COMPLEX ONCOSURGICAL APPROACH TO THE CARCINOMA OF THE AERODIGESTIVE CROSSING
Main researcher
: PEGAN, BORIS (35894) Assistants
BOSNAR, MARIJAN (97533)
KALOGJERA, LIVIJE (161416)
ŠTAJNER, SMILJANA (99906)
NIKŠIĆ-IVANČIĆ, MARIJA (33440)
Type of research: developmental Duration from: 01/01/91. to 12/31/95. Papers on project (total): 0
Institution name: Medicinski fakultet, Zagreb (108) Department/Institute: Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital "Sestre milosrdnice", Zagreb Address: Vinogradska 29 City: 10000 - Zagreb, Croatia
Communication
Summary: Function of the aerodigestive crossing following total nose
obstruction was studied on an experimental model. The nasopulmonary
reflexes were evaluated in a group of patients with total laryngectomy
under various experimental conditions. The difficulties concerning
aspiration in the patients following surgery of the aerodigestive crossing
were discussed. An analysis of voice and speech following total
laryngectomy was done in order to find out what type of the rehabilitation
procedure would be the most efficient. The intubation sequelae and the need
of a timely tracheostomy werw also studied so as to prevent the disability
of decannulation performance. The squamos cell carcinoma of the larynx and
infiltration into the cartilage of the larynx were also analyzed.
Contemorary clinical preoperative investigations were utilized to analyze
the larynx, the hypopharynx and the aerodigestive crossing area. An
analysis of the macroscopic horizontal slices was made and the infiltration
of cancer into the laryngeal cartilage was discused. The results we
obtained with this procedure were then compared to those we obtained with
some other up-to-dated diagnostic procedures. Our properative evaluation of
the infiltration into the epiglottic cartilage was a success as was a
cancer spread evaluation into the preepiglottic space. The importance of
utilization of the latest complex diagnostic procedures in the menagement
of transglottic carcinoma was pointed out. The procedures were evaluated to
be of grat use for both: to meet the needs of oncologic demands, and for
the aerodigestive crossing function following surgery.
Research goals: The research we deal with has been focused on few
fundamental issues concerning malignant tumors of the aerogigestive
srossing. The aim of the research was to find out what type of a complex
oncologic approach is the most efficient. For these purpose, we did some
research of respiratory and digestive functions and evaluated the voice and
speech qualities - all with respect to a type of surgery performed. Our
pimary concer was preoperative estimation and multilateral evaluation of
surgical specimens in our patients. The reconstructions for tongue base
tumor is often troublesome, especialy from the functional point of view. As
of respiratory function, it is mainly related to the early postoperative
stage of a patient: depending on the condition surgery may be done either
with or without tracheostomy, a big discomfort for a patient. If
tracheostomy is required, the primary questions that arises is the
decanulation with regard to the postoperative aspiration. The research of
respiratory function we have done so far on an experimental model makes an
important contribution offering the answers to the questions we've been
looking for. Another aim of our research is to evaluate the effect the
thyroide hormones maight have on the head and neck region. The evaluation
of the differences in hormonal activities between the thyroid tissue
samples, and comparison of the results has also beeen in the focus of our
research. Other information about the project.