- Type of paper
: Book
Title:
- Authors:
- Flory, E.
- Stuhler, A.
- Editors
- Frey, A.
- Brohm, T.
- Barac-Latas, Vesna (142193)
- Lassmann, H.
- Wege, H.
Publisher: M. Schwyzer, M. Ackermann, G. Bertoni et al.
Year: 1995
Number of pages: 5
Number of references: 21
Language: engleski
Keywords: coronavirus infection, demyelination, vaccination, apoptosis of oligodendrocytes.
- Type of paper
: Book
Title:
- Authors:
- Stuhler, A.
- Flory, E.
- Barac-Latas, Vesna (142193)
- Lassmann, H.
- Wege, H.
Publisher: M. Schwyzer, M. Ackermann, G. Bertoni et al.
Year: 1995
Number of pages: 5
Number of references: 12
Language: engleski
Summary: The surface glycoprotein S (spike) of coronaviruses in a
major determinant for virulence and displays great phenotypic variability
among different strains and variants. Here we addressed the question,
whether this variability is reflected by a heterogeneous
quasispecies-distribution of mutated RNA-molecules within the infected
organ. As a model, we analyzed the variability of S-gene sequence directly
in brain tissue from rats persistently infected with murine coronavirus.
Our results indicate, that in vivo-at least under the constraints of a
persistent infection-the S-protein sequence appears to be relatively
conserved.
Keywords: coronavirus infection, demyelination, variability of S gene of mouse-hepatitis-virus MHV-JHM
- Type of paper
: Paper in journal
Title: Immunomodulation by somatostatin
- Authors:
- Radošević-Stašić, Biserka (39764)
- Ćuk, Mira (85006)
- Rukavina, Daniel (41705)
Journal: Period. Biol.
Number: 1
ISSN: 0031-5362
Volume: 93
Year: 1991
Pages: from 131 to 139
Number of references: 73
Language: engleski
Summary: Much evidence shows that somatostatin plays a significant
role inthe circuit that exists between the neuroendocrine and immunesystem.
Its mostly immunosuppressive effects may be related toits capacity: 1) to
modulate the release and action of variousneurotransmitters, hormones and
cytokines which affect thelymphatic functions; 2) to act directly on
receptors oflymphocytes and other cells participating in immune
response,and/or 3) to change the other events related to the function
oflymphatic organs such as blood flow, vascular permeability orlymphocyte
traffic. Its widespread localization andmultispecifity of action emphasize
its importance for themaintenance of neuro-endocrino-immune homeostasis.
Keywords: Somatostatin, SMS 201-995, immunosuppression, neuroimmunoendocrinology.
- Type of paper
: Paper in journal
Title:
- Authors:
- Morović, Miro (66165)
- Haller, Herman (146311)
- Rukavina, Daniel (41705)
- Dujella, Josip
- Sepčić, Juraj (64815)
- Ledić, Darko (142003)
- Barac-Latas, Vesna (142193)
Journal: Period. biol.
Number: 3
ISSN: 0031-5362
Volume: 93
Year: 1991
Pages: from 405 to 409
Number of references: 23
Language: engleski
Summary: Juvenile DA and F1 hybrid rats (AOxDA) were immunized with
bovinebrain white matter in complete Freund's adjuvant to produce
therelapsing form of experimental allergic encephalomyelitis(R-EAE).
Recovery from actively induced disease resulted in adifferent rate of
susceptibility to active reinduction of diseasein these high susceptible
rats. Hydrids F1 (AOxDA) developedrelative resistance, while DA rats were
completely resistant toactive reinduction of disease. The treatment
withcyclophosphamide (20 mg/kg), administered 2 days beforereimmunizaion,
inhibited the resistance to EAE reinductionobserved in DA rats, and
increased the susceptibility to EAEreinduction in F1 hybdids. Rats which
were splenectomized 12 daysbefore the initial immunization were higly
susceptible to activeEAE reinduction. However, when splenectomy was
performed 4 daysafter encephalitogenic challenge (i.e. during the induction
phaseof disease), significantly lower susceptibility to active
EAEreinduction was observed. These results suggest that low
dosecyclophosphamide sensitive (suppressor) cells and spleendependent
suppressor activity could directly mediate themechanisms of acquiring
resistance to active disease reinduction.
Keywords: Relapsing form of experimental allergic encephalomyelitis (R-EAE), susceptible strains of rats: DA and F1 (AOxDA), reinduction of R-EAE, cyclophosphamide and spleen-dependent suppressor cells , resistance to reinduction of EAE.
