- Type of paper
: Paper in book
Title: HLA in five populations of southern Europe.
- Authors:
- Cuccia, M
- Astolfi, P
- Gyodi, E
- Kaštelan, Andrija (20432)
- Papasteriades, C
- Salerno, N
- Suicu-Foca,
- Veratti, A
- Editors
- Tsuji, K
- Aizawa, M
- Sasazuki, T
Publisher: Oxford University Press
Year: 1992
Pages: from 655 to 656
- Type of paper
: Paper in book
Title: Antigen Society No.207:HLA-DR8
- Authors:
- Nisperos, B
- Chung, K
- Hansen, J
- Hasegava, I
- Stewart, D
- Kawasaki, M
- Saitou, S
- Petranyi, G
- Kaštelan, Andrija (20432)
- Editors
- Tsuji, K
- Aizawa, M
- Sasazuki, T
Publisher: Oxford University Press
Year: 1992
Pages: from 372 to 375
- Type of paper
: Paper in journal
Title: Adrenocorticotropic hormone insensitivity associated with
autonomic nervous system disorders.
- Authors:
- Dumić, M
- Radica, A
- Sabol, Z
- Plavšić, V
- Brkljačić-Šurkalović, Ljerka (5595)
- Sarnavka, V
- Vuković, J
Journal: European Journal of Pediatrics
ISSN: 0340-6199
Volume: 150
Year: 1991
Pages: from 696 to 699
Number of references: 14
Language: engleski
Summary: Five children with adrenocorticotropic hormone
(ACTH)insensitivity with autonomic nervous system disorders aredescribed.
At the time of diagnosis,four of them hadosteoporosis. The fifth patient
died and skeletal roentgenogramswere not done. Osteoporosis was
subsequently discovered in one ofour previously reported patients with ACTH
insensitivity. Weassume that osteoporosis is,at least partly,the result
ofdecreased adrenal androgen production. Humane leucocyte antigentyping
failed to establish any linkage.
Keywords: ACTH insensitivity,Adrenal insufficiency,Autonomic nervous system disorders,Osteoporosis,HLA typing
- Type of paper
: Paper in journal
Title: Interferences with determination of 17-hydroxyprogesterone
in amniotic fluid.
- Authors:
- Plavšić, V
- Rogić, D
- Dumić, M
- Ille, J
- Brkljačić-Šurkalović, Ljerka (5595)
- Latin, V
Journal: Clinical Chemistry
ISSN: 0009-9147
Volume: 37
Year: 1991
Pages: from 2154 to 2155
Number of references: 6
Language: engleski
Summary: Continuing our work on the problems on congenital
adrenalhyperplasia we have established reference values
for17-hydroxyprogesterone (17-OHP) and androstenedione in amnioticfluid
(AF) and done 12 succesfull prenatal diagnosis in familiesat risk for CAH.
17-OHP was determined in AFs of 105 women in thesecond trimester of
pregnancy with a kit from Sorin-Biomedica. Inanother 80 pregnant women,
17-OHP was determined with newSorin-Biomedica kit, a DPC Coat-A-Count kit,
with and withoutether extraction, and a CIS Bio International coated-tubes
kit,with and without ether extraction. In conclusion, because of theas yet
unresolved problem of interference during 17-OHPdetermination in AF, we
don't recommend use of the DPC kit forprenatal diagnosis of CAH.
- Type of paper
: Paper in journal
Title: A novel diabetes-susceptibility HLA haplotype is present
in the Croatian population
- Authors:
- Đurinović-Bello, I
- Schendel, D.J.
- Kaštelan, Andrija (20432)
- Segurado, O.G.
Journal: Tissue Antigens
ISSN: 0001-2815
Volume: 41
Year: 1991
Pages: from 107 to 109
Number of references: 13
Language: engleski
Summary: We found that the MHC-linked susceptability alleles
andhaplotypes found in Croatian IDDM patients are similar to thosefound in
Central and Northern European populations, butrelatively distinct to the
other Mediterranean populations.However, we also report the presence of a
novel low frequencyhaplotype, HLA-A9 B21(49) DR3, that displays
intriguingsimilarities with IDDM susceptibility haplotypes found in
someMediterranean populations. Thus, the analysis of the geneticstructure
of this haplotype combined with studies from otherhaplotypes included the
HLA class II and complement class IIIallleles and other relevant
polymorphic genes such as TAP 1 andTAP 2 and proteasome alleles, will
provide additional insightinto the MHC genes which may contribute to
susceptibility toIDDM.
