SVIBOR - Project code: 3-01-144

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

SVIBOR - Collecting Data on Projects in Croatia

Project code: 3-01-144


INVESTIGATION OF ADVERSELY FACTORS IN HUMAN REPRODUCTION


Main researcher: SINGER, ZVONIMIR (90713)


Assistants
Type of research: basic
Duration from: 01/31/91. to 12/31/94.
Papers on project (total): 32
Papers on project quoted in Current Contents: 9
Institution name: Bolnica "Merkur", Zagreb (44)
Department/Institute: Department of Obstatrics and Gynaecology
Address: Zajčeva 19
City: 10000 - Zagreb, Croatia
Communication
Summary: Couples with habitual miscarriages have been investigated in aprospective study covering the period 1991-1994. Diagnosticscreening, observation and monitoring were carried out as well asapplication of preventive measures. In our research work we madeuse of clinical, genetic, microbiological, ultrasound,endocrinologic and immunogentic methods. In the investigationsconducted so far, possible causes of infertility were discoveredin 88% of all cases, while 12% remained unexplained. A prognosisof infertility is possible to make on the basis of detection ofexternal and unfavourable hereditary factors. Only then does itbecome possible to organize primary and secundary preventivemeasures.

Keywords: adversely genetic and enviromental factors, human reproduction, cytogenetic analysis, karyotype, prenatal diagnosis, ultrasound diagnosis

Research goals: Possibility of increasing the scientific competency is given through examination of etiopathogenesis of infertility as well as improvement of diagnostics competence. In that way it enables us to follow achievments and results in the entire world and to transfer the world's kvnowledge in cooperation with scientifically developped countries. Even the last investigations in some fields such as chorion frondosum put us in about ten of the most advanced groups which enable us to be included adequately in exchanging experiences. With high risk couples in which reccurency of unfavourable course of pragnancy is present, investigations will make possible identification of continuously present genetic and/or external unfavourable factors. Prevention can be possible by elimination of teratogenic factors or as secundary prevention by prenatal diagnostics of hereditary diseases (chromosomopathia and genopathia). The proposed investigations in our population would present organized team-work on all recent levels including possible personal as well as technical solutions on each investigated level.

COOPERATION - INSTITUTIONS


  1. Name of institution: Centar za tipizaciju tkiva KBC Rebro
    Type of institution: University/Faculty
    City: 10000 - Zagreb, Croatia

  2. Name of institution: Imunološki Zavod
    Type of institution: University/Faculty
    City: 10000 - Zagreb, Croatia

  3. Name of institution: Labor fur Gynaekologishe Zytologie an der Frauenklinik Kantonsspital. Institut fur Patologie an der Universitet Basel
    Type of institution: University/Faculty
    City: Basel

  4. Name of institution: Department of Obstetrics and Gynaecology, Kings College Hospital, London, UK
    Type of institution: University/Faculty
    City: London
Other information about the project.
MZT Croatian language SVIBOR Alphabetic list Sorted on project code Sorted on institutions Search help
Ministry of
Science and
Technology		 Croatian
language		 Svibor
homepage		 Alphabetic
list		 Sorted on
project code		 Sorted on
institutions		 Search Help
Last update: 01/20/94
Information: svibor@znanost.hr