- Type of paper
: Paper in journal
Title:
- Authors:
- Morović, Miro (66165)
- Haller, Herman (146311)
- Rukavina, Daniel (41705)
- Dujella, Josip
- Sepčić, Juraj (64815)
- Barac-Latas, Vesna (142193)
Journal: Acta Fac. med. Flum.
Number: 3 4
ISSN: 0065-1206
Volume: 16
Year: 1991
Pages: from 99 to 107
Number of references: 29
Language: engleski
Summary: Experimental allergic encephalomyelitis (EAE) was induced
in ratsof various genotypes by active immunization with anencephalitogenic
bovine brain extract. Chronic relapsing clinicaldisease was noted in
juvenile F1 progeny of AO males and DAfemales in a high percentage of
animals (65-75%), while in DAstrain it was only 20-25%. Here, a summary
ofclinicopathological, genetical and immunological analyses isdecribed. The
results corfirm: 1) the close similarities inmorphology of CNS lesions in
CR-EAE and multiple sclerosis, 2)the essential role of cell-mediated
immunity in the pathogenesisof EAE, 3) the fact that EAE susceptibility is
a genetic traitand 4) the existence of a defective systemic immune
regulation inCR-EAE.
Keywords: Experimental allergic encephalomyelitis, AOxDA rats.
- Type of paper
: Paper in journal
Title:
- Authors:
- Lučin, Pero (142314)
- Polić, Bojan (173636)
- Crnković, Irena (194586)
- Lučin, Ksenija (142235)
- Rukavina, Daniel (41705)
- Jonjić, Stipan (95983)
Journal: Croatian Med. J.
Number: 1
Volume: 33
Year: 1992
Pages: from 9 to 16
Number of references: 26
Language: engleski
Summary: Treatment with monoclonal antibodies to CD4 and a
combinationof mAb to CD4 and CD8, in addition to streptozotocin (45mg/kg)
prevented the development of hyperglycemia onlypartially and temporarily.
Similar consequences were seen afterthe treatment with silica.
Keywords: Diabetes, streptozotocin, T lymphocytes, macrophages.
- Type of paper
: Paper in journal
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Petković, Marija (133654)
- Milin-Knafel, Čedomila (70123)
- Verbanac, Donatella (133213)
- Muhvić, Damir (151520)
- Barac-Latas, Vesna (142193)
- Ćuk, Mira (85006)
- Rukavina, Daniel (41705)
Journal: Advances in Pineal Research
ISSN: 0269-0071
Volume: 7
Year: 1993
Pages: from 157 to 165
Number of references: 21
Language: engleski
Summary: The effects of pharmacological pinealectomy (Px) on
liverregeneration and lymphatic morphostasis were studied in ratstreated by
evening injections of propranolol. The data have shownthat Px might inhibit
the early phase of liver growth and expression of class II antigens in
regenerating tissue. Theseeffects were followed by marked changes in the
spleen (in theproportion of CD4, CD8, OX-33, OX-42, Mac-1 and Mac-3+
cells).Some of these effects might be reversed by melatonin.
Keywords: Pharmacological pinealectomy, propranolol, melatonin, regenerating liver, partial hepatectomy, hepatic expression of class II antigens, phenotype of cells in spleen.
- Type of paper
: Paper in journal
Title:
- Authors:
- Verbanac, Donatella (133213)
Journal: FEBS
Number: 3
Volume: 317
Year: 1993
Pages: from 255 to 258
Number of references: 24
Language: engleski
Summary: In the present study were studied the biological activities
ofthe immature forms of two peptide, isolated from
activatedneutrophils-proBac5 and proBac7. The data have shown that
proBac7is a monocyte-selective chemoattractant, while proBac5 is
anefficient inhibitor of cathepsin L, a cysteine proteinase,
whichcontributes to local tissue injury.
Keywords: Antibiotic peptide precursors, Bac7, Bac5, activated neutrophiles, monocyte-selective chemoattractant, cathepsin L activity, local tissue inflammation.
