SVIBOR - Papers quoted in CC - project code: 3-01-108
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SVIBOR - Collecting Data on Projects in Croatia
Papers quoted in Current Contents on project 3-01-108
Quoted papers: 7
Other papers: 20
Total: 27
Title: Asian Indian HLA-DR2-,DR4- and DR52- Related DR-DQ
Genotypes Analyzed by Polymerase Chain Reaction Based Nonradioactive
Oligonucleotide Typing
- Authors:
- Mehra, Narider
- Bouwens, Anne
- Naipal, A
- Rajalingam, Raja
- Brubić, Zorana (176632)
- Taneja, Veena
- Tilanus, Marcel
- Giphart, M
Journal: Human Immunology
Number: 2
ISSN: 0198-8859
Volume: 39
Year: 1994
Pages: from 202 to 210
Number of references: 31
Language: engleski
Summary: We have employed a PCR-based nonradioactive technique using
biotinylated SSOPs to define HLA-DR2-, 4-, DR51-, and DR52- associted DR-DQ
genotypes in Asian Indian families. In the DR2 group, most haplotypes
described by us in a previous study were confirmed by family analysis.
Evidence for one additional haplotype was available in this study. The
classic DRB1*1501- and DRB1*1502-associated caucasoid haplotypes occured
with an appreciable frequency in Asian Indians, but two of the DRB1*1601-
associated Caucasoid haplotypes were absent. At least six unique and
unusual DR2 associated genotypes were encounted. In the DR52 group, the
three most common alleles are DRB1*0301, DRB1*1404 and DRB1*1101. The
DR6-associated alleles were DRB1*1301, 1302, 1401 and 1404. A few uncque
haplotypes occured with low frequency in this group. In the DR4 group, at
least three unusual patterns of hybridisation were noticed by family
analysis. One of these appears to be a novel DR4 subtype upon sequencing.
These results demostrate that, besides HLA-DR2, appreciable complexity
occurs in the DR4- and DR52-associated alleles among Asian Indians. The
presence of unique DR-DQ haplotypes in addition to those found
characteristically among Western Caucasians suggests that the Indian
population provides valuable source of many HLA class II haplotypes.
Keywords: polymerase chain reaction, sequence-specific oligonucleotide probe,Indian population,HLA DR-DQ haplotypes,
Title: Molecular analysis of HLA class II polymorphism in
Croatians.
- Authors:
- Brubić, Zorana (176632)
- Žunec, Renata
- Naipal, A
- Kaštelan, Andrija (20432)
- Giphart, M
Journal: Tissue Antigens
ISSN: 0001-2815
Year: 1995
Number of references: 21
Language: engleski
Summary: HLA-class II polymorphism have been studied in a population
of 141 unrelated healthy Croatians using PCR amplification, followed by
non-radioactive oligonucleotide hybridisation. Thirty one DRB1, 8 DQA1, 13
DQB1 and 16 DPB1 alleles were found in the tested population. DRB1*1601,
0701, 1501, 0101 and 1104 are the most frequent alleles at the DRB1 locus.
At DQA1 locus two alleles predominate: DQA1*0501 and 0102, while the most
frequent DQB1 allele is *0301. Analysis of HLA-DPB1 polymophism showed
that, as in other Europeans, DPB1*0401 is the most frequent allele. Four
different two locus haplotypic association (DRB1-DRB3, DRB1-DRB5, DRB1-DQb1
and DQA1-DQB1) as well as three locus DRB1-DQA1-DQB1 association were
assigned on the basis of known linkage disequlibria. Several unusual
two-locus associations have been observed: DRB1*0301-DRB3*0202,
DRB1*1501-DRB5*02, DRB1*1601-DRB50101, DRB1*1502-DRB5*0101,
DQA1*0103-DQB1*0503 and DQA1*0501-DQB1*0302. Among 236 examined
DRB1-DQA1-DQB1 haplotypes, the most frequent was
DRB1*1601-DQA1*0102-DQB1*0502 which was found with statistically
significante higher frequency than in other Europeans. Twenty eihgt
distinct haplotypes were observed just once, suggesting that the main
characteristic of Croatians is great heterogeneity of haplotypes. This
study will serve as a reference for further HLA and disease association
studies anf for donor/recipient matching in organ and bone-marrow
transplantation.
Keywords: Croatians,haplotypic associations, HLA-class II, population study, PCR-SSO
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