growth factors" - gangliosides - oncogenesis - anterior pituitary tumors

Research goals: The general aim of our investigation is to get acquainted further with structural and functional features of gangliosides in the whole normal pituitary and in anterior pituitary tumors, as one of the possible "growth factors" or a receptor for "growth factors" in the malignent transformation of cells. The first and unique data in the literature on the elevated serum gangliosides levels in acromegaly, as well as the first and unique analysis of tissue gangliosides in the anterior and posterior lobes of the normal subjects and patients with hormonally active pituitary adenomas, are the result of our studies. By defining the specific "markers" for various anterior pituitary adenomas, we will be able to discover the recurring lesions of the unsuccessfully operated patients at earliest possible term. One of the therapeutical approaches in the treatment of the anterior pituitary tumors could be the inhibition of autocrine and paracrine actions of "growth factors" by means of antibodies or synthetic peptides, i.e., by means of directing the toxin-antibodies onto the cell surface "growth factors".

COOPERATION - PROJECTS


  1. Name of project: 3-01-082 NEUROTRANSMITERI U REGULACIJI ADENOHIPOFIZE
    Name of institution: MEDICINSKI FAKULTET, Zavod za endokrinologiju Interne klinike KBC REBRO
    City: 10000 - Zagreb, HRVATSKA

COOPERATION - INSTITUTIONS


  1. Name of institution: Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Zagrebu
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, HRVATSKA

  2. Name of institution: Endokrinološki laboratorij Interne klinike Kliničkog bolničkog centra Rebro
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, HRVATSKA
Other information about the project.
MZT Croatian language SVIBOR Alphabetic list Sorted on project code Sorted on institutions Search help
Ministry of
Science and
Technology		 Croatian
language		 Svibor
homepage		 Alphabetic
list		 Sorted on
project code		 Sorted on
institutions		 Search Help
Last update: 10/12/95
Information: svibor@znanost.hr