- Type of paper
: Paper in journal
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Trobonjača, Zlatko (173625)
- Lučin, Pero (142314)
- Ćuk, Mira (85006)
- Polić, Bojan (173636)
- Rukavina, Daniel (41705)
Journal: Intern. J. Neuroscience
Volume: 81
Year: 1995
Pages: from 283-2 to 97
Number of references: 37
Language: engleski
Summary: The effects of long acting aomatostatin analog SMS 201-995
were examined in vivo on: Lymphoid morphostasis and functional reactivity
of cells obtained from SMS treated donors, on humoral, and cellular type of
immunity, and in vitro on blastic transformation of lymphocytes stimulated
by activators of different transmembrane pathways (CD2 by PHA and CD#/TRC
by anti-CD3 monoclonal antibody and by allogeneic cells) and on growth and
secretory activity of several hybridoma cell lines. The data have shown
that SMS in vivo decreases the proportion of CD4,CD5 and Ig+ cells in
spleen. The reactivity of these cells to Con A was suppressed, but their
spontaneous blastic transformation was increased. SMS suppressed also the
PFC generation and proliferation of cells in popliteal lymph nodes during
the local host versus graft reaction. The data obtained in vitro revealed
that SMS may inhibit only CD2-induced blastogenesis (in early and late
interval after the use of PHA). SMS inhibited also the spontaneous growth
and/or secretion of antibodies in some hybridoma cell lines.
Keywords: SMS 201-995, immunosuppression, CD2 and CD3/TRC-dependent blastogenesis, growth of hybridoma cell lines.
- Type of paper
: Paper in proceedings
Title:
- Authors:
- Milin-Knafel, Čedomila (70123)
- Verbanac, Donatella (133213)
- Ćuk, Mira (85006)
- Dvornik, Štefica (176834)
- Trobonjača, Zlatko (173625)
- Radošević-Stašić, Biserka (39764)
Proceedings title: Pharmacological communications
Language: engleski
Place: Zagreb
Year: 1993
Pages: from 229 to 231
Meeting: First Croatian Cogress of Pharmacology
Held: from 10/06/93 to 10/08/93
Summary: Prolonged administration of SMS 201-995 to mice, sensitized
withsheep red blood cells was followed by changes in theconcentration of
hepatic nucleic acids and proteins, as well asby changes in blood
composition (proteins, urea, AST, ALT). Someof these effects might be
abrogated by substitution with growthhormone.
Keywords: SMS 201-995, hepatic proteins and nucleis acids, plasmatic concentrations of proteins, urea, AST, ALT, substitution with growth hormone.
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Stašić, Josip (182785)
- Pugel, Ester (133643)
- Jonjić, Nives (84573)
- Sabolić, Josip (85436)
- Radošević-Stašić, Biserka (39764)
- Rukavina, Daniel (41705)
Proceedings title: Apstrakti VIII Kongresa kancerologa Jugoslavije
Language: hrvatski
Place: Zagreb
Year: 1991
Meeting: VIII Kongres kancerologa Jugoslavije
Held: from 05/09/91 to 05/11/91
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Milin-Knafel, Čedomila (70123)
- Verbanac, Donatella (133213)
- Ćuk, Mira (85006)
- Trobonjača, Zlatko (173625)
- Kirigin, Mladena (71782)
- Rukavina, Daniel (41705)
Proceedings title: Abstracts
Language: engleski
Place: Jeruzalem, Israel
Year: 1991
Pages: from 236 to 236
Meeting: 15th International Congress of Biochemistry
Held: from 08/04/91 to 08/08/91
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Milin-Knafel, Čedomila (70123)
- Radošević-Stašić, Biserka (39764)
- Verbanac, Donatella (133213)
- Ćuk, Mira (85006)
- Dvornik, Štefica (176834)
- Trobonjača, Zlatko (173625)
- Rukavina, Daniel (41705)
Proceedings title: Abstracts
Language: engleski
Place: Jeruzalem, Israel
Year: 1991
ISBN/ISSN: .
Pages: from 371 to 371
Meeting: 15th International Congress of Biochemistry
Held: from 08/04/91 to 08/08/91
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Ćuk, Mira (85006)
- Trobonjača, Zlatko (173625)
- Lučin, Pero (142314)
- Muhvić, Damir (151520)
- Polić, Bojan (173636)
- Efendić, Suad
- Rukavina, Daniel (41705)
Proceedings title: Abstracts
Language: engleski
Place: Jeruzalem, Israel
Year: 1991
ISBN/ISSN: .