Keywords: haplotypes, HLA, insulin dependent diabetes mellitus, segregation analysis
- Type of paper
: Paper in journal
Title: The preexcitation syndrome:epidemiological and genetic
study
- Authors:
- Duraković, Z
- Duraković, A
- Kaštelan, Andrija (20432)
Journal: International Journal of Cardiology
Volume: 35
Year: 1992
Pages: from 181 to 186
Number of references: 22
Language: engleski
Summary: A sample of 4210 subjects of both sexes aged 35-54 years
wasexamined, choosen at random from six regions of Croatia.
Anelectrocardiogram at rest was performed in all subjects andchanges
analysed by the Minnesota code. A short P-R intervaltogether with a
widening QRS complex and delta wave was found in0,05% while 42 (1%) of the
examinees had a short P-R interval,but only 0,21% were symptomatic. Three
years after firstexamination 0,06% of the subjects have preexcitation with
deltawave, and in one subject it appeared after 3 years. 0,35% of
thesubjects had a short P-R interval after three years, but only0,18% were
symptomatic and in 22 (0,65%) it had dissappeared inthree years. Antigens
of the human leucocyte group (HLA) wereanalysed in 46 patients: the
Wolf-Parkinson-White syndrome wasfound in 35, while 11 had the
Lown-Ganong-Levine syndrome.Antigens of the HLA-A, -B and -DR loci were
determined by themycrolymphcytotoxicity method. There was an increased
frequencyof HLA-A9 and B5 (p=0,026 and 0,0092) in the
investigatedpopulation as whole. The participation of A3 antigen
wassignificantly less among patients (p=0,03), while B14 antigen wasnot
found in patients with preexitation. Within 10 HLA-DRantigens, DR7 antigen
was rather more frequently present,although this was statistically
significant (p=0,173).
Keywords: Preexcitation,Population study,Wolff-Parkinson-White syndrome,Lown-Ganong-Levine syndrome,Short P-R interval,HLA-system
- Type of paper
: Paper in journal
Title: A centromere-based genetic map of the short arm of human
chromosome 6.
- Authors:
- Blanche, H
- Zoghbi, H.Y.
- Jabs, E.W.
- DeGouyon, B
- Žunec, Renata
- Dausset, Jean
- Cann, Howard
Journal: Genomics
Number: 3
ISSN: 0888-7543
Volume: 9
Year: 1991
Pages: from 420 to 428
Language: engleski
Summary: A genetic map of the short arm of chromosomes 6 (6p) has
beenconstructed with 20 genetic markers that define 16 loci,includinga
locus at the centomere. The 40 CEPH families and,for 4 loci, 13additional
Utah families were genotyped. All 16 loci form asingle linkage group
extending from near telomeric region to thecentromere, covering covering
159 cM (Haldane) on the female mapand 94 cM on the male map. Sex
differences in recombinationfrequencies are noted for the 6p map with an
excess occuring inmales at the distal end. The genetic order of loci is
consistentwith their physical localization on 6p. Proximal to the threemost
distal loci on the map, markers are especially dense,providing an extending
region on 6p useful for localizating genesof interest.
