SVIBOR - Project code: 3-01-106

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-106


Influence of environment contamination on perinatal and child morbidity


Main researcher: JUKIĆ, STANKO (99482)


Assistants
Type of research: applied
Duration from: 01/01/91. to 12/31/94.
Papers on project (total): 54
Papers on project quoted in Current Contents: 3
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Medical University Clinical department for pathology Department for gynecological and perinatal pathology
Address: Petrova 13
City: 10000 - Zagreb, Croatia
Communication
Fax: 385 (0)1 444-279
Summary: The concentratons of lead, cadmium, mercury and radioactive cesium in the tissues of: malformed fetuses, non-malformed fetuses and neonates and children that dies of malignant diseases will be studied. The samples will consist of 200 fetuses, neonates and children. The attempt to prove whether the difference in the concentration of these metals exist between the fetuses, neonates and children from rural and urban environment will also be made. Also, the attempt to prove whether the concentration of radioactive cesium in the sceletal and soft tissues of the malformed fetuses and children that died of malignant disease is different from the concentration in the same tissues in non-malformed neonates and children that died of other causes than malignant diseases. It will be tried to prove the amount of influence of the female genital tract inflammations on the number of abortions and preterm deliveries (and still very high perinatal mortality). The samples of fetal membranaces, amniotic fluid, placentas and neonatal blood will be taken for the microbiological analysis.

Keywords: environment, contamination, haevy metals, radioactive cesium, microorganisms, fetus, praematurus, malformations, perinatal mortality

Research goals: Lead toxicity is well proven, and it is supposed that it has carcinogen influence. Since it accumulates in bones, and in lesser amount in other tissues, its toxic influence with every positive consequence is supposed. Because of its transplacental transportation it is possible to expect that it will accumulatein fetal sceletal system. The differnce between the concentrations in fetuses from rural and urban environment will be of interest, as well as the difference in lead concentrations in malformed and non-malformed fetuses. The same study will be made in live born children that died of malignant diseases. 2.The same study will be made also for cadmium and mercury. Chemical combinations having in mind the possible prevention of haevy metal enviroment contamination resulting in the lesser number of malformed fetuses, and malignant diseases in childhood period. 3. Since radioactive cesium degradation half time is 30 years, we expect to find its elevated concentrations not only in the tissue children as well. It will be intersting to find out whether the radiactive cesium concentrations will be higher in tissues of malformed neonates (and in which malformations), inrelation to non-malformed children. 4. In the cases of pregnancies where certain microbiological agens is found, we want to evaluate whether the intensity of jeopardy is dependent of the causative factor itself, and whether it was present before in thegenital tract. The aim will be to prevent the infection and its influence to the number of preterm diseases.

COOPERATION - INSTITUTIONS


  1. Name of institution: Klinika za ženske bolesti i porode
    Type of institution: Institution whose primary activities ar
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  2. Name of institution: Zavod za zaštitu majke i djeteta
    Type of institution: Institution whose primary activities ar
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  3. Name of institution: Medicinski centar Vinkovci
    Type of institution: Institution whose primary activities ar
    Type of cooperation: Joint publishing of scientific papers
    City: 32000 - Vinkovci, Croatia

  4. Name of institution: Zavod za nuklearnu medicinu KBC-a
    Type of institution: Institution whose primary activities ar
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  5. Name of institution: Veterinarski fakultet
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia
Other information about the project.
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