Meeting: Third International Congress of the International Society of Neuroimmunology
Held: from 10/27/91 to 11/01/91
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Trobonjača, Zlatko (173625)
- Ćuk, Mira (85006)
- Petković, Marija (133654)
- Barac-Latas, Vesna (142193)
- Mrakovčić-Šutić, Ines (146280)
- Muhvić, Damir (151520)
- Ravlić-Gulan, Jagoda (194632)
- Efendić, Suad
- Rukavina, Daniel (41705)
Proceedings title: Abstracts
Language: engleski
Place: Budapest, Mađarska
Year: 1992
Pages: from 253 to 254
Held: from 08/23/92 to 08/28/92
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Trobonjača, Zlatko (173625)
- Radošević-Stašić, Biserka (39764)
- Ćuk, Mira (85006)
- Petković, Marija (133654)
- Barac-Latas, Vesna (142193)
- Mrakovčić-Šutić, Ines (146280)
- Muhvić, Damir (151520)
- Ravlić-Gulan, Jagoda (194632)
- Rukavina, Daniel (41705)
Proceedings title: Abstracts
Language: engleski
Place: Budapest, Mađarska
Year: 1992
Pages: from 583 to 584
Meeting: 8th International Congress of Immunology
Held: from 08/23/92 to 08/28/92
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Trobonjača, Zlatko (173625)
- Ćuk, Mira (85006)
- Petković, Marija (133654)
- Barac-Latas, Vesna (142193)
- Mrakovčić-Šutić, Ines (146280)
- Ravlić-Gulan, Jagoda (194632)
- Muhvić, Damir (151520)
- Milin-Knafel, Čedomila (70123)
- Rukavina, Daniel (41705)
Proceedings title: Advances in psychoneuroimmunology
Language: engleski
Place: Budapest, Mađarska
Year: 1992
Pages: from 58 to 59
Meeting: Hans Selye Symposia in Neuroendocrinology
Held: from 08/17/92 to 08/21/92
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Trobonjača, Zlatko (173625)
- Radošević-Stašić, Biserka (39764)
- Ćuk, Mira (85006)
- Petković, Marija (133654)
- Barac-Latas, Vesna (142193)
- Mrakovčić-Šutić, Ines (146280)
- Muhvić, Damir (151520)
- Ravlić-Gulan, Jagoda (194632)
- Efendić, Suad
- Rukavina, Daniel (41705)
Proceedings title: Advances in psychoneuroimmunology
Language: engleski
Place: Budapest, Mađarska
Year: 1992
Pages: from 77 to 78
Meeting: Hans Selye Symposia in Neuroendocrinology
Held: from 08/17/92 to 08/21/92
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Petković, Marija (133654)
- Radošević-Stašić, Biserka (39764)
- Milin-Knafel, Čedomila (70123)
- Trobonjača, Zlatko (173625)
- Ćuk, Mira (85006)
- Ravlić-Gulan, Jagoda (194632)
- Verbanac, Donatella (133213)
- Barac-Latas, Vesna (142193)
- Muhvić, Damir (151520)
- Mrakovčić-Šutić, Ines (146280)
- Rukavina, Daniel (41705)
Proceedings title: Advances in psychoneuroimmunology
Language: engleski
Place: Budapest, Mađarska
Year: 1992
Pages: from 55 to 55
Meeting: Hans Selye Symposia in Neuroendocrinology
Held: from 08/17/92 to 08/21/92
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Muhvić, Damir (151520)
- Petković, Marija (133654)
- Radošević-Stašić, Biserka (39764)
- Rukavina, Daniel (41705)
- Efendić, Suad
Proceedings title: Advances in psychoneuroimmunology
Language: engleski
Place: Budapest, Mađarska
Year: 1992
Pages: from 49 to 49
Meeting: 8th International Congress of Immunology
Held: from 08/17/92 to 08/21/92
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Petković, Marija (133654)
- Trobonjača, Zlatko (173625)
- Trobonjača, Zlatko (173625)
- Ravlić-Gulan, Jagoda (194632)
- Muhvić, Damir (151520)
- Ćuk, Mira (85006)
- Rukavina, Daniel (41705)
Proceedings title: The pineal gland in relation with the immune system and cancer
Language: engleski
Place: Locarno, Švicarska
Year: 1993
Pages: from 33 to 34
Meeting: 1st Locarno International Meeting on Neuroendocrinoimmunology
Held: from 05/02/93 to 05/05/93
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Petković, Marija (133654)
- Trobonjača, Zlatko (173625)
- Milin-Knafel, Čedomila (70123)
- Verbanac, Donatella (133213)
- Muhvić, Damir (151520)
- Ravlić-Gulan, Jagoda (194632)
- Barac-Latas, Vesna (142193)
- Ćuk, Mira (85006)
- Rukavina, Daniel (41705)
Proceedings title: Abstracts
Language: engleski
Place: Paestum (Salerno), Italija
Year: 1993
Pages: from 340 to 340
Meeting: 2nd International Congress ISNIM
Held: from 07/12/93 to 07/17/93
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Milin-Knafel, Čedomila (70123)
- Verbanac, Donatella (133213)
- Trobonjača, Zlatko (173625)
- Ćuk, Mira (85006)
- Radošević-Stašić, Biserka (39764)
Proceedings title: Abstracts
Language: engleski
Place: Zagreb
Year: 1993
Meeting: Annual Meeting of Croatian Biochemistry
Held: from 06/17/93 to 06/18/93
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Trobonjača, Zlatko (173625)
- Muhvić, Damir (151520)
- Ravlić-Gulan, Jagoda (194632)
- Petković, Marija (133654)
- Ćuk, Mira (85006)
- Efendić, Suad
- Rukavina, Daniel (41705)
Proceedings title: Abstracts
Language: engleski
Place: Graz, Austrija
Year: 1993
Pages: from 35 to 36
Meeting: Jahrestagung der osterreichishen gesellschaft fur allergologie und immunologie
Held: from 11/18/93 to 11/20/93
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Petković, Marija (133654)
- Trobonjača, Zlatko (173625)
- Milin-Knafel, Čedomila (70123)
- Verbanac, Donatella (133213)
- Ćuk, Mira (85006)
- Muhvić, Damir (151520)
- Ravlić-Gulan, Jagoda (194632)
- Rukavina, Daniel (41705)
Proceedings title: Period. biol.
