SVIBOR - Project code: 3-01-199


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Project code: 3-01-199

Impact of the presence of P-fimbriae in E.coli on urinary tract infections therapy

Main researcher: TAMBIĆ, TERA (41176)

Type of research: applied
Duration from: 01/01/91.

Papers on project (total): 7
Papers on project quoted in Current Contents: 1
Institution name: Bolnica "Sveti duh", Zagreb (129)
Department/Institute: Department of clinical microbiology "Sv. Duh" General Hospital
Address: Sv. Duh 64
City: 10000 - Zagreb, Croatia

Summary: Bacterial adherence is an important virulence factor. In this study we have investigated whether E.coli testing for P-fimbriae is important in determining the duration of the therapy and choice of antibiotic in patients with urinary tract infection. We chose at random 121 patients with uncomplicated urinary tract infection for three day treatment, and 154 patients with the same diagnosis we treated for seven days. We devided patients at random into groups treated with pefloxacin (PF) - 44 patients / 3 days, 51 patients / 7 days, cefuroxime-axetil (CXM) - 41 patients / 3 days, 54 patients / 7 days, and amoxicillin with clavulanic acid 36 patients / 3 days, 48 patients / 7 days. Three day therapy proved to be successful in eradicating non-fimbriated E.coli, when treated with PF or AMC. CXM failed to eradicate five out of 31 non-fimbriated strains. Seven day therapy with all of the tested antibiotics eradicated non-fimbriated strains, whereas in case of the P-fimbriated E.coli PF failed to eradicate four out of 11 strains, CXM 4 out of 12 strains, and AMC six out of 14 strains. These results indicate that the P-fimbriation test is very important in planning the duration of therapy, but it does not influence the choice of antibiotic significantly.

Keywords: Urinary tract infection, E.coli, P-fimbriae, bacterial adherence, duration of therapy, choice of antibiotic

Research goals: The aim of this study was to estimate the importance of the simple diagnostic procedure, such as P-fimbriation test for E.coli in determining the choice of the antibiotic and the duration of the therapy. This simple test could improve the efficacy and the rationalization of the antibiotic therapy. In this project we wanted to determine whether the findings of this test could predict the duration of therapy and the choice of antibiotic in the treatment of urinary tract infections. It is known that some antibiotics (i.e. beta-lactams) reduce the quantity of P-fimbriae, so we expected that these antibiotics will perhaps prove to be clinically more effective as well.


  1. Name of project: 3-01-203 Patofiziologija i terapija uremije
    Name of institution: Znanstvena jedinica bolnice Sveti Duh
    City: 10000 - Zagreb, Croatia

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Last update: 10/16/95