SVIBOR - Project code: 3-01-087


Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69


SVIBOR - Collecting Data on Projects in Croatia

Project code: 3-01-087


Main researcher: PEGAN, BORIS (35894)

Type of research: developmental
Duration from: 01/01/91. to 12/31/95.

Papers on project (total): 0
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital "Sestre milosrdnice", Zagreb
Address: Vinogradska 29
City: 10000 - Zagreb, Croatia

Summary: Function of the aerodigestive crossing following total nose obstruction was studied on an experimental model. The nasopulmonary reflexes were evaluated in a group of patients with total laryngectomy under various experimental conditions. The difficulties concerning aspiration in the patients following surgery of the aerodigestive crossing were discussed. An analysis of voice and speech following total laryngectomy was done in order to find out what type of the rehabilitation procedure would be the most efficient. The intubation sequelae and the need of a timely tracheostomy werw also studied so as to prevent the disability of decannulation performance. The squamos cell carcinoma of the larynx and infiltration into the cartilage of the larynx were also analyzed. Contemorary clinical preoperative investigations were utilized to analyze the larynx, the hypopharynx and the aerodigestive crossing area. An analysis of the macroscopic horizontal slices was made and the infiltration of cancer into the laryngeal cartilage was discused. The results we obtained with this procedure were then compared to those we obtained with some other up-to-dated diagnostic procedures. Our properative evaluation of the infiltration into the epiglottic cartilage was a success as was a cancer spread evaluation into the preepiglottic space. The importance of utilization of the latest complex diagnostic procedures in the menagement of transglottic carcinoma was pointed out. The procedures were evaluated to be of grat use for both: to meet the needs of oncologic demands, and for the aerodigestive crossing function following surgery.

Keywords: malignant tumor, aerodigestive crossing, respiratory function, deglutation, aspiration, voice and speech

Research goals: The research we deal with has been focused on few fundamental issues concerning malignant tumors of the aerogigestive srossing. The aim of the research was to find out what type of a complex oncologic approach is the most efficient. For these purpose, we did some research of respiratory and digestive functions and evaluated the voice and speech qualities - all with respect to a type of surgery performed. Our pimary concer was preoperative estimation and multilateral evaluation of surgical specimens in our patients. The reconstructions for tongue base tumor is often troublesome, especialy from the functional point of view. As of respiratory function, it is mainly related to the early postoperative stage of a patient: depending on the condition surgery may be done either with or without tracheostomy, a big discomfort for a patient. If tracheostomy is required, the primary questions that arises is the decanulation with regard to the postoperative aspiration. The research of respiratory function we have done so far on an experimental model makes an important contribution offering the answers to the questions we've been looking for. Another aim of our research is to evaluate the effect the thyroide hormones maight have on the head and neck region. The evaluation of the differences in hormonal activities between the thyroid tissue samples, and comparison of the results has also beeen in the focus of our research.

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Last update: 10/09/95