Language: engleski
Place: Opatija
Year: 1994
Pages: from 259 to 259
Meeting: Mechanisms in local immunity 2nd ALPS-ADRIA immunol. Allergol. Meeting
Held: from 09/26/94 to 09/28/94
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Muhvić, Damir (151520)
- Petković, Marija (133654)
- Radošević-Stašić, Biserka (39764)
- Rukavina, Daniel (41705)
Proceedings title: Period. biol.
Language: engleski
Place: Zagreb
Year: 1993
Pages: from 271 to 271
Meeting: Mechanisms in local immunity 2nd ALPS-ADRIA immunol. Allergol. Meeting
Held: from 09/26/94 to 09/28/94
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Ravlić-Gulan, Jagoda (194632)
- Trobonjača, Zlatko (173625)
- Petković, Marija (133654)
- Muhvić, Damir (151520)
- Barac-Latas, Vesna (142193)
- Radošević-Stašić, Biserka (39764)
- Rukavina, Daniel (41705)
Proceedings title: Period. biol.
Language: engleski
Place: Zagreb
Year: 1994
Pages: from 285 to 285
Meeting: Mechanisms in local immunity 2nd ALPS-ADRIA immunol. Allergol. Meeting
Held: from 09/26/94 to 09/28/94
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Trobonjača, Zlatko (173625)
- Radošević-Stašić, Biserka (39764)
- Ravlić-Gulan, Jagoda (194632)
- Rukavina, Daniel (41705)
- Efendić, Suad
Proceedings title: Period. biol.
Language: engleski
Place: Zagreb
Year: 1994
Pages: from 285 to 285
Meeting: Mechanisms in local immunity 2nd ALPS-ADRIA immunol. Allergol. Meeting
Held: from 09/26/94 to 09/28/94
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Petković, Marija (133654)
- Ćuk, Mira (85006)
- Trobonjača, Zlatko (173625)
- Radošević-Stašić, Biserka (39764)
- Milin-Knafel, Čedomila (70123)
- Muhvić, Damir (151520)
- Ravlić-Gulan, Jagoda (194632)
- Barac-Latas, Vesna (142193)
- Maestroni, George
Proceedings title: Period. biol.
Language: engleski
Place: Zagreb
Year: 1994
ISBN/ISSN: .
