SVIBOR - Project code: 3-01-199

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR - Collecting Data on Projects in Croatia

Project code: 3-01-199

Impact of the presence of P-fimbriae in E.coli on urinary tract infections therapy

Main researcher: TAMBIĆ, TERA (41176)

Assistants

MILUTINOVIĆ, SLOBODAN (44001)
TAMBIĆ, ARJANA (172380)

Type of research: applied
Duration from: 01/01/91.

Papers on project (total): 7
Papers on project quoted in Current Contents: 1

Institution name: Bolnica "Sveti duh", Zagreb (129)
Department/Institute: Department of clinical microbiology "Sv. Duh" General Hospital
Address: Sv. Duh 64
City: 10000 - Zagreb, Croatia

Communication

Summary: Bacterial adherence is an important virulence factor. In this study we have investigated whether E.coli testing for P-fimbriae is important in determining the duration of the therapy and choice of antibiotic in patients with urinary tract infection. We chose at random 121 patients with uncomplicated urinary tract infection for three day treatment, and 154 patients with the same diagnosis we treated for seven days. We devided patients at random into groups treated with pefloxacin (PF) - 44 patients / 3 days, 51 patients / 7 days, cefuroxime-axetil (CXM) - 41 patients / 3 days, 54 patients / 7 days, and amoxicillin with clavulanic acid 36 patients / 3 days, 48 patients / 7 days. Three day therapy proved to be successful in eradicating non-fimbriated E.coli, when treated with PF or AMC. CXM failed to eradicate five out of 31 non-fimbriated strains. Seven day therapy with all of the tested antibiotics eradicated non-fimbriated strains, whereas in case of the P-fimbriated E.coli PF failed to eradicate four out of 11 strains, CXM 4 out of 12 strains, and AMC six out of 14 strains. These results indicate that the P-fimbriation test is very important in planning the duration of therapy, but it does not influence the choice of antibiotic significantly.

Keywords: Urinary tract infection, E.coli, P-fimbriae, bacterial adherence, duration of therapy, choice of antibiotic

Research goals: The aim of this study was to estimate the importance of the simple diagnostic procedure, such as P-fimbriation test for E.coli in determining the choice of the antibiotic and the duration of the therapy. This simple test could improve the efficacy and the rationalization of the antibiotic therapy. In this project we wanted to determine whether the findings of this test could predict the duration of therapy and the choice of antibiotic in the treatment of urinary tract infections. It is known that some antibiotics (i.e. beta-lactams) reduce the quantity of P-fimbriae, so we expected that these antibiotics will perhaps prove to be clinically more effective as well.

COOPERATION - PROJECTS

Name of project: 3-01-203 Patofiziologija i terapija uremije
Name of institution: Znanstvena jedinica bolnice Sveti Duh
City: 10000 - Zagreb, Croatia

Other information about the project.


Ministry of Science and Technology	Croatian language	Svibor homepage	Alphabetic list	Sorted on project code	Sorted on institutions	Search	Help

Last update: 10/16/95
Information: svibor@znanost.hr