- Type of paper
: Paper in journal
Title: HLA-DR and HLA-B antigens and disease expression in
rheumatoid arthritis
- Authors:
- Jajić, Zrinka
- Jajić, Ines
- Brkljačić-Kerhin, Vesna (5604)
- Pavlović, Svea
- Jajić, Ivo
Journal: Reumatizam
ISSN: 0374-1338
Volume: 39
Year: 1992
Pages: from 59 to 67
Number of references: 46
Language: engleski
Summary: Possible association between HLA-DR1, HLA-DR4, HLA-B27
antigensalone or in combinations and laboratory,radiological findings
andfeatures of clinical status were analysed in 175 patients withrheumatoid
arthritis. HLA-DR1 was associated significantly withthe absence of
vasculitis, Raynaud's phenomenon, tenosynovitisand sacroiliitis in
seronegative patients. HLA-B27 was associatedsignificantly with the less
swollen joints and tenosynovitis, andwith the presence of iritis,
sacroiliitis in seronegativepatients, shoulder involvment and reduced
Schober's test. HLA-DR1in combination with HLA-B27 was associated
significantly with thepresence of fourth development stage hip involvement
andincreased levels of serum C reactive protein. HLA-DR4 incombination with
HLA-B27 was associated significantly with thepresence of coxitis and feet
small joints involvement and reducedSchober's test. HLA-DR4, HLA-DR4 in
combination with HLA-DR1, andHLA-DR4 in combination with HLA-DR1 and B27
were not associatedsignificantly with differences in the presence of any
laboratoryfindings, radiological changes or other features of
clinicalstatus.
- Type of paper
: Paper in proceedings
Title: Leucocyte antigens and infertility
- Authors:
- Brkljačić-Šurkalović, Ljerka (5595)
- Humar, Ines (159135)
- Kaštelan, Andrija (20432)
- Singer, Zvonimir
- Editors
- Singer, Zvonimir
- Ciglar, S
Proceedings title: Trajno usavršavanje liječnika
Place: Zagreb
Year: 1993
Pages: from 51 to 53
Meeting: Uzroci i prevencija spontanih pobačaja
Held: from 10/01/93 to 10/01/93
- Type of paper
: Paper in proceedings
Title: HLA-DRB1, DRB3 and DRB5 polymorphism in a Croatian
population.
- Authors:
- Brubić, Zorana (176632)
- Žunec, Renata
- Giphart, M
- Naipal, A
- Kaštelan, Andrija (20432)
Proceedings title: Knjiga postera.
Language: engleski
Place: Zagreb
Year: 1995
Pages: from 43 to 47
Meeting: 11th International Antropological Poster Conference
Held: from 06/18/95
Summary: The gene frequencies and haplotypic association within the
HLA-DRB region have been investigated in 141 unrelated Croatians. DRB1,
DRB3 and DRB5 polymorphism were studied by using polymerase chain reaction
and sequence specific oligonucleotide probe (PCR-SSO) method. Thirty one
DRB1, 4 DRB3 and 3 DRB5 alleles were found in our population.
DRB1*1601,0701, 1501, 0101 and 1104 are the most frequent alleles at the
DRB1 locus. At the DRB3 locus the most frequent allele is *0202 while the
most frequent DRB5 allele is *0101. Two different Locus haplotypic
associations (DRB1-DRB3 and DRB1-DRB5) were assigned on the basis of known
linkage disequlibria. Four unusual two-locus associations have been
observed: DRB1*0301-DRB3*0202, DRB1*1501-DRB1*02, DRB1*1691-DRB1*0101 and
DRB1*1502-DRB5*0101. These data should be useful for the studies in
anthropology, organ transplantation and disease susceptibility in a
Croatian population.
Keywords: PCR-SSO, Croatians, HLA class II, population study
- Type of paper
: Paper in proceedings
Title: Analysis of segregation and inheritance in families with
HLA-B27 positive patient suffering from ankylosing spondylitis.
- Authors:
- Brubić, Zorana (176632)
- Brkljačić-Kerhin, Vesna (5604)
- Čečuk-Jeličić, Esma
- Kaštelan, Andrija (20432)
Proceedings title: Knjiga postera
Language: engleski
Place: Zagreb
Year: 1995
Pages: from 47 to 50
Meeting: 11th International Antropological Poster Conference
Held: from 06/18/95
Summary: We have analysed the segregation and inheritance of HLA-B27
bearing haplotypes with at least one B27+ patient suffering from ankylosing
spondylitis. Familial segregation of B27 haplotypes has been followed in
103 families undergoing bone-marrow of kidney transplantation (control
group C-1). The statistical significance (p<0,05) was found when ratio
between B27+ males and females in AS group was compared with same ratio in
C-1 group. Paternal inheritance of HLA-B27 has also been analysed in AS
families and 488 families undergoing paternity testing (control group C-2).
