SVIBOR - Project code: 3-01-192

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-192

EARLY DETECTION OF FETAL HYPOXIA USING CORDOCENTESIS, COLOR DOPPLER AND COMPUTERISED CTG

Main researcher: RAJHVAJN, BRANKO (21953)

Assistants

RUŠINOVIĆ, FRANE (113514)
RELJA, ZORAN (149261)
BUJANOVIĆ, VLADIMIR (37025)
MIRIĆ, DANKA (900522)

Type of research: applied
Duration from: 01/01/91.

Papers on project (total): 15
Papers on project quoted in Current Contents: 3

Institution name: Bolnica "Sveti duh", Zagreb (129)
Department/Institute: Department of obstetrics and gynecology Ultrasonic institute University of Zagreb
Address: Sveti Duh 64
City: 10000 - Zagreb, Croatia

Communication: Phone: 385 (0)1 579 251; Fax: 385 (0)1 579 248

Summary: Early detection of the fetal hypoxia declines perinatal mortality and morbidity. Using a new diagnostic methods it is possible to distinguish a high risk pregnant women from those with pathologic pregnancy who has to be hospitalised. Measuring the fetal blood flow in uteroplacental and fetal circulation and analysing the redistribution of the fetal hemodinamics it is possible to valuate fetal viability. Using acid-base profile and the hormonal status in fetal blood it is possible to detect intrauterine pathologic changes. With the computerised CTG is possible to analyse the fetal oxygenation while feuses using the compensatory mechanisms try to redistribute the circulation.

Keywords: Fetal hypoxia, high risk pegnancy, cordocentesis, blood flow velocity waveform analysis, computerised CTG

Research goals: The aim of this study is to test several diagnostic procedures that are used in detection of a fetal growth retardation. Some criteria are made in order to distinguish high risk pregnancies from the pathologic pregnancies. It is of interest to calculate the best timing to finish the pregnancies in a group of patients with high risk pregnancy, and also to treat the mothers with oxygen therapy in a group of patients carring a fetus with severe growth ratardation. By providing maternal hyperoxia it coud be expect that fetal arterial pO2 increases due to additional amount of oxygen resulting in increased aerobic matabolism. Also mothers resting should improve the placental perfusion as well and its metabolic possibilities. The therapy success could be evaluate by performing fetal and uteroplacental (color Doppler) blood flow analysis and computerised CTG as well as analysing the concentration of the pO2, pCO2, pH in fetal blood sample. Pathologic changes in fetal and uteroplacental circulation (high resistance to blood flow - RI, high pulsatility index - PI, high velocity - Vmax) after oxygen therapy showed normalised values, or if not totaly normal then its declining tendency, and no more "brain-sparing" efect. The neonatal viability and APGAR, concentration of the pO2, pCO2 and hemoglobin and pH showed improved values in comparison to the neonates without oxygen therapy during pregnancy.

Other information about the project.


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Last update: 10/24/95
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