SVIBOR - Project code: 3-01-168

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Project code: 3-01-168


INTERACTIONS BETWEEN NEUROENDOCRINE AND LYMPHATIC SYSTEM


Main researcher: RADOŠEVIĆ-STAŠIĆ, BISERKA (39764)


Assistants
Type of research: basic
Duration from: 01/01/91. to 12/31/95.
Papers on project (total): 60
Papers on project quoted in Current Contents: 11
Institution name: Medicinski fakultet, Rijeka (62)
Department/Institute: Department for Physiology and Immunology
Address: Braće Branchetta 22
City: 51000 - Rijeka, Croatia
Communication
Phone: 385 (0)51-513-222
Fax: 385 (0)51-4915
Summary: The aim of this project was to proof the existence of interrelationship between the neuroendocrine and lymphatic system and their role in the control of intercellular communications. For this purpose the immunomodulatory effects of somatostatin, growth hormone, melatonin, probactenecins and peptidoglycan-monomer were investigated on basic immunological processes in vivo and in vitro and on some experimental models with the known participation of neuro-endocrine axis in their pathogenesis (EAE, streptozotocin-induced diabetes mellitus, halothane and operative stress-induced immunosupression). To obtain the information about general regulatory potential of lymphatic system, in additional experiments, the role of lymphatic cells in liver regeneration was studied, as well as the metabolic aspects of immune reaction. The data have shown that tested hormones and peptidergic substances may significantly modulate normal and pathological type of immune reaction. Somatostatin gave mostly the immunosuppresive effects. Neutrophilic probactenecins attracted the monocytes and inhibited the proteolytic activity of cathepsin L, while PGM and its analogues had potent immunocorrective and hepatocorrective potential. The results, obtained in the hepatectomized animals have shown that lymphatic cells are not involved only in immunological processes, but also in the control of normal growth.

Keywords: Neuroimmumodulation, somatostatin, SMS 201-995, growth hormone, melatonin, probactenecins, peptidoglycan-monomer, autoimmunity, experimental allergic encephalomyelitis, streptozotocin-induced diabetes mellitus, halothan and operative stress-induced immunosuppression, regeneration of the liver, morphogenetic functions of T lymphocytes, autoantibodies, metabolits in immune reaction.

Research goals: The main aims of the research were to proof the existence of interrelationship between the neuro-endocrine and lymphatic system and to determine their fuctions in the maintenance of homeostasis. For this purpose the following was done: 1) the testing of the effects of some peptidergic hormons (somatostatin and growth hormone) and substances, isolated from neutrophils (probactenecins) and bacterial cell walls (peptidoglycan monomer) on basic immunological processes in vivo and in vitro, 2) the testing of the efficiency of these substances to correct some autoimmune diseases and immunodeficient states, 3) the analysis of morphogenetic functions of lymphatic system and 4) the investigation of metabolic aspects of immune reaction. It was expected that the results would provide new insight into the biological basis of the bidirectional communication between the neuro-endocrine and immune system and give new explanation for the pathogenesis and therapy of certain autoimmune diseases and states of immunodeficiencies. Additionally, it was belived that the data of experiments testing the role of lymphatic cells in the processes of tissue regeneration, might help to discriminate between the pathological and physiological functions of the immune system.

COOPERATION - PROJECTS


  1. Name of project: 3-01-254 Peptidoglikan monomer i derivati
    Name of institution: Znanstvena jedinica za patobiokemijska i klinička istraživanja, KBC Rebro
    City: 10000 - Zagreb, Croatia

COOPERATION - INSTITUTIONS


  1. Name of institution: Karolinska hospital
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Stockholm, Švedska

  2. Name of institution: Center for Experimental Pathology
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 6604 - Locarno, Švicarska

  3. Name of institution: Hrvatski institut za istraživanje mozga
    Type of institution: University/Faculty
    Type of cooperation: Joint project
    City: 10000 - Zagreb, Croatia

  4. Name of institution: "Pliva"
    Type of institution: State institute
    Type of cooperation: Joint project
    City: 10000 - Zagreb, Croatia

  5. Name of institution: Institute of Virology
    Type of institution: State institute
    Type of cooperation: Joint publishing of scientific papers
    City: D-97078 - Wurzburg, Germany

  6. Name of institution: Neurological Institute
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Beč, Austria
Other information about the project.
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