In both groups maternal and paternal inheritance was followed in 284 and
maternal in 173 siblings. The most striking highly statistically
significant (p<0,001) when compared with the same mode of inheritance in
the control group. Possible explanations of this unusual inheritance in the
control group. Possible explanations of this unusual inheritance are higher
affinity between oocyte B27+ and y-sperm cell or preferable implantation of
male B27+ zygote versus female B27+ zygote in B27+mother.
Keywords: HLA-B27 antigene, Ankylosing spondylitis, segregation
- Type of paper
: Paper in proceedings
Title:
- Authors:
- Žunec, Renata
- Brkljačić-Šurkalović, Ljerka (5595)
- Dumić, M
- Ille, J
- Brubić, Zorana (176632)
- Humar, Ines (159135)
- Plavšić, V
- Kuvačić, Ivan
- Kaštelan, Andrija (20432)
Proceedings title: Knjiga postera
Language: engleski
Place: Zagreb
Year: 1995
Pages: from 95 to 98
Meeting: 11th International Antropological Poster Conference
Held: from 06/18/95
Summary: The close genetic between the gene for congenital adrenal
hyperplasia (CAH) due to 21-hydroxylase deficiency and HLA-A,B,DR genes
allow us to use the polymorphism of this system as a marker of disease.
Prenatal diagnosis of CAH by HLA typing is based on the fact that all
affected children in a family will be HLA identical. HLA typing on fetal
cells is performed on the amniotic fluid cells grown in vitro. As the
expression of HLA-DR antigens on fetal cells is weak, classical serological
typing only allows the determination of fetal HLA-A,B antigens. In latest
six prenatal diagnosis we have introduced HLA-DR typing on fetal DNA using
PCR-SSP method. In all cases HLA-DR typing was performed successfully,
predicted in one case affected homozygous and in five cases unaffected
carrier. The supplementary use of HLA-DR typing proved helpfull in families
with HLA-B homozygosity and in cases where HLA-A,B typing could not be
performed.
Keywords: PCR-SSP, congenital adrenal hyperplasia, HLA genes
- Type of paper
: Paper in proceedings
Title:
- Authors:
- Žunec, Renata
- Brubić, Zorana (176632)
- Jurčić, Zvonimir
- Dumić, M
- Kadrnka-Lovrenčić, Magda
- Kaštelan, Darko
- Kaštelan, Andrija (20432)
Proceedings title: Knjiga postera
Language: engleski
Place: Zagreb
Year: 1995
Pages: from 99 to 102
Meeting: 11th International Antropological Poster Conference
Held: from 06/18/95
Summary: Susceptibility to several autoimmune disorders such as
IDDM, RA and CD is linked to genes within the major histocompatibility
complex and strong population association are demonstrable between certain
HLA class II in these conditions. PCR-SSO typing combines the ability to
define the subtypes of HLA specifities with possibility of studying large
numbers of normal and affected individuals. In this study we have analysed
HLA-DRB1, DQA1, DQB1 and DPB1 polymorphism in 30 IDDM, 40 RA and 20 CD
patients while 140 healthy Croatians served as a control group. For all
studied diseases an association with HLA class II genes has been found: 1.
IDDM: positive association with DRB1*0301, *04, DQA1*0301, DQB1*0201 and
DQB1*0302; negative association with DQB1*0301 and DPB1*0301 2. RA:
positive association with DRB1*01 and negative association with DRB1*11 3.
CD: positive association with DRB1*0301 DQA1*0501 DQB1*0201 (extended
haplotype). These data clearly define an association of IDDm, RA and CD in
Croatian population with different subtypes of HLA class II genes.
