SVIBOR - Project code: 3-01-111

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

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Project code: 3-01-111


INFECTIOUS DISEASES - IMPORTANCE OF IMMUNOLOGICAL PARAMETERS


Main researcher: BUREK, VITOMIR (78330)


Assistants
Type of research: applied
Duration from: 01/01/91. to 12/31/93.
Papers on project (total): 14
Papers on project quoted in Current Contents: 1
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of Infectious Diseases
Address: Mirogojska c.8
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)1 4557-222
Fax: 385 (0)1 425-907
Phone: 385 (0)
Summary: Proposed project comprises research in some of the specific and unspecific immunological parameters in several lines of infectious diseases: viral hepatitis (A,B,D,C,E other non-A, non-B, non-E viruses), acquired immunodeficiency syndrome (AIDS) or generally HIV infection, Lyme borreliosis, pertussis, infections of respiratory and digestive tract, infections with herpes viruses, rubella virus, tick born meningoencephalitis virus and by Toxoplasma g. Analysis of immunomediators like TNF, Interleukin 1, and nearly connected endotoxin, is directed in the first place on patients with meningitis and some other septic conditions, as, untill now, the best defined model for such type of investigation. Precise follow-up and analysis of specific immunologic parameters enables the only possible exact diagnosis in the first two illnesses (viral hepatitis, AIDS - HIV infection) and advances it essentially in other infectious diseases. Detection of presence, dynamics and correlation of immunomediators and endotoxin with clinical picture and prognosis of illness in septic condition and purulent meningitis is in the very beginning, but so far informations indicate their essential role in pathogenesis of illnesses listed above and a possibility of their usefulness in practical purposes.

Keywords: Immunologic Parameters, Viral Hepatitis A,B,D,C,E,non-A,non-B, non-E; AIDS, HIV Infection, Lyme borreliosis, pertussis, immunomediators, tumor necrosis factor, interleukins, endotoxin.

Research goals: The goal of proposed research is to detect: 1. specific andunspecific immunological parameters - antigen/antibody system,subpopulation of T and B lymphocytes, immunomediators; 2. in whatextent immunologic events can give precise characterization of momentarily pathogenic condition of patients, serve as a base forexact diagnosis and if the constellation of these parameters canindicate outcome and prognosis of the disease; 3. in what extentthese parameters can be used as orientation for the beginning oftherapy and evaluation of their efficiency or application ofadequate prophylaxis in prevention of some of above mentionedillnesses. In the field of viral hepatitis the object of intensive researchwill be: simultaneous appearance of HBsAg and anti-HBs, specificimmune complexes, Pre S1 and Pre S2 systems, isolated appearanceof HBsAg with out adequate antibodies (HBV2 virus). Antibodies to HCV and HEV and genetic material of HCV what enables earlydiagnosis and beginning and monitoring of efficiency of hepatitis C therapy. The only possibility of exact determination of contact with HIVis analyisi of immunological markers. Determination of its kinetic may point at the outcome of infect and be a finger-post for thebeginning of therapy before the symptoms of disease becomeevident. Special problems are individuals with undefined resultsof this parameters. The main support in making diagnosis of Lyme disease is theanalysis of specific antibodies. Determination of antibody/antigen enables rapid and exact diagnosis respiratory and digestive tract infections, infections due to herpes viruses, tick born meningoencephalitis virus and infections with Toxoplasma g. Contribution of proposed research has accordingly a scientificand a practical meaning. Scientific contribution consists inprecise determination of condition and dynamics of immunologic parameters in the course of mentioned infectious diseases.Determination of correlation of these elements with clinicalstatus of patient, course of disease, choice and efficiency of therapy and outcome of disease could give very practical contribution.

COOPERATION - INSTITUTIONS


  1. Name of institution: Klinika za infektivne bolesti "Dr. Fran Mihaljević"
    Type of institution: International organization
    City: 10000 - Zagreb, Croatia

  2. Name of institution: Max Von Pettenkofer Institut
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Muenchen, Njemačka

  3. Name of institution: Biomedical Research Center, IMMUNO
    Type of cooperation: Joint publishing of scientific papers
    City: Wien, Austria
Other information about the project.
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