Pages: from 285 to 285
Meeting: Mechanisms in local immunity 2nd ALPS-ADRIA immunol. Allergol. Meeting
Held: from 09/28/94 to 09/28/94
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Milin-Knafel, Čedomila (70123)
- Verbanac, Donatella (133213)
- Domitrović, Robert
- Petković, Marija (133654)
- Ćuk, Mira (85006)
- Varljen, Jadranka
- Radošević-Stašić, Biserka (39764)
Year: 1994
Meeting: Godišnji sastanak Hrvatskih biokemičara
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Trobonjača, Zlatko (173625)
- Radošević-Stašić, Biserka (39764)
- Ravlić-Gulan, Jagoda (194632)
- Rukavina, Daniel (41705)
- Efendić, Suad
Proceedings title: Jahrestagung der Osterreichischen gesellschaft fur allergologie und immunologie
Language: engleski
Place: Beč, Austria
Year: 1994
Meeting: Jahrestagung der osterreichishen gesellschaft fur allergologie und immunologie
Held: from 11/24/94 to 11/26/94
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Trobonjača, Zlatko (173625)
- Muhvić, Damir (151520)
- Ravlić-Gulan, Jagoda (194632)
- Petković, Marija (133654)
- Efendić, Suad
- Rukavina, Daniel (41705)
Proceedings title: Liječnički vjesnik
Language: hrvatski
Place: Zagreb
Year: 1995
Pages: from 93 to 94
Meeting: Prvi hrvatski endokrinološki kongres
Held: from 06/01/95 to 06/04/95
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Petković, Marija (133654)
- Radošević-Stašić, Biserka (39764)
- Trobonjača, Zlatko (173625)
- Ćuk, Mira (85006)
- Milin-Knafel, Čedomila (70123)
- Ravlić-Gulan, Jagoda (194632)
- Rukavina, Daniel (41705)
Proceedings title: Liječnički vjesnik
Language: hrvatski
Place: Zagreb
Year: 1995
Pages: from 96 to 97
Meeting: Prvi hrvatski endokrinološki kongres
Held: from 06/01/95 to 06/04/95
- Type of paper
: Prototype
Title: The use of peptidoglycan monomer (PGM) and its N-acyl
derivates for the preparation of drugs, able to correct the
immunosuppressive and hepatosuppressive conditions in organism
- Authors:
- Radošević-Stašić, Biserka (39764)
- Rukavina, Daniel (41705)
Institution of application: Državni zavod za patente Republike Hrvatske
Date of application: 09/25/92
Registration number of application: P920488A
Countries in which it is protected: Hrvatska
Language: engleski
Summary: Patent is related to the use of peptidoglycan monomer and
itsN-acyl derivates as drug for the correction of immunosuppressionand
hepatosuppression, induced by halothane anaesthesia,operative stress and
similar factors.
Keywords: Peptidoglycan monomer and its N-acyl derivates, immunosuppression, hepatosuppression, halothane anaesthesia, operative stress.
- Type of paper
: Ph.D.
Title: Regeneration of hepatic and lymphatic tissue after the
depletion of T lymphocyte subpopulations
Faculty: Medicinski Fakultet u Rijeci
Author: PETKOVIĆ MARIJA
Date of defense: 12/27/93
Language: hrvatski
Number of pages: 111
Summary: The aim of this work was to establish: 1) the features of
thecompensatory liver growth, after partial hepatectomy (pHx), 2)the
effects of in vivo depletion of CD4, CD8 and CD4+CD8lymphocytes on the
processes of liver regeneration and 3) theeffects of pHx on the spontaneous
repopulation of lymphatictissue in depleted animals. The data have shown
that pHxincreases the expression of MHC class II antigens in
theregenerating liver and induces a marked changes in lymphaticmorphostasis
(phenotypic changes in spleen, hiperplasia in bonemarrow, appearance of
autoantibodies in sera).It seems that someof Hx-induced cells perform the
morfogenetic function, becauseafter the depletion of CD8+ lymphocytes an
increase in hepaticRNA and proteins was noticed, while after the depletion
ofCD4+CD8+ lymphocytes an earlier accumulation of hepatic proteinsoccured.
During the time when the liver regeneration has stoped,an increase of CD8+
lymphocytes in spleen, and in titer ofanti-DNA antibodies in sera were
noticed. Taked together, thedata point to the role of lymphatic cells in
the control ofnormal growth and to the hepatic origin of substances
thatcontrol the lymphatic morphostasis.
Keywords: Partial hepatectomy, liver regeneration, hepato-lymphatic axis, expression of class II MHC antigens in the liver, in vivo depletion of CD4, CD8+ lymphocytes, morphogenetic properties of lymphocytes.
- Type of paper
: Ph.D.
Title:
Faculty: Farmaceutsko-biokemijski fakultet u Zagrebu
Author: VERBANAC DONATELLA
Date of defense: 06/17/93
Language: engleski
Number of pages: 81
Summary: In this study, the biological activities of the proforms
ofbactenecins, which do not exhibit antimicrobial effects have
beeninvestigated with polypeptides purified by ion-exchange andpreparative
reverse phase liquid chromatography. It was chownthat proBa7 is a
monocyte-selective chemoattractant. The matureforms and proBay5 did not
show this activity. In vitro, theprobactenecins did not affect the blastic
transformation oflymphocytes. Enzimatic analysis has shown that
proBac5efficiently inhibits the activity of cathepsin L.
Keywords: Bioactivities of probactenecins, proBac5, proBac7, monocyte-selective chemoattractant, blastic transformation of lymphocytes, inhibition of cathepsin L.
- Type of paper
: Ph.D.
Title:
Faculty: Medicinski Fakultet u Rijeci
Author: BARAC-LATAS VESNA
Date of defense: 12/01/95
Language: hrvatski
Number of pages: 83
- Type of paper
: M.A.