Keywords: PCR-SSO, HLA class II genes, IDDM, RA, CD
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Brubić, Zorana (176632)
- Brkljačić-Kerhin, Vesna (5604)
- Čečuk-Jeličić, Esma
- Kaštelan, Andrija (20432)
Proceedings title: Human Immunology
Language: engleski
Place: Strasbourg, Francuska
Year: 1994
Meeting: European Conference of Histocompatibility 1994
Held: from 03/07/95 to 03/09/95
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Žunec, Renata
- Brubić, Zorana (176632)
- Jurčić, Zvonimir
- Kaštelan, Andrija (20432)
- Editors
- Žunec, Renata
- Brubić, Zorana (176632)
- Jurčić, Zvonimir
- Kaštelan, Andrija (20432)
Proceedings title: European Journal of Immunogenetics
Language: engleski
Place: Aarhus, Danska
Year: 1995
ISBN/ISSN: 0960-7420
Pages: from 61
Meeting: Joint meeting of BSHI and EFI
Held: from 03/08/95 to 03/11/95
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Brubić, Zorana (176632)
- Žunec, Renata
- Kaštelan, Andrija (20432)
Proceedings title: European Journal of Immunogenetics
Language: engleski
Place: Aarhus, Danska
Year: 1995
ISBN/ISSN: 0960-7420
Pages: from 61
Meeting: Joint meeting of BSHI and EFI
Held: from 03/08/95 to 03/11/95
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Žunec, Renata
- Brubić, Zorana (176632)
- Kaštelan, Darko
- Kaštelan, Andrija (20432)
Proceedings title: European Journal of Immunogenetics
Language: engleski
Place: Aarhus, Danska
Year: 1995
ISBN/ISSN: 0960-7420
Pages: from 58
Meeting: Joint meeting of BSHI and EFI
Held: from 03/08/95 to 03/11/95
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Brubić, Zorana (176632)
- Žunec, Renata
- Kaštelan, Andrija (20432)
Proceedings title: European Journal of Immnunogentics
Language: engleski
Place: Aarhus, Danska
Year: 1995
ISBN/ISSN: 0960-7420
Pages: from 124
Meeting: Joint meeting of BSHI and EFI
Held: from 02/08/95 to 03/11/95
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Brubić, Zorana (176632)
- Žunec, Renata
- Kaštelan, Darko
- Kaštelan, Andrija (20432)
Proceedings title: Liječnički vjesnik
Language: hrvatski
Place: Zagreb
Year: 1995
Pages: from 60
Meeting: Prvi hrvatski endokrinološki kongres
Held: from 06/01/95 to 06/04/95
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Žunec, Renata
- Dumić, M
- Ille, J
- Plavšić, V
- Kuvačić, Ivan
- Brkljačić-Šurkalović, Ljerka (5595)
- Brubić, Zorana (176632)
- Tomašković, Marija (92334)
- Kaštelan, Andrija (20432)
Proceedings title: Liječnički Vjesnik
Language: hrvatski
Place: Zagreb
Year: 1995
ISBN/ISSN: 1330-4917
Pages: from 64
Held: from 06/01/95 to 06/04/95
- Type of paper
: M.A.
Title: Relation between infertility and fetus genome in man
Faculty: Prirodoslovno-matematički Zagreb
Date of defense: 11/24/92
Number of pages: 99
- Type of paper
: M.A.
Title: HLA and ankylosing spondylitis. Population and family
studies.
Faculty: Prirodoslovno-matematički Zagreb
Date of defense: 11/27/91
Number of pages: 85
- Type of paper
: Mentorship
Title: Relation between infertility and fetus genome in man
Faculty: Prirodoslovno-matematički Zagreb
Date of defense: 11/24/92
Number of pages: 99
Author: Humar Ines
Degree level: M.A.
- Type of paper
: Mentorship
Title: HLA and ankylosing spondilitys. Population and family
studies.
Faculty: Prirodoslovno-matematički Zagreb
Date of defense: 11/27/91
Number of pages: 85
Author: Brubić Zorana
Degree level: M.A.
- Type of paper
: Manuscript
Title: DNA Typing in the Department of Immunohaematology and
Blood Bank University Hospital Leiden The Netherlands
- Authors:
- Giphart, M
- Drabbels, J
- Verduijn, W
- Brubić, Zorana (176632)
- Naipal, A
- Hanifi, P
