SVIBOR - Project code: 3-01-074

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

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Project code: 3-01-074


BONE MARROW TRANSPLANTATION


Main researcher: LABAR, BORIS (75966)


Assistants
Type of research: applied
Duration from: 01/01/91. to 12/31/94.
Papers on project (total): 48
Papers on project quoted in Current Contents: 26
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: UNIVERSITY HOSPITAL REBRO DEPARTMENT OF MEDICINE DIVISION OF HAEMATOLOGY
Address: Kišpatićeva 12
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (1) 2 333 368
Phone: 385 (1) 2 333 233/611
Phone: 385 (1) 2 333 233/601
Phone: 385 (1) 2 333 233/631
Phone: 385 (1) 2 333 233/277
Phone: 385 (1) 2 333 233/251
Fax: 385 (1) 2 333 368
Summary: The aim of this project is to study particular phases of bone marrow transplantation in order to improve the results of treatment, especially of malignant diseases. Programs of intensive preparative regimens for transplantation, complications and their frequency as well as diagnostic will be investigated. The special emphasis will be given to improvement of prophylactic approach and management of complications of the graft-versus-host disease and infections. The value of this method in the treatment of malignant lymphomas and immunoproliferative disorders as well as usefulnes of the peripheral stem cell transplantation will be assesed. The efficacy of cytokines on the function on marrow transplant as well as their potential antitumour effect will be studied particulary in patients with leukemia. Voluntary marrow donor registry will be made which is necessary for assesment of unrelated marrow transplantation in Croatia.

Keywords: allogenic and autologous bone marrow, transplatation, stemm cells, complications (infections, GVHD), chimerism, cztokines, leukemia, malignant lzmphomas, immunoproliferative diseases, severe aplastic anaemia

Research goals: Aims and results I. Evaluation of conditioning regimens and function of marrow graft with expanding BMT programm to other diseases: 1. To compare efficacy of busulfan and cyclophosphamide to standard total body irradiation and cyclophosphamide in allogeneic and autologous BMT 2. To evaluate efficiency of autologous BMT in the treatment of high grade malignant lymphomas 3. To study the effect of addition of the peripheral blood stem cells on the marrow recovery after BMT 4. To investigate prognostic factors influencing on marrow recovery after BMT 5. To asses the value of peripheral blood stem cell transplantation in the treatment of hematological malignancies 6. To evaluate the effect of various cytokines on marrow recovery II. Evaluation of incidence, diagnostic approach, prophylaxis and treatment of graft versus host disease 1. Diagnostic value of immunohistochemistry and finding of AgNOR bodies in the skin and intestine of the patients with GVHD 2. Clinical and laboratory prognostic factors influencing GVHD 3. Prophylaxis of acute GVHD using immunoglobulin with other immunosuppressives 4. To estimate efficacy of "in vitro" marrow treatment with cyclosporine and corticosteroid as a GVHD prophylaxis 5. To evaluate efficency of systemic GVHD prophylaxis after BMT 6. To study the incidence of infections with resistant bacterial in immunocompromized patients 7. To study the incidence of fungal infections after BMT 8. To study the incidence of CMV infections and to determine optimal diagnostic approach to those patients after BMT III. Determination of factors influencing leukemia relapse 1. The value of chimerism after marrow transplantation and its relation to leukemia recurrence 2. Use of interferon alpha, interleukin-2 and LAK cells in prophylaxis of leukemia recurrence in patients treated with marrow transplantation IV To determine therapeutic effect of unrelated marrow transplantation 1. Establishment of unrelated marrow donor registry 2 To estimate efficacy of HLA identical unrelated marrow grafting Expected achievements 1. Improvement of marrow transplantation, improvement of basic diagnostic procedures for treatment related complications, better prophylaxis of treatment related complications 2. Expanding of marrow grafting programme to other diseases like malignant lymphomas and immunoproliferative disorders 3. New diagnostic and therapeutic procedures might have benefit for other specialties.

COOPERATION - PROJECTS


  1. Name of project: JF 917 CLINICAL BONE MARROW TRANSPLANTATION
    Name of institution: FRED HUTCHINSON CANCER CENTRE, Seattle, Washington USA
    City: Seattle, USA

  2. Name of project: 3-01-075 Leukemije
    Name of institution: Medicinski fakultet Sveučilišta u Zagrebu
    City: 10000 - Zagreb, Croatia

COOPERATION - INSTITUTIONS


  1. Name of institution: Hammersmith Hospital, Royal Postgraduate Medical School, Leukemia Unit, Department of Haematology
    Type of institution: University/Faculty
    Type of cooperation: Systematic exchange of experts
    City: W120NN - London, UK

  2. Name of institution: University of Munchen, Ludwigs-Maximilian Universitaes, Klinikum Grosshadern
    Type of institution: University/Faculty
    Type of cooperation: Systematic exchange of information
    City: Munchen, D

  3. Name of institution: Fred Hutchinson Cancer Research Center, Seattle, Wa, USA
    Type of institution: University/Faculty
    Type of cooperation: Joint project
    City: Seattle, USA

  4. Name of institution: The University of Connecticut Health Center, Farmington, USA
    Type of institution: University/Faculty
    Type of cooperation: Occasional exchange of information
    City: Farmington, USA

  5. Name of institution: Anthony Nolan Registry
    Type of institution: International organization
    Type of cooperation: Other
    City: W120NN - London, UK

  6. Name of institution: INTERNATIONAL BONE MARRW TRANSPLANT REGISTRY
    Type of institution: University/Faculty
    Type of cooperation: Systematic exchange of information
    City: MILWAUKEE, SAD

  7. Name of institution: EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER-Leukaemia group
    Type of institution: International organization
    Type of cooperation: Joint project
    City: Brusseles, Belgium

  8. Name of institution: INTERNATIONALE GESSELSCHAFT FUER CHEMO-IMMUNOTHERAPIE
    Type of institution: International organization
    Type of cooperation: Joint project
    City: BEČ, ASUTRIA

  9. Name of institution: EUROPEAN BONE MARROW TRANSPLANT GROUP
    Type of institution: International organization
    Type of cooperation: Systematic exchange of information
    City: BASEL, SWITZERLAND
Other information about the project.
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