Title: Immunomodulatory effects of somatostatin
Faculty: Medicinski Fakultet u Rijeci
Author: TROBONJAČA ZLATKO
Date of defense: 07/22/93
Language: hrvatski
Number of pages: 98
Summary: The effects of somatostatin (SMS 201-995) were
investigated1) in vivo: on humoral and cellular immunity and morphostasis
oflymphatic system and 2) in vitro: on blastic transformation oflymphocytes
stimulated by activators of different trasductionpathways and on phenotypic
profile of cultured cells. The datahave shown that SMS has a marked
immunosuppressive activity. Itsantimitotic effects on blastic
transformation of humanlymphocytes, stimulated by anti-CD3 monoclonal
antibodies andPMA, however, did not affect the expression of early
activationmarkers (IL-2R), nor some tyrozin protein kinase-relatedevents
(down regulation of CD4 molecule), indicating that itsintracellular action
goes through the others pathways.
Keywords: Somatostatin, SMS 201-995, cellular and humoral immunity, blastic transformation of lymphocytes, stimulation with anti CD3 monoclonal antibodies and PMA, down regulation of CD4 molecule.
- Type of paper
: M.A.
Title: Modulation of chronic relapsing experimental allergic
encephalomyelitis by somatostatin
Faculty: Medicinski Fakultet u Rijeci
Author: MUHVIĆ DAMIR
Date of defense: 07/16/91
Language: engleski
Number of pages: 97
Summary: The effects of somatostatin (SMS 201-995) were analysed in
rats,which are susceptible (DA strain) or resistant (AO strain) to
theinducement of cronic relapsisng form of experimental
allergicencephalomyelitis (EAE). The data have shown that SMS maymarkedly
affect the dinamycs of clinical course of disease inboth strains. The
effects were dependent on dose and oftreatment, indicating that SMS may
interfer with processes
Keywords: Chronic relapsisng experimental allergic encephalomyelitis, somatostatin, SMS 201-995, susceptible (DA) and resistant (AO) strain of rats.
- Type of paper
: M.A.
Title: Protective effects of peptidoglycans and indomethacin in
immunosuppressed mice
Faculty: Medicinski Fakultet u Rijeci
Author: MRAKOVČIĆ INES
Date of defense: 07/17/92
Language: hrvatski
Number of pages: 78
Summary: In mice immunosuppressed by halothane anaesthesia and
operativestress the effects of peptidoglycan monomer, its analogues
andindomethacin were investigated. The data have shown that PGM,
andespecially its N-acil and methal complexes may correct thehumoral type
of immunity in these mice. The effect was followedby hyperplasia of bone
marrow and an increase of hepaticproteins. Similar immunocorrection was
obtained byindomethacin.
Keywords: Immunosuppression by halothane anaesthesia and operative stress, peptidoglycan monomer, indomethacin, humoral immunity.
- Type of paper
: M.A.
Title: Experimental and clinical investigation of demyelinating
diseases in pregnancy
Faculty: Medicinski Fakultet u Rijeci
Author: BARAC-LATAS VESNA
Date of defense: 05/24/91
Language: hrvatski
Number of pages: 115
Summary: In this study were investigated the effects of pregnancy
onimmune status and clinical course of multiple sclerosis in womenand on
dinamics of experimental allergic encephalomyelitis in DArats, which were
sensitized with encephalitogen in differentphase of pregnancy. The data
have shown that the phase ofpregnancy may differently affect the immune
reactivity andoutcome of disease.
Keywords: Pregnancy, multiple sclerosis, experimental allergic encephalomyelitis, immune status.
- Type of paper
: M.A.
Title:
Faculty: Medicinski Fakultet u Rijeci
Author: RAVLIĆ-GULAN JAGODA
Date of defense: 03/01/95
Language: hrvatski
Number of pages: 123
Summary: We previously observed that PGM, linked with zinc (PGM-Zn,
"Pliva"-Zagreb) possesses the immunocorrective effects in some
experimentaly induced or naturaly occuring immunodeficient states.To obtain
information about the mechanism of the action of PGM-Zn, in this work we
examined the effects of PGM-Zn in SRBC sensitized mice, which were in vivo
depleted of CD4+ and/or CD8+ cells (by analysis of PFC generation, titar of
antigen specific and unspecific antibodies, class II expression in the
liver, phagocytic activity of peritoneal macrophages). The results revealed
that PGM-Zn, in spite of absence of CD4+ or CD8+ lymphocytes, can stimulate
the humoral immunity. After single depletion PFC production was enhanced in
both primary and secondary response. In the case of double depletion only
secondary response was increased. The reaction was followed by remarcable
increase of antigen specific and nonspecific IgM titer in sera in primary
reaction, and IgG and IgG1 titer in secondary reaction, and great
expression of class II antigens in the liver. PGM-Zn stimulated also the
phagocytic activity of peritoneal macrophages, which in coculture with
syngeneic splenocytes, stimulated with ConA showed suppressive activities.
