SVIBOR - Project code: 3-01-138

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

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Project code: 3-01-138


METALS IN THE ENVIRONMENT AND THEIR HEALTH IMPACTS


Main researcher: MOMČILOVIĆ, BERISLAV (32360)


Assistants
Type of research: basic
Duration from: 01/01/91. to 12/31/94.
Papers on project (total): 232
Papers on project quoted in Current Contents: 64
Institution name: Institut za medicinska istraživanja i medicinu rada, Zagreb (22)
Department/Institute: Lab. Physiol. Min. Metabol., Lab. Anal. Phys. Chem., Clin. Toxicol. Lab., Dept. Occup. Medicine
Address: Ksaverska c. 2
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0) 1 434 188
E-mail: blanusa@mimi.imi.hr
Fax: 385 (0) 1 274 572
Summary: Within this project the following analytical, physic-chemical and biomedical studies on various aspects of metal impact on health have been performed in the past four and half year period: - development of analytical methods for determination of metals (Pb, Cd, Hg, Al and Se); - monitoring of toxic metals in environmental and human biological matrices; - the molecular-mechanical conformational analysis, spectroscopic and potentiometric research on copper complexes; experimental studies on rats on new therapy for reducing the body burden of lead, cadmium and mercury; - experimental studies on reproductive and perinatal effects of lead and cadmium; - experimental studies on influence of cadmium on transport mechanisms in cellular membranes; - human studies on evaluation of biological indicators in environmentally exposed sensitive populations (women and children); - reproductive effects of lead and cadmium in men; - kidney function of occupationally exposed population to lead; - influence of diet on lead absorption. The results of this project have been published in: 78 papers in scientific journals (63 cited in CC), edited one book, 7 chapters in books, 37 scientific papers in congress proceedings (28 international and 9 national), 82 abstracts from various meetings, 4 Ph.D. Theses and 4 M.Sc. Theses.

Keywords: differential pulse anodic stripping voltammetry, atomic absorption spectrometry, conformational analysis of copper complexes, monoalkyl esters of DMSA, N-(4-methoxybenzyl)-D-glucamine-N-carbodithioate (MeOBDCG), reproduction, experimental studies in rats; kidney brush border membranes, epidemiology, biological monitoring, neuropsychological effect, hemopoiesis, women, children, lead, cadmium, mercury, selenium, zinc, copper, iron, aluminium

Research goals: The aim of this project was to evaluate the extent of exposure of our population to metal contaminants in the environment, to evaluate adequate biological indicators of exposure and to estimate possible health effect. This goal was approached from different aspects; analytical - set up or improvement of methods for various metal analysis in different biological and environmental matrices; basic physicochemical approach - study on structure of metal-organic ligand complexes; experimental approach - reproduction studies, testing of new chelators for reducing body burden of metals, study of carcinogenic and mutagenic effect of chromium and nikl, introduction of new biochemical approach to study toxic effect of metals in kidney brush border membranes and epidemiological approach - studies of different segments of normal or occupationally exposed populations.

COOPERATION - PROJECTS


  1. Name of project: 3-01-131 OCJENA UKUPNE IZLOŽENOSTI LJUDI ONEČIŠĆENJIMA U OKOLINI
    Name of institution: Institut za medicinska istraživanja i medicinu rada
    City: 10000 - Zagreb, Croatia

  2. Name of project: LH-378/ILZRO The Effect of Lead on the Reproduction Ability in Men
    Name of institution: International Lead and Zinc Research Organization (ILZRO)
    City: Research Triangle Park,NC, SAD

  3. Name of project: RO3 TW00512-01A1 Isolation and characterization of kidney endosomes
    Name of institution: National Institute of Health, Fogarty International Centre, Bethesda
    City: Bethesda, Maryland, USA

  4. Name of project: CRO.6230 Chelation Therapy of Important Toxic Metals
    Name of institution: International Atomic Energy Agency
    City: Beč, Austrija

COOPERATION - INSTITUTIONS


  1. Name of institution: Rowett Research Institute
    Type of institution: University/Faculty
    City: Aberdeen, Velika Britanija

  2. Name of institution: Vanderbilt University
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Nashville, Tennessee, SAD

  3. Name of institution: Grand Forks Human Nutrition Research Centre
    Type of institution: University/Faculty
    City: Grand Forks, ND, SAD

  4. Name of institution: Nelson Institute of Environmental Medicine, New York University Medical Center
    Type of institution: University/Faculty
    City: Tuxedo, NY, SAD

  5. Name of institution: US Environmental Protection Agency, Reproductive Toxicology Branch, Health Effects Research Laboratory
    Type of institution: University/Faculty
    City: Research Triangle Park,NC, SAD

  6. Name of institution: International Lead Zinc Research Organization (ILZRO)
    Type of institution: International organization
    Type of cooperation: Joint project
    City: Research Triangle Park,NC, SAD

  7. Name of institution: Institut "Ruđer Bošković"
    Type of institution: State institute
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  8. Name of institution: Zavod za anorgansku kemiju Prirodoslovno-matematičkog fakulteta
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  9. Name of institution: University of Arkansas, College of Pharmacy
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Arkansas, SAD

  10. Name of institution: The Technical University of Denmark
    Type of institution: University/Faculty
    Type of cooperation: Joint project
    City: Lyngby, Danska

  11. Name of institution: Center for Mechanistic Biology & Biotechnology, Argonne National Laboratory
    Type of cooperation: Joint project
    City: 60439-4833 - Argonne, Illinois, USA

  12. Name of institution: Massachusetts General Hospital and Harvard Medical Scool
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Boston, Massachussets, USA

  13. Name of institution: Institut fuer Physiologie und Pathophysiologie, Georg-August-Universitaet Goettingen
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Gottingen, Njemačka

  14. Name of institution: Physiologisches Institut der Universitaet Zuerich
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Zuerich, Švicarska

  15. Name of institution: Veterans Affairs Medical Centre, Medical College of Wisconsin, University of Wisconsin
    Type of cooperation: Joint publishing of scientific papers
    City: Milwaukee, Wisconsin, USA

  16. Name of institution: II Physiologisches Institut der Universitaet Saarlandes
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Homburg/Saar, Njemačka
Other information about the project.
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Last update: 10/16/95
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