SVIBOR - Project code: 3-01-125


Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69


SVIBOR - Collecting Data on Projects in Croatia

Project code: 3-01-125


Main researcher: GRCE, MAGDALENA (138731)

Type of research: applied
Duration from: 10/05/91. to 12/31/95.

Papers on project (total): 12
Papers on project quoted in Current Contents: 5
Institution name: Zavod za zaštitu zdravlja Republike Hrvatske, Zagreb (5)
Department/Institute: Division of Molecular Medicine Department of Biology and Medicine RuĐer Bošković Institute
Address: Bijenička cesta 54
City: 10000 - Zagreb, Croatia
Phone: 385 (01) 4561-110
Fax: 385 (01) 424-239,425-497

Summary: The prevalence of STD due to the intracellular infectious agentslike C.trachomatis, herpes viruses, human papillomaviruses, humanimmunodeficiency virus, is rapidly increasing for the past 30years, while the prevalence of the bacterial STD is decreasing.These agents, regarded as the second generation of STD, arefrequently more difficult to identify, treat and control and,unfortunatelly, are causing serious complicatons which result inchronic ill-health, disability and death. The investigation ofC.trachomatis, CMV, HSV and HPV in young women and there partnerswould determinde there incidence, there correlation with eachother and with problems of infertility and carcinogenesis. In the world, WHO estimates that there are some 250 million new cases of STD each years. Among those, there are some 50 million cases of genital chlamydia, 30 million cases of genital papillomavirus and 20 million cases of genital herpes. There is an urgent need in all countries to establish an adequate system for the prevention, diagnosis and treatment of STDs. From 1990 to 1993, 600 young women and partly there partners were analysed for the presence of 3 to 4 infections agents from the second generation STD. Most subjects had one of them. Cases of coinfections and common infections in both partners were observed. The statistical analysis of the laboratory results and the correlation with clinical picture was presented on several conferences in Croatia and abroad and will be published.

Keywords: Sexually transmitted diseases (STD),Chlamydia trachomatis (C.trachomatis),cytomegalovirus (CMV),herpes simplex virus (HSV), human papillomavirus (HPV)

Research goals: The aim of this study is to propose the best model of control and prevention of the second generation STD. It consists in the improvement of the method of identification of infections agents, especially for the detection of HPV genome by the method of hybridization and polymerase chain reaction as a preventive strategy of cervical cancer. The main problem of the whole project was to develop a reliable and reproducible molecular technique for HPV detection. The effort were concentrated on the dinstinction between high risk HPVs (16, 18) from low risk HPVs (6, 11).


  1. Name of project: 1-08-144 Ekspresija i uloga onkogena i faktora rasta u malignim tumorima
    Name of institution: Institut "Ruđer Bošković", Zavod za molekularnu medicinu
    City: 10000 - Zagreb, Croatia


  1. Name of institution: Hrvatski Zavod za javno zdravstvo
    Type of institution: State institute
    Type of cooperation: Occasional exchange of information
    City: 10000 - Zagreb, Croatia

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Last update: 12/14/94