Additional data, obtained in vitro, showed that PGM-Zn has the ability to
delay the early process of internalization of CD4 molecule in human
lymphocytes, stimulated by anti CD3+PMA, and accelerate the appearance of
IL-2R molecules on the surface of spontaneously growing cells.
Keywords: peptidoglycan monomer (PGM), zinc, PGM-Zn, immunostimulation, humoral immunity, hepatic class II expression, suppressive macrophages.
- Type of paper
: Mentorship
Title: Modulation of chronic relapsing experimental allergic
encephalomyelitis by somatostatin
Faculty: Medicinski Fakultet u Rijeci
Mentor: RADOŠEVIĆ-STAŠIĆ BISERKA
Date of defense: 07/16/93
Number of pages: 97
Author: Muhvić Damir
Degree level: M.A.
- Type of paper
: Mentorship
Title: Regeneration of hepatic and lymphoid tissue after the
depletion of lymphocyte subpopulations.
Faculty: Medicinski Fakultet u Rijeci
Mentor: ADLER NEVENKA
Date of defense: 12/27/93
Number of pages: 111
Author: Petković Marija
Degree level: Ph.D.
- Type of paper
: Mentorship
Title: Immunomodulating effects of somatostatin
Faculty: Medicinski Fakultet u Rijeci
Mentor: RADOŠEVIĆ-STAŠIĆ BISERKA
Date of defense: 07/22/93
Number of pages: 98
Author: Trobonjača Zlatko
Degree level: M.A.
- Type of paper
: Mentorship
Title: Protective effects of peptidoglycan and indomethacin in
immunosuppressed mice
Faculty: Medicinski Fakultet u Rijeci
Mentor: RADOŠEVIĆ-STAŠIĆ BISERKA
Date of defense: 07/17/92
Number of pages: 78
Author: Mrakovčić-Šutić Ines
Degree level: M.A.
- Type of paper
: Mentorship
Title: Experimental and clinical investigation of demyelinating
diseases in pregnancy
Faculty: Medicinski Fakultet u Rijeci
Mentor: RUKAVINA DANIEL
Date of defense: 05/24/91
Number of pages: 115
Author: Barac-Latas Vesna
Degree level: M.A.
- Type of paper
: Mentorship
Title:
Faculty: Medicinski Fakultet u Rijeci
Mentor: RADOŠEVIĆ-STAŠIĆ BISERKA
Date of defense: 03/01/95
Number of pages: 123
Author: Ravlić-Gulan Jagoda
Degree level: M.A.
- Type of paper
: Mentorship
Title:
Faculty: Medicinski Fakultet u Rijeci
Mentor: RUKAVINA DANIEL
Date of defense: 12/01/95
Number of pages: 83
Author: Barac-Latas Vesna
Degree level: Ph.D.
- Type of paper
: Survey/Study
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Rukavina, Daniel (41705)
Ordering party: "Pliva"
Institution depot: "Pliva"
Year: 1993
Number of pages: 10
Language: hrvatski
- Type of paper
: Survey/Study
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Rukavina, Daniel (41705)
Ordering party: "Pliva"
Institution depot: "Pliva"
Number of pages: 15
Language: hrvatski
- Type of paper
: Survey/Study
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Rukavina, Daniel (41705)
Ordering party: "Pliva"
Institution depot: "Pliva"
Year: 1991
Number of pages: 8
Language: hrvatski
- Type of paper
: Manuscript
Title:
- Authors:
- Radošević-Stašić, Biserka (39764)
- Trobonjača, Zlatko (173625)
- Ravlić-Gulan, Jagoda (194632)
- Rukavina, Daniel (41705)
Language: engleski
Summary: The effects of peptidoglycan mononer linked with Zn
(PGM-Zn) wereinvestigated in old mice, in which the immunodeficiency is
oftencombined with Zn deficiency. The data have shown that PGM-Zn is
apotent stimulator of humoral and cellular type of immunity and aninductor
of macrophages with suppressive characteristics.
Keywords: Peptidoglycan-monomer linked with zinc (PGM-Zn), immunosenescence, stimulation of humoral and cellular immunity, induction of macrophages with suppressive activity.